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ChemicalBook >> CAS DataBase List >>2-Chloro-4-picoline

2-Chloro-4-picoline

CAS No.
3678-62-4
Chemical Name:
2-Chloro-4-picoline
Synonyms
2-CHLORO-4-METHYLPYRIDINE;2-CHLOROPICOLINE;2-CHLORO-4-PICOLINE;2-Chloro-4-Pilcoline;4-Picoline, 2-chloro-;2-Chloro-4-picoline,98%;2-CHLORO-GAMMA-PICOLINE;2-Chlor-4-methylpyridin;2-chloro-4-methylpyrdine;2-Chloro-4-mehyl pyridine
CBNumber:
CB7481718
Molecular Formula:
C6H6ClN
Molecular Weight:
127.57
MDL Number:
MFCD00023418
MOL File:
3678-62-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:43:57
Product description Number Pack Size Price
2-Chloro-4-methylpyridine 98% 116327 5ml $122
2-Chloro-4-methylpyridine 98% 116327 25ml $290
2-Chloro-4-methylpyridine >98.0%(GC) C1992 5g $23
2-Chloro-4-methylpyridine >98.0%(GC) C1992 25g $64
2-Chloro-4-methylpyridine Asreported 269564 50g $333
More product size

2-Chloro-4-picoline Properties

Melting point 115°C
Boiling point 194-195 °C (lit.)
Density 1.142 g/mL at 25 °C (lit.)
refractive index n20/D 1.529(lit.)
Flash point 193 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Liquid
pka 0.94±0.10(Predicted)
Specific Gravity 1.14
color Clear colorless to light yellow
InChI InChI=1S/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
InChIKey MZVSTDHRRYQFGI-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC(C)=C1
CAS DataBase Reference 3678-62-4(CAS DataBase Reference)
NIST Chemistry Reference 2-Cl-4-(CH3)-pyridine(3678-62-4)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36-36/37/39
WGK Germany  3
HazardClass  IRRITANT, IRRITANT-HARMFUL
HS Code  29349990
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Chloro-4-picoline price More Price(87)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 116327 2-Chloro-4-methylpyridine 98% 3678-62-4 5ml $122 2026-04-30 Buy
Sigma-Aldrich 116327 2-Chloro-4-methylpyridine 98% 3678-62-4 25ml $290 2026-04-30 Buy
TCI Chemical C1992 2-Chloro-4-methylpyridine >98.0%(GC) 3678-62-4 5g $23 2026-04-30 Buy
TCI Chemical C1992 2-Chloro-4-methylpyridine >98.0%(GC) 3678-62-4 25g $64 2026-04-30 Buy
Usbiological 269564 2-Chloro-4-methylpyridine Asreported 3678-62-4 50g $333 2026-06-03 Buy
Product number Packaging Price Buy
116327 5ml $122 Buy
116327 25ml $290 Buy
C1992 5g $23 Buy
C1992 25g $64 Buy
269564 50g $333 Buy

2-Chloro-4-picoline Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liquid.

Uses

2-Chloro-4-methylpyridine is used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines as potential antipsychotics. It is also used in the preparation of trifluoromethyl(pyrimidinyl)azetidinecarboxamides as potent, orally bioavailable TGR5 agonists.

General Description

2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.

Synthesis

4-Methylpyridin-2-amine

695-34-1

2-Chloro-4-picoline

3678-62-4

a) Sodium nitrite (13.88 g, 200 mmol) was slowly added to a concentrated hydrochloric acid (200 mL) solution of 2-amino-4-methylpyridine (15.0 g, 139 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was poured into ice (500 g). The pH of the mixture was adjusted using concentrated ammonia to 8.0. Subsequently, the mixture was extracted with ether (3 x 300 mL). The combined ether layers were washed sequentially with deionized water (2 × 200 mL) and saturated brine (200 mL). The organic layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-chloro-4-methylpyridine (10.3 g, 58% yield) as a pale yellow oil. Mass spectrum (electrospray ionization) m/e 127.8 (M + H)+.

References

[1] Patent: US2002/91264, 2002, A1
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 2791 - 2796
[3] Acta Chemica Scandinavica, 1992, vol. 46, # 2, p. 157 - 162
[4] Patent: CN107151229, 2017, A. Location in patent: Paragraph 0023; 0027

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View Lastest Price from 2-Chloro-4-picoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-picoline pictures 2026-07-09 2-Chloro-4-picoline
3678-62-4
 $9.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-Chloro-4-picoline pictures 2026-06-30 2-Chloro-4-picoline
3678-62-4
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Chloro-4-Methylpyridine pictures 2026-05-28 2-Chloro-4-Methylpyridine
3678-62-4
 $19.10 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
4-Picoline, 2-chloro- Pyridine, 2-chloro-4-methyl- 2-CHLORO-GAMMA-PICOLINE 2-CHLOROPICOLINE 2-CHLORO-4-PICOLINE 2-chloro-4-methylpyrdine 2-CHLORO-4-PICOLINE 2-CHLORO-4-METHYLPYRIDINE 2-CHLORO-4-METHYLPYRIDINE (2-CHLORO-4-PICOLINE) HCPY1902-Chloro-4-picoline 2-Chloro-4-methylpyridine(2-Chloropicoline) 2-Chloro-4-picoline,98% 2-Chloro-4-Pilcoline 2-Chlor-4-methylpyridin 2-Chlor2-Chloro-4-picolineo-4-picoline 2-Chloro-4-mehyl pyridine 2-Chloro-4-methylpyridine > 5-bromopyridine-4-carbonitrile 2-Chloro-4-picoline ISO 9001：2015 REACH 2-Chloro-4-Methyle pyridine 2-Chloro-4-methylpyridine, 98% 2-CHLORO-4-METHYLPYRIDINE 3678-62-4 222-951-2 C6H6ClN Building Blocks HETERO CHLORIDE Halopyridines Chloropyridines Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Pyridine pyridine derivative pyridine series Chloropyridines Halopyridines Halides Pyridines
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