Etoxadrol
- CAS No.
- 28189-85-7
- Chemical Name:
- Etoxadrol
- Synonyms
- Nsc288020;Etoxadrol;Piperidine, 2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)-;Piperidine, 2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)-, (+)-;(S)-2-[(2S)-2-Ethyl-2α-phenyl-1,3-dioxolan-4β-yl]piperidine;Piperidine, 2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)-
- CBNumber:
- CB81178683
- Molecular Formula:
- C16H23NO2
- Molecular Weight:
- 261.36
- MDL Number:
- MFCD00864446
- MOL File:
- 28189-85-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-(2-ETHYL-2-PHENYL-1,3-DIOXOLAN-4-YL)PIPERIDINE 95.00% | CHM1006646 | 5MG | $501.11 |
| Boiling point | 404.61°C (rough estimate) |
|---|---|
| Density | 1.0086 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| pka | 9.57±0.10(Predicted) |
| Water Solubility | 0.65g/L(20 ºC) |
| FDA UNII | SIQ2UWR01K |
Etoxadrol Chemical Properties,Uses,Production
Uses
Etoxadrol (CL-1848C) is a potent, high-affinity N-methyl-D-aspartic acid (NMDA) antagonist. Etoxadrol is used in the anaesthetic and anaesthesia research community to suppress or relieve pain[1].
in vivo
Etoxadrol (CL-1848C) (100.0 mg/kg; i.h.; once) produces marked stimulation and ataxia in mice[2].
Etoxadrol (0-20 mg/kg; i.v.; once) decreases brain monoamine concentrations after 4 h injection[3].
| Animal Model: | Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm[2] |
| Dosage: | 100.0 mg/kg |
| Administration: | Subcutaneous injection, 30 min |
| Result: | Produced marked stimulation and ataxia. |
| Animal Model: | Male CFE rats weighing 110-175 g (average 130 g)[3] |
| Dosage: | 5, 10, and 20 mg/kg |
| Administration: | Intravenous injection, once |
| Result: | Significantly lowered brain serotonin, DA (dopamine), and NE (norepinephrine) concentrations at 4 h. |
References
[1] A Thurkauf, et al. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J Med Chem. 1988 Dec;31(12):2257-63. DOI:10.1021/jm00120a004
[2] A H Tang, et al. Analgetic activities of etoxadrol in the rhesus monkey and in mice. Anesth Analg. 1973 Jul-Aug;52(4):577-83. PMID:4197876
[3] Y F Sung, et al. Effects of intravenous anesthetics on brain monoamines in the rat. Anesthesiology. 1973 Nov;39(5):478-87. DOI:10.1097/00000542-197311000-00004
Etoxadrol Preparation Products And Raw materials
Raw materials
Preparation Products
Etoxadrol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29845 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | -- | sales@biosynth.com | China | 6051 | 58 |
