ChemicalBook >> CAS DataBase List >>Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
- CAS No.
- 131707-24-9
- Chemical Name:
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
- Synonyms
- Si-5;Ethyl 6-broMo-5-hydroxy-1-Methyl-2-((phenylthio)Methyl)-1H-Indole-3-carboxylate;Si 5;Ethyl 6-bromo-5;Abidol Impurity;Abidol Impurity 18;Si 5 (pharmaceutical);Abbidore intermediate 5;Impurities in Arbidol908;Ethyl 6-bromo-5-hydroxy-1-methyl-2-((phenylthio)methyl)
- CBNumber:
- CB81417913
- Molecular Formula:
- C19H18BrNO3S
- Molecular Weight:
- 420.32
- MDL Number:
- MFCD00378136
- MOL File:
- 131707-24-9.mol
- MSDS File:
- SDS
Last updated:2026-05-28 03:36:55
| Product description | Number | Pack Size | Price |
| Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | FE16065 | 50g | $250 |
| Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | FE16065 | 100g | $394 |
| Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | FE16065 | 250g | $787.5 |
| Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | FE16065 | 500g | $1305 |
| Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | FE16065 | 1000g | $1890 |
| More product size | |||
| Melting point | >192°C (dec.) |
|---|---|
| Boiling point | 570.6±50.0 °C(Predicted) |
| Density | 1.44±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Sparingly, Heated) |
| pka | 7.60±0.40(Predicted) |
| form | Solid |
| color | White to Light Brown |
| InChI | InChI=1S/C19H18BrNO3S/c1-3-24-19(23)18-13-9-17(22)14(20)10-15(13)21(2)16(18)11-25-12-7-5-4-6-8-12/h4-10,22H,3,11H2,1-2H3 |
| InChIKey | DAFNNZWQTJQQAP-UHFFFAOYSA-N |
| SMILES | N1(C)C2=C(C=C(O)C(Br)=C2)C(C(OCC)=O)=C1CSC1=CC=CC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H332-H319-H335-H302-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P |
| HazardClass | IRRITANT |
| REACH Registrations | Active |
Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FE16065 | Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | 131707-24-9 | 50g | $250 | 2026-06-04 | Buy |
| Biosynth | FE16065 | Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | 131707-24-9 | 100g | $394 | 2026-06-04 | Buy |
| Biosynth | FE16065 | Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | 131707-24-9 | 250g | $787.5 | 2026-06-04 | Buy |
| Biosynth | FE16065 | Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | 131707-24-9 | 500g | $1305 | 2026-06-04 | Buy |
| Biosynth | FE16065 | Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate | 131707-24-9 | 1000g | $1890 | 2026-06-04 | Buy |
Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate Chemical Properties,Uses,Production
Uses
6-Bromo-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic Acid Ethyl Ester is used to prepare anti-hepatitis B virus activities of Et bromohydroxyindolecarboxylates.
Synthesis
110543-98-1
108-98-5
131707-24-9
To 900 mL of methanol was added 30 g of sodium hydroxide (0.75 mol) and stirred until completely dissolved to form a clarified solution. Subsequently, 39.7 g of benzenethiol (0.36 mol) was added to this solution and the reaction was continued with stirring for 2 hours. Next, 130 g of ethyl 1-methyl-2-(bromomethyl)-5-acetoxy-6-bromoindole-3-carboxylate (0.30 mol) was added and the reaction was continued with stirring for 3 hours. Upon completion of the reaction, the reaction mixture was neutralized with acetic acid and a large amount of solid was observed to precipitate. The mixture was allowed to stand, the solid was collected by filtration and the filter cake was washed with cold water. Finally, the crude product was recrystallized from ethyl acetate and dried to give 114.5 g of ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylthiomethyl)indole-3-carboxylate in 90.8% yield.
References
[1] Pharmaceutical Chemistry Journal, 1993, vol. 27, # 1, p. 75 - 76
[2] Khimiko-Farmatsevticheskii Zhurnal, 1993, vol. 27, # 1, p. 70 - 71
[3] Patent: CN106083691, 2016, A. Location in patent: Paragraph 0025; 0059
[4] Patent: US5198552, 1993, A
Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 193)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 6002 | 58 |
| Nanjing Fred Technology Co., Ltd | +86-25-84696168 +86-15380713688 | Austin@fredbio.com | China | 2428 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Casorganics US Corp | +17326109938 | sales@casorganics.com | CHINA | 174 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
View Lastest Price from Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-01 | Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
131707-24-9
|
1kg | 98.5% | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2024-11-26 | Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
131707-24-9
|
1kg | 98%HPLC | 20 tons | Nanjing Fred Technology Co., Ltd | ||
 |
2021-07-06 | Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
131707-24-9
|
1kg | 98 | 50MT | Jinan Shengqi pharmaceutical Co,Ltd |
-
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
131707-24-9
- 98.5%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
131707-24-9
- 98%HPLC
- Nanjing Fred Technology Co., Ltd
-
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
131707-24-9
- $0.00
- 98
- Jinan Shengqi pharmaceutical Co,Ltd
131707-24-9(Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate)Related Search:
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Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)ind...
Impurities in Arbidol908
Si-5
Ethyl 6-broMo-5-hydroxy-1-Methyl-2-((phenylthio)Methyl)-1H-Indole-3-carboxylate
Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylat
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Abbidore intermediate 5
6-bromo-5-hydroxy-1-methyl-2- (phenylsulfanylmethyl)indole- 3-carboxylate
Abidol Impurity
Ethyl 6-bromo-5-hydroxy-2-phenylthiomethyl-1-methylindol-3-carboxylate
131707-24-9
31707-24-9
C19H18BrNO3S
