1-aminonaphthalene-2-carboxylic acid
- CAS No.
- 4919-43-1
- Chemical Name:
- 1-aminonaphthalene-2-carboxylic acid
- Synonyms
- Pazopanib Impurity 87;1-Amino-2-naphthoic acid;1-aminophthalene-2-carboxylic acid;1-Amino-2-naphthalenecarboxylic acid;1-aminonaphthalene-2-carboxylic acid;2-Naphthalenecarboxylic acid, 1-amino-
- CBNumber:
- CB81630185
- Molecular Formula:
- C11H9NO2
- Molecular Weight:
- 187.19
- MDL Number:
- MFCD11193636
- MOL File:
- 4919-43-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Amino-2-naphthoic acid 95% | AS37665 | 1g | $173 |
| 1-Amino-2-naphthoic acid 95% | AS37665 | 5g | $548 |
| 1-Aminonaphthalene-2-carboxylic acid | 143868 | 1.00g | $70 |
| 1-Aminonaphthalene-2-carboxylic acid | 143868 | 5.00g | $310 |
| 1-Aminonaphthalene-2-carboxylic acid | 143868 | 25.00g | $1112 |
| More product size | |||
1-aminonaphthalene-2-carboxylic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS37665 | 1-Amino-2-naphthoic acid 95% | 4919-43-1 | 1g | $173 | 2026-06-04 | Buy |
| Activate Scientific | AS37665 | 1-Amino-2-naphthoic acid 95% | 4919-43-1 | 5g | $548 | 2026-06-04 | Buy |
| Matrix Scientific | 143868 | 1-Aminonaphthalene-2-carboxylic acid | 4919-43-1 | 1.00g | $70 | 2026-05-18 | Buy |
| Matrix Scientific | 143868 | 1-Aminonaphthalene-2-carboxylic acid | 4919-43-1 | 5.00g | $310 | 2026-05-18 | Buy |
| Matrix Scientific | 143868 | 1-Aminonaphthalene-2-carboxylic acid | 4919-43-1 | 25.00g | $1112 | 2026-05-18 | Buy |
1-aminonaphthalene-2-carboxylic acid Chemical Properties,Uses,Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 37, p. 745, 1994 DOI: 10.1021/jm00032a007
Synthesis
103987-83-3
4919-43-1
General procedure for the synthesis of 1-amino-2-naphthalenecarboxylic acid from 1-nitro-2-naphthalenecarboxylic acid: 1-nitro-2-naphthalenecarboxylic acid (17.3 g), acetic acid (2 g), and a Pd/C catalyst (1.83 g, 10 wt% Pd) were suspended in THF (339 mL) in reactor A. The reaction was carried out in the same manner as the reaction. The reaction mixture was degassed and pressurized with hydrogen (25 psig). The mixture was stirred and reacted for 10 hours under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth (6 g) and the filter cake was washed with THF (51 mL). The combined filtrates were concentrated to about 40 mL and then cooled at 0-5 °C. Water (143 mL) was added to the concentrate to induce crystallization of the product. 1-Amino-2-naphthalenecarboxylic acid was isolated by filtration, washed with water (100 mL), and dried to give 13.35 g of product in 92.2% yield, 99.5% liquid phase purity (LCAP), and 98.7% wt. purity.
References
[1] Patent: WO2017/58691, 2017, A1. Location in patent: Page/Page column 13
[2] Chemische Berichte, 1918, vol. 51, p. 1243
1-aminonaphthalene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3801 | 58 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49940 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
View Lastest Price from 1-aminonaphthalene-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-12 | 1-aminonaphthalene-2-carboxylic acid
4919-43-1
|
$1.00-2.10 | 1KG | 99% | 20000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-13 | 1-aminonaphthalene-2-carboxylic acid
4919-43-1
|
$5.50 | 1KG | 98% | 1kg-100kg | Career Henan Chemical Co |
-
- 1-aminonaphthalene-2-carboxylic acid
4919-43-1
- $1.00-2.10
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 1-aminonaphthalene-2-carboxylic acid
4919-43-1
- $5.50
- 98%
- Career Henan Chemical Co
