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Phospho-PDK1 (Ser241) Antibody

CAS No.
Chemical Name:
Phospho-PDK1 (Ser241) Antibody
Synonyms
Phospho-PDK1 (Ser241) Antibody
CBNumber:
CB75673419
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Phospho-PDK1 (Ser241) Antibody Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Phosphoinositide-dependent protein kinase 1 plays a central role in many signal transduction pathways including the activation of Akt and the PKC isoenzymes p70 S6 kinase and RSK. Through its effects on these kinases, PDK1 is involved in the regulation of a wide variety of processes, including cell proliferation, differentiation and apoptosis.Several serine sites are phosphorylated on PDK1 in unstimulated human embryo kidney 293 cells, as well as IGF-1 stimulated cells. Phosphorylation on the activation loop Ser241 by autophosphorylation is necessary for PDK1 activity.

References

[1] Belham, C. et al. (1999) Curr. Biol. 9, R93-R96.
[2] Toker, A. and Newton, A.C. (2000) Cell 103, 185-188.
[3] Williams, M.R. et al. (2000) Curr. Biol. 10, 439-448.
[4] Casamayor, A. et al. (1999) Biochem J 342 ( Pt 2), 287-92.

Phospho-PDK1 (Ser241) Antibody Preparation Products And Raw materials

Raw materials

Preparation Products

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Phospho-PDK1 (Ser241) Antibody
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