KT5823
- CAS No.
- 126643-37-6
- Chemical Name:
- KT5823
- Synonyms
- KT5823;KT 5283;KT5823;KT-5823;KT5823, inhibitor of PKG;PROTEIN KINASE INHIBITOR KT 5823;KT5823 - CAS 126643-37-6 - Calbiochem;9-Methoxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epxoy-1H,8H,11H-2,7B-11A-triazadibenzo(A,G)cycloocta(cde)-trinden-1-one;(9R)-2,3,9,10,11,12-Hexahydro-10β-methoxy-2,9-dimethyl-1-oxo-9α,12α-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester;(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester;(9S, 10R, 12R)-2,3,9,10,11,12-HEXAHYDRO-10-METHOXY-2,9-DIMETHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID, METHYL ESTER
- CBNumber:
- CB7377637
- Molecular Formula:
- C29H25N3O5
- Molecular Weight:
- 495.53
- MDL Number:
- MFCD09878278
- MOL File:
- 126643-37-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| KT5823 - CAS 126643-37-6 - Calbiochem Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). | 420321 | 50μg | $175 |
| KT 5823 ≥85% (HPLC), lyophilized powder | K1388 | 100μg | $241 |
| KT5823 - CAS 126643-37-6 - Calbiochem Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). | 420321 | 100μg | $285 |
| KT 5823 ≥95% | 10010965 | 25μg | $41 |
| KT 5823 ≥95% | 10010965 | 50μg | $75 |
| Boiling point | 629.2±55.0 °C(Predicted) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ethyl acetate: 5 mg/mL |
| form | lyophilized powder |
| pka | -1.01±0.60(Predicted) |
| color | white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. |
| InChIKey | XCMSIGRHKNQVBF-UDUFFBJHNA-N |
| SMILES | N12C3=C(C4=C1C1=C(C5=C(N1[C@]1([H])O[C@@]2(C)[C@](C)(C(OOC)=O)C1)C=CC=C5)C1C(=O)N(C)CC=14)C=CC=C3 |&1:10,13,15,r| |
| FDA UNII | WY40BAB02W |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280-P271 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xi |
| WGK Germany | 3 |
| F | 10 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
KT5823 price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 420321 | KT5823 - CAS 126643-37-6 - Calbiochem Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). | 126643-37-6 | 50μg | $175 | 2026-04-30 | Buy |
| Sigma-Aldrich | K1388 | KT 5823 ≥85% (HPLC), lyophilized powder | 126643-37-6 | 100μg | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | 420321 | KT5823 - CAS 126643-37-6 - Calbiochem Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). | 126643-37-6 | 100μg | $285 | 2026-04-30 | Buy |
| Cayman Chemical | 10010965 | KT 5823 ≥95% | 126643-37-6 | 25μg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 10010965 | KT 5823 ≥95% | 126643-37-6 | 50μg | $75 | 2026-04-30 | Buy |
KT5823 Chemical Properties,Uses,Production
Description
KT5823 (126643-37-6) is a selective protein kinase G inhibitor (K>i =0.23, 4 and >10 μM for PKG, PKC and PKA respectively.1Arrests human skin fibroblast cell cycle after the G0/G1 boundary.2 KT5823 abolishes the cGMP-induced relaxation in smooth muscle cells (IC50=60 nM).3Cell permeable.
Chemical Properties
Yellow powder
Uses
KT 5823 is a protein kinase inhibitor shown to increase TSH-induced NIS expression, and thus iodide uptake, in thyroid cells.
Uses
KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons and in mouse brain capillary endothelial cells.
Definition
ChEBI: KT 5823 is an organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of methyl (3R)-3-methoxy-2-methyltetrahydrofuran-3-carboxylate (the 2S,3R,5R product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1-methyl-1,5-dihydro-2H-pyrrol-2-one. It has a role as an EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor. It is a gamma-lactam, an organic heterooctacyclic compound, a methyl ester, a hemiaminal and an indolocarbazole.
General Description
Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). Inhibits protein kinase C (Ki = 4.0 μM) and protein kinase A (Ki >10.0 μM) at higher concentrations.
Biological Activity
Selective inhibitor of protein kinase G (K i values are 0.23, 4 and > 10 μ M for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC 50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μ M. Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C (desiccate)
References
[1] HIROSHI KASE. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases[J]. Biochemical and biophysical research communications, 1987, 142 2: Pages 436-440. DOI:10.1016/0006-291x(87)90293-2
[2] D M GADBOIS. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1992, 89 18: 8626-8630. DOI:10.1073/pnas.89.18.8626
[3] K S MURTHY G M M. Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells.[J]. American Journal of Physiology, 1995, 268 1 Pt 1: C171-80. DOI:10.1152/ajpcell.1995.268.1.c171
KT5823 Preparation Products And Raw materials
KT5823 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 12272 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11438 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7237 | 62 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29975 | 65 |
