Source

Rabbit

Reactivity

Human

Background

βIG-H3 is a 683-amino acid secretory protein induced by TGF-β that plays a role in cell adhesion, differentiation, and apoptosis. βIG-H3 contains an internal cysteine-rich EMI domain followed by four fasciclin-1 domains and a carboxy terminal RGD domain. It contributes to cell adhesion through interactions with integrins as well as a number of extracellular matrix proteins including collagen, fibronectin, and laminin. ECM βIG-H3 is found in a wide variety of tissues. Mutations in the βIG-H3 gene as well as elevated protein levels are most notably associated with corneal dystrophies.

References

[1] Skonier, J. et al. (1992) DNA Cell Biol 11, 511-22.
[2] Skonier, J. et al. (1994) DNA Cell Biol 13, 571-84.
[3] Hashimoto, K. et al. (1997) Biochim Biophys Acta 1355, 303-14.
[4] Kim, J.E. et al. (2003) Oncogene 22, 2045-53.
[5] Kim, J.E. et al. (2002) Invest Ophthalmol Vis Sci 43, 656-61.
[6] Billings, P.C. et al. (2002) J Biol Chem 277, 28003-9.
[7] Hanssen, E. et al. (2003) J Biol Chem 278, 24334-41.
[8] Gibson, M.A. et al. (1997) J Histochem Cytochem 45, 1683-96.
[9] Billings, P.C. et al. (2000) Am J Respir Cell Mol Biol 22, 352-9.
[10] Gilbert, R.E. et al. (1998) Kidney Int 54, 1052-62.

Raw materials

Preparation Products