Gramine
- CAS No.
- 87-52-5
- Chemical Name:
- Gramine
- Synonyms
- 1-(1H-indol-3-yl)-N,N-dimethylmethanamine;Gramin;DONAXINE;Donaxin;GRAMINE;Doranine;NSC 16892;GRAMINE(RG);Gramine >Gramine,>99%
- CBNumber:
- CB7342118
- Molecular Formula:
- C11H14N2
- Molecular Weight:
- 174.24
- MDL Number:
- MFCD00005629
- MOL File:
- 87-52-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Gramine 99% | G10806 | 25g | $148 |
| Gramine >98.0%(T) | D0653 | 25g | $31 |
| Gramine >98.0%(T) | D0653 | 250g | $151 |
| Gramine ≥98% | 23401 | 5mg | $36 |
| Gramine ≥98% | 23401 | 50mg | $236 |
| More product size | |||
| Melting point | 132-134 °C (lit.) |
|---|---|
| Boiling point | 295.23°C (rough estimate) |
| Density | 1.0715 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point | 167 °C |
| storage temp. | Refrigerator (+4°C) |
| solubility | almost transparency in Methanol |
| form | Powder |
| pka | 17.00±0.30(Predicted) |
| color | Beige |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Merck | 14,4533 |
| BRN | 140521 |
| InChI | 1S/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3 |
| InChIKey | OCDGBSUVYYVKQZ-UHFFFAOYSA-N |
| SMILES | CN(C)Cc1c[nH]c2ccccc12 |
| LogP | 2.177 (est) |
| CAS DataBase Reference | 87-52-5(CAS DataBase Reference) |
| FDA UNII | FGQ8A78L14 |
| NIST Chemistry Reference | 1H-Indole-3-methanamine, N,N-dimethyl-(87-52-5) |
| EPA Substance Registry System | 1H-Indole-3-methanamine, N,N-dimethyl- (87-52-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352+P312-P362+P364 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 45-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NL7525000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Oral |
|||||||||
| NFPA 704 |
|
Gramine price More Price(81)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G10806 | Gramine 99% | 87-52-5 | 25g | $148 | 2026-04-30 | Buy |
| TCI Chemical | D0653 | Gramine >98.0%(T) | 87-52-5 | 25g | $31 | 2026-04-30 | Buy |
| TCI Chemical | D0653 | Gramine >98.0%(T) | 87-52-5 | 250g | $151 | 2026-04-30 | Buy |
| Cayman Chemical | 23401 | Gramine ≥98% | 87-52-5 | 5mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 23401 | Gramine ≥98% | 87-52-5 | 50mg | $236 | 2026-04-30 | Buy |
Gramine Chemical Properties,Uses,Production
Chemical Properties
3-(Dimethylaminomethyl)indole [87-52-5], gramine, C11H14N2, Mr 174.25, mp 138 – 139 ℃, forms colorless needles. The compound is soluble in ethanol, diethyl ether, and chloroform and insoluble in water. It can be synthesized from indole by the Mannich reaction with dimethyl-amine and formaldehyde. Gramine is used to synthesize D,L-tryptophan, the plant growth regulators indole-3-acetic acid and indole-3-butanoic acid as well as the intermediate tryptamine.
Uses
Reactant for preparation of:
- Dopamine D2 receptor antagonists
- Anti-malarial drugs
- 5-indolyl-Mannich bases
- Proliferation inhibitors
- Inhibitors of human mast cell chymase
- Preparation of DL-tryptophan
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- 3-vinylindoles
- Serotonin 5-HT6 receptor ligand templates
- Selective protein kinase c delta (PKCδ) down regulators
Definition
ChEBI: Gramine is an aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3. It has a role as a plant metabolite, a serotonergic antagonist, an antiviral agent and an antibacterial agent. It is an aminoalkylindole, an indole alkaloid and a tertiary amino compound. It is a conjugate base of a gramine(1+).
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
storage
Room temperature
Purification Methods
Crystallise gramine from diethyl ether, ethanol or acetone. It sublimes at 59o/0.001mm. The hydrochloride crystallises from EtOH/Et2O with m 190.5-191.0o(dec). [Culvenor et al. Aust J Chem 17 1301 1964, Beilstein 22 III/IV 4302, 22/10 V 25.]
Gramine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 4616 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
View Lastest Price from Gramine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Gramine
87-52-5
|
$55.00-79.00 | 99.95% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-09 | Gramine
87-52-5
|
$1.00-122.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2023-02-24 | Gramine
87-52-5
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
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