2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE
- CAS No.
- 230615-52-8
- Chemical Name:
- 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE
- Synonyms
- 2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride;2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine hydrochloride;hydrochloride (1:1);10-azatricyclo[6.3.1.02?]dodeca-2(7),3,5-triene;2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine HCl;2,3,4,5-tetrahydro-1H-1,5-methano-3-benzazepin-3-ium chloride;2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE;2,3,4,5-tetrahydro-1,5-Methano-1H-3-benzazepine,hydrochlorid...;2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine (hydrochlortde);1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-, hydrochloride
- CBNumber:
- CB81472880
- Molecular Formula:
- C11H13N.HCl
- Molecular Weight:
- 195.69
- MDL Number:
- MFCD11042279
- MOL File:
- 230615-52-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 289836 | 500mg | $360 |
| 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 289836 | 1g | $468 |
| 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 289836 | 2g | $656 |
| 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 289836 | 5g | $1055 |
| 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 289836 | 10g | $1646 |
| More product size | |||
| Melting point | >230°C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Pale Yellow |
| InChI | InChI=1/C11H13N.ClH/c1-2-4-11-9-5-8(6-12-7-9)10(11)3-1;/h1-4,8-9,12H,5-7H2;1H/t8-,9+; |
| InChIKey | WWJDLIUDQHFAGC-UFIFRZAQNA-N |
| SMILES | C1[C@@]2(C3=C(C=CC=C3)[C@@]([H])(C2)CN1)[H].Cl |&1:1,8,r| |
| FDA UNII | 5F3AKZ2PNU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| REACH Registrations | Active |
2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 289836 | 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 230615-52-8 | 500mg | $360 | 2026-06-03 | Buy |
| Usbiological | 289836 | 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 230615-52-8 | 1g | $468 | 2026-06-03 | Buy |
| Usbiological | 289836 | 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 230615-52-8 | 2g | $656 | 2026-06-03 | Buy |
| Usbiological | 289836 | 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 230615-52-8 | 5g | $1055 | 2026-06-03 | Buy |
| Usbiological | 289836 | 2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine hydrochloride Asreported | 230615-52-8 | 10g | $1646 | 2026-06-03 | Buy |
2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
2,3,4,5-Tetrahydro-1H-1,5-methano-3-benzazepine Hydrochloride is used in the preparation of the main band impurity of Varenicline (V098490), a nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation.
Synthesis
230615-48-2
230615-52-8
The general procedure for the synthesis of 2,3,4,5-tetrahydro-3-benzyl-1,5-methano-1H-3-benzazepine hydrochloride from 2,3,4,5-tetrahydro-3-benzyl-1,5-methanolbenzo[d]azepine hydrochloride is as follows: methanol hydrochloride (116.6 g, 13.8%) was slowly added to 10-benzyl-10-azabenzotriene at 0°C to 5°C [ 6.3.1.02,7]dodeca-2(7),3,5-triene (100 g) in a methanol (600 ml) suspension. Subsequently, the reaction mixture was subjected to hydrogenation reaction catalyzed by 20% palladium hydroxide (26 g) under hydrogen pressure of 5 to 6 kg/cm2 at 20°C to 40°C for 3 to 6 hours. The reaction process was monitored by HPLC. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was distilled under reduced pressure to remove the solvent. Dichloromethane (500 ml) was added to the residue and the solvent was again completely evaporated under reduced pressure to give the crude product. The crude product was purified by recrystallization with acetone (450 ml) to finally obtain high purity 10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene hydrochloride (HPLC purity 98.23%, yield 89.24%).
References
[1] Patent: US2009/318695, 2009, A1. Location in patent: Page/Page column 9
[2] Patent: WO2010/23561, 2010, A1. Location in patent: Page/Page column 16
2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-17 | 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE
230615-52-8
|
$2.00-5.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-01-04 | 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE
230615-52-8
|
99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd | |||
![2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine HCl pictures](/ProductImageEN/2024-02/Small/9a495740-88c8-4207-b4f9-3697f3a24934.png) |
2024-02-13 | 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine HCl
230615-52-8
|
$1200.00 | 1g | 98 | 500 Kg | R&D Scientific Inc. |
-
- 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE
230615-52-8
- $2.00-5.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE
230615-52-8
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine HCl
230615-52-8
- $1200.00
- 98
- R&D Scientific Inc.
