deoxyfructosazine
- CAS No.
- 17460-13-8
- Chemical Name:
- deoxyfructosazine
- Synonyms
- 2,5-Deoxyfructosazine (hydrochloride);NSC 270912;deoxyfructosazine;2,5-Deoxyfructosazine;Glucosamine Impurity C;Glucosamine EP Impurity C;Glucosamine sulfate Impurity 12; Glucosamine sulphate Impurity C;Glucosamine sulfate EP impurity C;Glucosamine EP Impurity C (Deoxy-Fructosazine)
- CBNumber:
- CB81382147
- Molecular Formula:
- C12H20N2O7
- Molecular Weight:
- 304.3
- MDL Number:
- MFCD18382251
- MOL File:
- 17460-13-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2,5-Deoxyfructosazine (hydrochloride) ≥98% | 18662 | 1mg | $152 |
| 2,5-Deoxyfructosazine (hydrochloride) ≥98% | 18662 | 5mg | $417 |
| 2,5-Deoxyfructosazine (hydrochloride) ≥98% | 18662 | 1mg | $138 |
| 2,5-Deoxyfructosazine (hydrochloride) ≥98% | 18662 | 500μg | $60 |
| 2,5-Deoxyfructosazine >95%(HPLC) | TRC-D235810-5MG | 5mg | $422 |
| More product size | |||
| Melting point | 157-160°C |
|---|---|
| Boiling point | 712.0±60.0 °C(Predicted) |
| Density | 1.582 |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Sonicated) |
| form | Solid |
| pka | 11.86±0.20(Predicted) |
| color | Pale Brown to Brown |
| Major Application | pharmaceutical small molecule |
| InChI | InChI=1S/C12H20N2O7/c15-4-9(18)8(17)1-6-2-14-7(3-13-6)11(20)12(21)10(19)5-16/h2-3,8-12,15-21H,1,4-5H2/t8-,9+,10+,11+,12+/m0/s1 |
| InChIKey | FBDICDJCXVZLIP-VSSNEEPJSA-N |
| SMILES | [C@H](C1=NC=C(C[C@H](O)[C@H](O)CO)N=C1)(O)[C@H](O)[C@H](O)CO |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | WGK 3 |
| HS Code | 29072990 |
| Storage Class | 11 - Combustible Solids |
deoxyfructosazine price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18662 | 2,5-Deoxyfructosazine (hydrochloride) ≥98% | 17460-13-8 | 1mg | $152 | 2026-04-30 | Buy |
| Cayman Chemical | 18662 | 2,5-Deoxyfructosazine (hydrochloride) ≥98% | 17460-13-8 | 5mg | $417 | 2026-04-30 | Buy |
| Cayman Chemical | 18662 | 2,5-Deoxyfructosazine (hydrochloride) ≥98% | 17460-13-8 | 1mg | $138 | 2024-03-01 | Buy |
| Cayman Chemical | 18662 | 2,5-Deoxyfructosazine (hydrochloride) ≥98% | 17460-13-8 | 500μg | $60 | 2023-01-06 | Buy |
| TRC | TRC-D235810-5MG | 2,5-Deoxyfructosazine >95%(HPLC) | 17460-13-8 | 5mg | $422 | 2026-06-03 | Buy |
deoxyfructosazine Chemical Properties,Uses,Production
Description
2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50 = ~1.25 mM).
Chemical Properties
Tan Solid
Uses
Contained in tobacco flavor additives.
Synthesis
Step 1: 5g fructose and 15g ammonium chloride were weighed and dissolved in 500g distilled water and stirred to make the mixture homogeneous. Step 2: Place the prepared aqueous solution of fructose and additional nitrogen source in a reaction vessel, set the reaction temperature at 120C and the reaction time at 2 hours. At the end of the reaction, a small amount of the mixture of 2,5-deoxyfructosazine crude product was removed and analyzed. A conversion of fructose of 100% and a molar yield of 2,5-deoxyfructosazine of 60% were obtained. Step 3: The mixture of 2,5-deoxyfructosazine crude product was concentrated by spinning, 300 ml of ethanol and formic acid (v/v=1:6) was added, filtered, insoluble impurities were removed, and the filtrate was left to stand for 10 hours, and the product 2,5-deoxyfructosazine was obtained by crystallization, and the crystalline product was obtained with a purity ≥98%.
References
[1] NATHALY HENRY. Synthesis of water-compatible imprinted polymers of in situ produced fructosazine and 2,5-deoxyfructosazine.[J]. Talanta, 2012, 99: 816-823. DOI: 10.1016/j.talanta.2012.07.035
[2] RODGMAN A, PERFETTI T. The Chemical Components of Tobacco and Tobacco Smoke[C]. 2008: 0. DOI: 10.1201/b13973
[3] AIPING ZHU . 2,5-Deoxyfructosazine, a d-glucosamine derivative, inhibits T-cell interleukin-2 production better than d-glucosamine[J]. Carbohydrate Research, 2007, 342 18: Pages 2745-2749. DOI: 10.1016/j.carres.2007.08.025
[4] TOMOKO SHIMAMURA. Reduction mechanism of tetrazolium salt XTT by a glucosamine derivative.[J]. Bioscience, Biotechnology, and Biochemistry, 2003, 67 2: 295-299. DOI: 10.1271/bbb.67.295
[5] K SUMOTO. Formation of pyrazine derivatives from D-glucosamine and their deoxyribonucleic acid (DNA) strand breakage activity.[J]. Chemical & pharmaceutical bulletin, 1991, 39 3: 792-794. DOI: 10.1248/cpb.39.792
deoxyfructosazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Sinco Pharmachem (ShenZhen) R&D Co., Ltd. | +undefined18603013401 | jack.lin@sincopharmachem.com | China | 9996 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +8613670046396 | export03@qcsrm.com | China | 24342 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 15111215862 18229892877 | 3062105966@qq.com | China | 5433 | 58 |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17721492509 17721492509 | 460170712@qq.com | China | 4945 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14100 | 59 |
View Lastest Price from deoxyfructosazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | 2,5-Deoxyfructosazine (hydrochloride)
17460-13-8
|
$129.00-248.00 | 10g | TargetMol Chemicals Inc. |
-
- 2,5-Deoxyfructosazine (hydrochloride)
17460-13-8
- $129.00-248.00
- TargetMol Chemicals Inc.
