4-Azabenzimidazole
- CAS No.
- 273-21-2
- Chemical Name:
- 4-Azabenzimidazole
- Synonyms
- 4H-Imidazo[4,5-b]pyridine;PBTFL44;1-deazapurine;3,4-diazaindole;4-AZABENZIMIDAZOLE;7-azabenzimidazole;TIMTEC-BB SBB004292;4-Aza-1H-benzimidazole;Imidazo(4,5-b)pyridine;4-AZABENZIMIDAZOLE 99%
- CBNumber:
- CB8165215
- Molecular Formula:
- C6H5N3
- Molecular Weight:
- 119.12
- MDL Number:
- MFCD00005579
- MOL File:
- 273-21-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Azabenzimidazole 99% | A93607 | 1g | $98.2 |
| 4-Azabenzimidazole 99% | A93607 | 5g | $347 |
| 1H-Imidazo[4,5-b]pyridine >96% | OR27927 | 250mg | $21 |
| 1H-Imidazo[4,5-b]pyridine >96% | OR27927 | 1g | $24 |
| 1H-Imidazo[4,5-b]pyridine >96% | OR27927 | 5g | $112 |
| More product size | |||
| Melting point | 148-151 °C (lit.) |
|---|---|
| Boiling point | 140-150°C/0.1mm |
| Density | 1.2058 (rough estimate) |
| refractive index | 1.5589 (estimate) |
| Flash point | 140-150°C/0.1mm |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in dimethylformamide. |
| form | powder |
| pka | 8.46±0.20(Predicted) |
| Appearance | Off-white to light brown Solid |
| BRN | 2600 |
| InChI | 1S/C6H5N3/c1-2-5-6(7-3-1)9-4-8-5/h1-4H,(H,7,8,9) |
| InChIKey | GAMYYCRTACQSBR-UHFFFAOYSA-N |
| SMILES | c1cnc2nc[nH]c2c1 |
| CAS DataBase Reference | 273-21-2(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazo[4,5-b]pyridine (273-21-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NJ5108000 | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,> 200mg/kg (200mg/kg),Journal of Medicinal Chemistry. Vol. 6, Pg. 480, 1963. | |||||||||
| NFPA 704 |
|
4-Azabenzimidazole price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A93607 | 4-Azabenzimidazole 99% | 273-21-2 | 1g | $98.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | A93607 | 4-Azabenzimidazole 99% | 273-21-2 | 5g | $347 | 2023-06-20 | Buy |
| Apolloscientific | OR27927 | 1H-Imidazo[4,5-b]pyridine >96% | 273-21-2 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR27927 | 1H-Imidazo[4,5-b]pyridine >96% | 273-21-2 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR27927 | 1H-Imidazo[4,5-b]pyridine >96% | 273-21-2 | 5g | $112 | 2026-06-04 | Buy |
4-Azabenzimidazole Chemical Properties,Uses,Production
Chemical Properties
yellow to light brown powder
Uses
4-Azabenzimidazole is used in the preparation of imidazo[4,5-b]pyridine 4-oxide. It is also used as a reagent to prepare benzoylmethyl-substituted azoles which are inhibitors of nitric oxide synthase with antioxidant properties.
Definition
ChEBI: The [4,5-b]-fused isomer of imidazopyridine.
Synthesis
452-58-4
122-51-0
273-21-2
The general procedure for the synthesis of 4-azabenzimidazole from 2,3-diaminopyridine and triethyl orthoformate was as follows: to evaluate the catalytic performance of different γ-Fe2O3@SiO2-HA catalysts, a catalytic amount of γ-Fe2O3@SiO2-HA (2.5 mol%) was added to a glass flask containing 1.2 mmol of triethyl orthoformate and stirred at room temperature for 15 minutes. Subsequently, 2 mmol of 2,3-diaminopyridine was added to the reaction mixture and the reaction was continued until a predetermined time was reached. The progress of the reaction was monitored by thin layer chromatography (TLC) and the unfolding agent was a solvent mixture of hexane and ethyl acetate (ratio 4:1 or 7:3 for diamines). Upon completion of the reaction, 5 mL of dichloromethane (ethyl acetate was used for entries 8 and 9) was added to the mixture, followed by separation of the catalyst by an external magnet for subsequent use. Finally, the resulting solution was concentrated on a rotary evaporator to give the purified 4-azabenzimidazole solid product.
References
[1] Asian Journal of Chemistry, 2013, vol. 25, # 6, p. 3446 - 3448
[2] Journal of Molecular Structure, 2012, vol. 1027, p. 156 - 161
4-Azabenzimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9333 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
View Lastest Price from 4-Azabenzimidazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 4-Azabenzimidazole
273-21-2
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-01-03 | 4-Azabenzimidazole
273-21-2
|
$1.00 | 1KG | 99% | 10000KGS | Career Henan Chemical Co |
-
- 4-Azabenzimidazole
273-21-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-Azabenzimidazole
273-21-2
- $1.00
- 99%
- Career Henan Chemical Co
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