ChemicalBook >> CAS DataBase List >>Antide
Antide
- CAS No.
- 112568-12-4
- Chemical Name:
- Antide
- Synonyms
- Antide Acetate;iturelix;lyl-;ANTIDE;Orf 23541;Brn 4866881;Antide impurity;ANTIDE (iturelix);Iturelix, ORF 23541;Antide >=97% (HPLC)
- CBNumber:
- CB7665086
- Molecular Formula:
- C82H108ClN17O14
- Molecular Weight:
- 1591.3
- MDL Number:
- MFCD00133104
- MOL File:
- 112568-12-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-22 15:57:46
| Product description | Number | Pack Size | Price |
| Antide ≥97% (HPLC) | A8802 | 1mg | $198 |
| Antide | 441627 | 1mg | $523 |
| Antide | FA110401 | 25mg | $1889.25 |
| Antide | FA110401 | 50mg | $2267.5 |
| Antide | FA110401 | 100mg | $2843 |
| More product size | |||
| Boiling point | 1798.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.258±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| form | Solid |
| pka | 12.78±0.46(Predicted) |
| color | White to off-white |
| InChIKey | QRYFGTULTGLGHU-NBERXCRTSA-N |
| FDA UNII | 94055UOQ3Y |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360 |
| Precautionary statements | P201-P308+P313-P202-P280-P405-P501a |
| Hazard Codes | T |
| Risk Statements | 60 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | AY2961700 |
| HS Code | 3504009000 |
Antide price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A8802 | Antide ≥97% (HPLC) | 112568-12-4 | 1mg | $198 | 2022-05-15 | Buy |
| Usbiological | 441627 | Antide | 112568-12-4 | 1mg | $523 | 2026-06-03 | Buy |
| Biosynth | FA110401 | Antide | 112568-12-4 | 25mg | $1889.25 | 2026-06-04 | Buy |
| Biosynth | FA110401 | Antide | 112568-12-4 | 50mg | $2267.5 | 2026-06-04 | Buy |
| Biosynth | FA110401 | Antide | 112568-12-4 | 100mg | $2843 | 2026-06-04 | Buy |
Antide Chemical Properties,Uses,Production
Uses
Antide, is a GnRH and LH-RH antagonist, and with high anti-ovulatory and negligible histamine release activity.
Uses
Reversible inhibition of gonadotropin secretion and subsequent suppression of ovarian and testicular steroid secretio (gonadotropin releasing hormone antagonist).
Synthesis
Antide acetate was prepared as follows: the peptide intermediate was first treated with a suitable thiol to remove the Nps protecting group. It was then reacted with 2-benzyl-4-carboxypyridine in DMF in DCC as a coupling agent to acylate the Orn residue at the 5-position. After washing, the peptide resin was treated with piperidine to remove the Fmoc protecting group, followed by treatment with nicotinic acid and DIIC to acylate the D-Lys residue at the 6-position. Following cleavage and HPLC purification, the GnRH antagonist was tested and the peptide was considered effective in preventing ovulation in low-dose female mammals.
in vivo
Antide (subcutaneously; 1, 3, 6, 10 and 15 mg/kg; once or on 5 consecutive days) can induce a long-term chemical castration in adult male rats and cynomolgus monkeys[1].
| Animal Model: | Cynomolgus monkey and rat[1] |
| Dosage: | 1, 3, 6, 10 and 15 mg/kg |
| Administration: | Subcutaneous, once or on 5 consecutive days |
| Result: | Had a dose-dependent inhibitory effect on serum concentration of LH (only rat) and testosterone and on the weights of the testes, prostates and seminal vesicles. Achieved long-lasting castration-like effects at concentrations between 6 (less than or equal to 8 weeks) and 15 mg/kg (greater than 8 weeks) in the rat. Induced a prolonged inhibitory effect only at 15 mg/kg and the duration was only 2-3 weeks in the cynomolgus monkey. |
Description
Antide acetate (Ac-AA10-NH2) is an LHRH antagonist and represses LH and FSH release from the pituitary gland. Antide Mw is 1590.6 Dalton.??
Antide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 200)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Guangyuan Chemicl Co,Ltd | +86-17331189928 | admin@guyunchem.com | China | 615 | 58 |
| Adachibio Inc. | +81-8027837258; | sales@adachibio.com | Japan | 938 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 995 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8828 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
View Lastest Price from Antide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-21 | Antide acetate | $196.00-592.00 | 99.57% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | Antide
112568-12-4
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | Antide
112568-12-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- Antide acetate
- $196.00-592.00
- 99.57%
- TargetMol Chemicals Inc.
-
- Antide
112568-12-4
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Antide
112568-12-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
112568-12-4(Antide)Related Search:
L-Leucinamide hydrochloride
3-Pyridineethaneamine
L-Serinamide hydrochloride
(2R)-2-Aminopropanamide hydrochloride
Antide
2-(2-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE
H-ALA-ALA-ALA-NH2 HCL
3-NAPHTHALEN-2-YL-PROPIONALDEHYDE
H-D-PHE-NH2 HCL
AC-LYS-NH2 HCL
1of4
Ac-D-2-Nal-4-chloro-D-Phe-beta-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2
AC-DNAL-D: P-CLPHE-DPAL-SER-LYS: NICOTINOYL-DLYS: NICOTINOYL-LEU-LYS: ISOPROPYL-PRO-DALA-NH2
Brn 4866881
D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N(sup 6)-(3-pyridinylcarbonyl)-L-lysyl-N(sup 6)-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N(sup 6)-(1-methylethyl)-L-lysyl-L-prolyl-
D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N6-(3-pyridinylcarbonyl)-L-lysyl-N6-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-
Orf 23541
Ac-D-2-Nal-4-chloro-D-Phe-b-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2
Iturelix, ORF 23541
Ac-D-2-Nal-p-chloro-D-Phe-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)
-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2
ANTIDE (iturelix)
Antide, Iturelix, ORF 23541
-(3-pyridinylcarbonyl)-d-lysyl-l-leucyl-n(sup6)-(1-methylethyl)-l-lysyl-l-pro
3-pyridinyl)-d-alanyl-l-seryl-n(sup6)-(3-pyridinylcarbonyl)-l-lysyl-n(sup6)
lyl-
ANTIDE
AC-(D-NAL)-(D-P-CL-PHE)-(D-PAL)-SER-LYS(NICOTINOYL)-[D-LYS(NICOTINOYL)]-LEU-LYS(ISOPROPYL)-PRO-[D-ALA]-NH2
AC-D-ALA(2-NAPHTHYL)-D-PHE(4-CL)-D-ALA(3'-PYRIDYL)-SER-LYS(NICOTINOYL)-D-LYS(NICOTINOYL)-LEU-LYS(ISOPROPYL)-PRO-D-ALA-NH2
AC-D-2-NAL-P-CHLORO-D-PHE-BETA-(3-PYRIDYL)-D-ALA-SER-LYS(NICOTINOYL)-D-LYS(NICOTINOYL)-LEU-LYS(ISOPROPYL)-PRO-D-ALA-NH2
Ac-D-2-Nal-p-chloro-D-Phe-.beta.-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2
Antide impurity
Antide Acetate, Iturelix
Antide >=97% (HPLC)
Peptides Antide Acetate
N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-(((R)-1-amino-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-6-(isopropylamino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-7-(4-chlorobenzyl)-13-(hydroxymethyl)-4-(naphthalen-2-ylmethyl)-16-(4-(nicotinamido)butyl)-2,5,8,11,14,17-hexaoxo-10-(pyridin-3-ylmethyl)-3,6,9,12,15,18-hexaazatricosan-23-yl)nicotinamide
N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-(((R)-1-Amino-1-oxo-propan-2-yl)-carbamoyl)-pyrrolidin-1-yl)-6-(isopropylamino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamoyl)-7-(4-chlorobenzyl)-13-(hydroxymethyl)-4-(naphthalen-2-ylmethyl)-16-(4-(nicotincarboxcarboxcarboxamido)butyl)-2,5,8,11,14,17-hexaoxo-10-(pyridin-3-ylmethyl)-3,6,9,12,15,18-hexaazatricosan-23-yl)-pyridin-3-carboxamide
Antide Acetate
iturelix
112568-12-4
112568-40-6
C82H108ClN17O14
LH-RH
Peptides
Releasing Factors
Biochemicals and Reagents
Amino Acids and Peptides
BioChemical
hormones
Peptide
LH-RH
LH-RHPeptides for Cell Biology
Neuropeptides
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