ACETYLSALICYLIC ANHYDRIDE
- CAS No.
- 1466-82-6
- Chemical Name:
- ACETYLSALICYLIC ANHYDRIDE
- Synonyms
- 2-(Acetyloxy)benzoic anhydride;Aspirin IMpurity F;Vigal;pircan;contraflu;NSC 63848;NSC 80056;aspirinanhydride;Aspirin Impurity 6;Aspirin EP Impurity F
- CBNumber:
- CB7439577
- Molecular Formula:
- C18H14O7
- Molecular Weight:
- 342.3
- MDL Number:
- MFCD00013236
- MOL File:
- 1466-82-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Acetylsalicylic Anhydride (Aspirin Impurity F) PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial | PHR1942 | 50mg | $793 |
| Acetylsalicylic Anhydride >95%(HPLC) | TRC-A187785-25MG | 25mg | $200 |
| Acetylsalicylic Anhydride >95%(HPLC) | TRC-A187785-250MG | 250mg | $289 |
| Acetylsalicylic Anhydride >95%(HPLC) | TRC-A187785-10MG | 10mg | $124 |
| Aspirin Impurity F | BAA46682 | 5g | $580 |
| More product size | |||
| Melting point | 80-83 °C |
|---|---|
| Boiling point | 511.2±35.0 °C(Predicted) |
| Density | 1.306±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | White to Off-White |
| BRN | 2015320 |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C18H14O7/c1-11(19)23-15-9-5-3-7-13(15)17(21)25-18(22)14-8-4-6-10-16(14)24-12(2)20/h3-10H,1-2H3 |
| InChIKey | OAWXYINGQXLWOE-UHFFFAOYSA-N |
| SMILES | C(=O)(OC(=O)C1C=CC=CC=1OC(C)=O)C1C=CC=CC=1OC(C)=O |
| FDA UNII | XIA5Z82RHB |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 3 |
| RTECS | VO0710000 |
| F | 10-21 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 |
ACETYLSALICYLIC ANHYDRIDE price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1942 | Acetylsalicylic Anhydride (Aspirin Impurity F) PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial | 1466-82-6 | 50mg | $793 | 2026-04-30 | Buy |
| TRC | TRC-A187785-25MG | Acetylsalicylic Anhydride >95%(HPLC) | 1466-82-6 | 25mg | $200 | 2026-06-03 | Buy |
| TRC | TRC-A187785-250MG | Acetylsalicylic Anhydride >95%(HPLC) | 1466-82-6 | 250mg | $289 | 2026-06-03 | Buy |
| TRC | TRC-A187785-10MG | Acetylsalicylic Anhydride >95%(HPLC) | 1466-82-6 | 10mg | $124 | 2026-06-03 | Buy |
| Biosynth | BAA46682 | Aspirin Impurity F | 1466-82-6 | 5g | $580 | 2026-06-04 | Buy |
ACETYLSALICYLIC ANHYDRIDE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Acetylsalicylic Acid Impurity D
Uses
Acetylsalicylic Acid (A187780) Impurity D.
Synthesis
50-78-2
1466-82-6
General procedure for the synthesis of 2-(acetyloxy)benzoic anhydride from acetylsalicylic acid: 1. prepare a suspension of 2-acetoxybenzoic acid (5.0 g, 28 mmol) in 30 mL of dichloromethane. 2. a solution of N,N'-dicyclohexylcarbodiimide (DCC, 2.9 g, 13.9 mmol) in 10 mL of dichloromethane was added to the above suspension. 3. The reaction mixture was stirred at room temperature overnight. 4. After completion of the reaction, the by-product dicyclohexylurea (DCU) was filtered through a glass filter and washed with a small amount of dichloromethane. 5. The solvent was evaporated and the resulting residue was dissolved in ethyl acetate. 6. The resulting suspension was filtered through a glass filter to remove residual DCU. 7. The filtrate was evaporated to give 2-(acetyloxy)benzoic anhydride as a clear thick oil, which solidified after storage at -20 °C. Yield: 4.6 g (quantitative). 1H NMR (CDCl3, 400 MHz): δ 8.08 (d, 2H, J = 7.9 Hz), 7.70 (t, 2H, J = 7.8 Hz), 7.40 (t, 2H, J = 7.7 Hz), 7.19 (d, 2H, J = 8.1 Hz), 2.31 (s, 6H). 13C NMR (CDCl3, 100 MHz): δ 169.42, 159.29, 151.83, 135.54, 132.24, 126.29, 124.42, 121.69, 20.89. IR (KBr) νmax (cm-1): 3570 (w), 3491 (w), 3445 (w), 3332 (br), 3205 (w), 3100 (s, CH), 2932 (s, CH), 2855 (w), 2409 (w), 2032 (w), 1789 (br, C=O), 1728 (br, C=O) , 1603 (s, C=C), 1581 (s), 1484 (s), 1451 (s), 1369 (s), 916 (s), 506 (s). HRMS m/z Calcd. for C18H14Na7O6: (M + Na)+ 365.0637. Found: 365.0638. Melting point: 80-85°C.
References
[1] Patent: WO2015/89389, 2015, A1. Location in patent: Paragraph 0098
[2] Tetrahedron Letters, 2016, vol. 57, # 3, p. 325 - 328
[3] Synthetic Communications, 2001, vol. 31, # 3, p. 395 - 399
[4] Chemische Berichte, 1910, vol. 43, p. 2990
[5] Chem. Zentralbl., 1911, vol. 82, # I, p. 1568
ACETYLSALICYLIC ANHYDRIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3992 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15082 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
View Lastest Price from ACETYLSALICYLIC ANHYDRIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | ACETYLSALICYLIC ANHYDRIDE
1466-82-6
|
$4656.00 | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- ACETYLSALICYLIC ANHYDRIDE
1466-82-6
- $4656.00
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
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