BRL 6231
- CAS No.
- 47326-86-3
- Chemical Name:
- BRL 6231
- Synonyms
- BRL 6231;WR-99210;Antifolate,Inhibitor,Bacterial,WR 99210,inhibit,WR99210,WR-99210;6,6-dimethyl-1-(3-(2,4,5-trichlorophenoxy)propoxy)-1,6-dihydro-1,3,5-triazine-2,4-diamine;1,6-Dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine;5-[3-(2,4,5-Trichlorophenoxy)propoxy]-6,6-dimethyl-5,6-dihydro-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, 1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-;1-[3-[(2,4,5-Trichlorophenyl)oxy]propoxy]-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine
- CBNumber:
- CB81359536
- Molecular Formula:
- C14H18Cl3N5O2
- Molecular Weight:
- 394.68
- MDL Number:
- MFCD01679034
- MOL File:
- 47326-86-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| WR99210 99.10% | CS-0065315 | 5mg | $188 |
| WR99210 99.10% | CS-0065315 | 10mg | $292 |
| WR99210 99.10% | CS-0065315 | 25mg | $625 |
| WR99210 99.10% | CS-0065315 | 50mg | $970 |
| WR99210 99.10% | CS-0065315 | 100mg | $1504 |
| Boiling point | 519.7±60.0 °C(Predicted) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble0.2mg/mL, clear (warmed) |
| form | powder |
| pka | 8.48±0.40(Predicted) |
| color | white to off-white |
| InChI | 1S/C14H18Cl3N5O2/c1-14(2)21-12(18)20-13(19)22(14)24-5-3-4-23-11-7-9(16)8(15)6-10(11)17/h6-7H,3-5H2,1-2H3,(H4,18,19,20,21) |
| InChIKey | MJZJYWCQPMNPRM-UHFFFAOYSA-N |
| SMILES | CC1(C)N=C(N)N=C(N)N1OCCCOc2cc(Cl)c(Cl)cc2Cl |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
BRL 6231 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0065315 | WR99210 99.10% | 47326-86-3 | 5mg | $188 | 2026-06-04 | Buy |
| ChemScene | CS-0065315 | WR99210 99.10% | 47326-86-3 | 10mg | $292 | 2026-06-04 | Buy |
| ChemScene | CS-0065315 | WR99210 99.10% | 47326-86-3 | 25mg | $625 | 2026-06-04 | Buy |
| ChemScene | CS-0065315 | WR99210 99.10% | 47326-86-3 | 50mg | $970 | 2026-06-04 | Buy |
| ChemScene | CS-0065315 | WR99210 99.10% | 47326-86-3 | 100mg | $1504 | 2026-06-04 | Buy |
BRL 6231 Chemical Properties,Uses,Production
Uses
WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii[1][2][3].
Biochem/physiol Actions
WR99210 is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (DHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mutant dihydrofolate reductases.
in vivo
WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model[1].
| Animal Model: | Male mice (T. gondii-infected)[1]. |
| Dosage: | 1.25 mg/kg |
| Administration: | Intraperitoneal injection; single daily for 5 days. |
| Result: | Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5. |
References
[1] Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7. DOI:10.1128/AAC.49.8.3463-3467.2005
[2] Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41. DOI:10.1073/pnas.182295999
[3] Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. DOI:10.1128/AAC.00308-09
BRL 6231 Preparation Products And Raw materials
Raw materials
Preparation Products
BRL 6231 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 19372819560 | Sales@ATKchemical.com | China | 9625 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Huansheng Meisen Pharmaceutical Technology (Shandong) Co., Ltd | 0531-88762217 18301471076 | sales@acespharma.com | China | 3860 | 58 |
