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ChemicalBook >> CAS DataBase List >>4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

CAS No.
16673-34-0
Chemical Name:
4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
Synonyms
5-Chloro-2-Methoxy-N-(4-sulfaMoylphenethyl)benzaMide;5-CHLORO-2-METHOXY-N-[2-(4-SULFAMOYLPHENYL)ETHYL]BENZAMIDE;NLRP3i;NLRP3-IN-2;Einecs 240-722-5;16673-34-0 NLRP3i;Glyburide USP RC A;Glibenclamide Impurity 7;Glibenclamide EP Impurity A;Glyburide Related CoMpound A
CBNumber:
CB7278059
Molecular Formula:
C16H17ClN2O4S
Molecular Weight:
368.84
MDL Number:
MFCD00193756
MOL File:
16673-34-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-12 09:14:19
Product description Number Pack Size Price
Glyburide Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material PHR2414 50MG $593
Glibenclamide impurity A European Pharmacopoeia (EP) Reference Standard G0325010 10 mg $172
4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonamide British Pharmacopoeia (BP) Reference Standard BP071 25MG $292
5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 95% 463442 5g $121
Glyburide Related Compound A United States Pharmacopeia (USP) Reference Standard 1295516 25mg $1390
More product size

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Properties

Melting point 209-214 °C
Density 1.356±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 45 mg/ml).
form Solid
pka 10.14±0.10(Predicted)
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI InChI=1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)
InChIKey KVWWTCSJLGHLRM-UHFFFAOYSA-N
SMILES C(NCCC1=CC=C(S(N)(=O)=O)C=C1)(=O)C1=CC(Cl)=CC=C1OC
CAS DataBase Reference 16673-34-0(CAS DataBase Reference)
FDA UNII 8TF6P2NUB5
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Hazard Codes  T
Risk Statements  23-24-25
Safety Statements  24/25
WGK Germany  1
HS Code  2935909550
Storage Class 11 - Combustible Solids
REACH Registrations Active

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2414 Glyburide Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material 16673-34-0 50MG $593 2026-04-30 Buy
Sigma-Aldrich G0325010 Glibenclamide impurity A European Pharmacopoeia (EP) Reference Standard 16673-34-0 10 mg $172 2026-04-30 Buy
Sigma-Aldrich BP071 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonamide British Pharmacopoeia (BP) Reference Standard 16673-34-0 25MG $292 2026-04-30 Buy
Sigma-Aldrich 463442 5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 95% 16673-34-0 5g $121 2026-04-30 Buy
Sigma-Aldrich 1295516 Glyburide Related Compound A United States Pharmacopeia (USP) Reference Standard 16673-34-0 25mg $1390 2026-04-30 Buy
Product number Packaging Price Buy
PHR2414 50MG $593 Buy
G0325010 10 mg $172 Buy
BP071 25MG $292 Buy
463442 5g $121 Buy
1295516 25mg $1390 Buy

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Chemical Properties,Uses,Production

Description

NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promisingin vivoprotective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2

Chemical Properties

Light Yellow Solid

Uses

An impurity arising in the synthesis of Glyburide (G598350).

General Description

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.

storage

Store at +4°C

References

[1] JACOB FULP. Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization[J]. Journal of Medicinal Chemistry, 2018, 61 12: 5412-5423. DOI:10.1021/acs.jmedchem.8b00733
[2] CARLO MARCHETTI. A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse.[J]. Journal of Cardiovascular Pharmacology, 2014, 63 4: 316-322. DOI:10.1097/fjc.0000000000000053

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Preparation Products And Raw materials

Global( 219)Suppliers
Supplier Tel Email Country ProdList Advantage
Xiamen Shindano Biotechnology Co.,ltd
0592-6266840 15750707980 sales@chemsdano.com China 291 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58

View Lastest Price from 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NLRP3-IN-2 pictures 2026-05-11 NLRP3-IN-2
16673-34-0
 $53.00-123.00 98.98% 10g TargetMol Chemicals Inc.
4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide pictures 2019-07-06 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
16673-34-0
 $1.00 1KG 95%-99% 1000kg Career Henan Chemical Co
  • NLRP3-IN-2 pictures
  • NLRP3-IN-2
    16673-34-0
  • $53.00-123.00
  • 98.98%
  • TargetMol Chemicals Inc.
4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Glyburide Related Compound A (25 mg) (5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide) 4-[2-(2-Methoxy-5-chlorobenzene-1-carboxaMido)ethyl]benzenesulfonaMide 5-Chloro-N-(p-sulfaMoylphenethyl)-o-anisaMide GlibenclaMide (Glyburide) IMpurity A Glyburide Related CoMpound A Glyburide Related Compound A (25 mg) (4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide) Glyburide USP RC A 5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 95% NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome InhibitorⅠ 5-chloro-2-methoxy-n-(2-(4-sulfamoyl-phenyl)ethyl N-(2-(4-(Aminosulfonyl)phenyl)ethyl)-5-chloro-2-methoxybenzamide 4-(5-CHLORO-2-METHOXYBENZAMIDOETHYL)BENZENESULFONAMIDE 4-[2-(5-CHLORO-2-METHOXY-BENZAMIDE)ETHYL]-BENZENESULPHONAMIDE 4-(2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL)PHENYLSULFONAMIDE 4-[2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL]PHENYLSULPHONAMIDE 4-[2-(2-METHOXY-5-CHLOROBENZAMIDO)ETHYL]BENZENESULFONAMIDE 5-CHLORO-2-METHOXY-N-[2-(P-SULFAMOYLPHENYL)ETHYL]BENZAMIDE N-(2-(4-sulfamoyl)phenyl)ethyl-5-chloro-2-methoxybenzamide N-[2-[4-(aminosulphonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide 4-[2-(2-Methoxy-5-Chloro Benzamido)Ethyl]Sulphonamide [2-(5-Chloro-2.methoxybenzamido)-ethyl]-phenylsulfonamide 4-Ethyl-3-(2-methoxy-5-chlorbenzamido)-benzolsulfonamid 4-2-(5-CHLORO-2-METHOXYBENZAMIDO)-ETHYL BENZENSULFONAMIDE BENZAMIDE, N-[2-[4-(AMINOSULFONYL) PHENYL]ETHYL]-5-CHLORO-2-METHOXY (GLYBIN SULFONAMIDE) Einecs 240-722-5 N-[4-(Aminosulfonyl)phenethyl]-2-methoxy-5-chlorobenzamide 5-Chloro-2- methoxy-N-[2-(4-sulphamoylphenyl Glibenclamide Impurity 1(Glibenclamide EP Impurity A) NLRP3i Glyburide USP Related Compound A Glibenclamide (Glyburide) EP Impurity A Glibenclamide ImpurityⅠ:5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 5-chloro-2-methoxy-N-[2-(4-sulphamoylphenyl)ethyl]benzamide Glibenclamide EP Impurity A 5-Chloro-2-methoxy-N-[2-(4-sulfamoy 16673-34-0 NLRP3i Benzamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxy- NLRP3-IN-2 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide ISO 9001：2015 REACH Glibenclamide EP Impurity A/ Glyburide Related Compound A Glibenclamide EP Impurity AQ: What is Glibenclamide EP Impurity A Q: What is the CAS Number of Glibenclamide EP Impurity A Q: What is the storage condition of Glibenclamide EP Impurity A Q: What are the applications of Glibenclamide EP Impurity A Glyburide Related Compound A (4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide) (1295516) Glibenclamide Impurity 7 Sulphonamide of Glibenclamide Glibenclamide (Glyburide) EP Impurity A (Glibenclamide (Glyburide) USP Related Compound A) 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide|||NLRP3 Inflammasome Inhibitor I Glibenclamide Impurity Ⅰ(4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide) 5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide Glibenclamide ImpurityⅠ:5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide Glibenclamide (Glyburide) EP Impurity A (Glyburide USP Related Compound A) 5-CHLORO-2-METHOXY-N-[2-(4-SULFAMOYLPHENYL)ETHYL]BENZAMIDE 5-Chloro-2-Methoxy-N-(4-sulfaMoylphenethyl)benzaMide 16673-34-0 C16H17ClN2O4S ClC6H3OCH3CONHCH2C6H4SO2NH2 C16H17N2O4ClS
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