ethyl 4-amino-6-chloronicotinate
- CAS No.
- 380626-81-3
- Chemical Name:
- ethyl 4-amino-6-chloronicotinate
- Synonyms
- ethyl 4-amino-6-chloronicotite;ethyl 4-amino-6-chloronicotinate;4-aMino-6-chloro Nicotinic acid ethyl;ethyl 4-aMino-6-chloropyridine-3-carboxylate;4-aMino-6-chloropyridine-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 4-aMino-6-chloro-, ethyl ester
- CBNumber:
- CB82047759
- Molecular Formula:
- C8H9ClN2O2
- Molecular Weight:
- 200.62
- MDL Number:
- MFCD00834975
- MOL File:
- 380626-81-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl 4-amino-6-chloronicotinate | 307240 | 250.00mg | $62 |
| Ethyl 4-amino-6-chloronicotinate | 307240 | 1.00g | $71 |
| Ethyl 4-amino-6-chloronicotinate | 307240 | 5.00g | $211 |
| Ethyl 4-amino-6-chloronicotinate | 113968 | 250.00mg | $58 |
| Ethyl 4-amino-6-chloronicotinate | 113968 | 1.00g | $69 |
| Boiling point | 335.8±37.0 °C(Predicted) |
|---|---|
| Density | 1.326±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 2.75±0.42(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C8H9ClN2O2/c1-2-13-8(12)5-4-11-7(9)3-6(5)10/h3-4H,2H2,1H3,(H2,10,11) |
| InChIKey | OAQIVHCEAFDMTK-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=CC(N)=C1C(OCC)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
ethyl 4-amino-6-chloronicotinate price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 307240 | Ethyl 4-amino-6-chloronicotinate | 380626-81-3 | 250.00mg | $62 | 2026-05-19 | Buy |
| Matrix Scientific | 307240 | Ethyl 4-amino-6-chloronicotinate | 380626-81-3 | 1.00g | $71 | 2026-05-19 | Buy |
| Matrix Scientific | 307240 | Ethyl 4-amino-6-chloronicotinate | 380626-81-3 | 5.00g | $211 | 2026-05-19 | Buy |
| Matrix Scientific | 113968 | Ethyl 4-amino-6-chloronicotinate | 380626-81-3 | 250.00mg | $58 | 2026-05-18 | Buy |
| Matrix Scientific | 113968 | Ethyl 4-amino-6-chloronicotinate | 380626-81-3 | 1.00g | $69 | 2026-05-18 | Buy |
ethyl 4-amino-6-chloronicotinate Chemical Properties,Uses,Production
Uses
Ethyl 4-Amino-6-chloronicotinate is a useful reagent in the preparation of biologically active small molecules with pharmaceutical application.
Synthesis
![3-Pyridinecarboxylic acid, 6-chloro-4-[[(2,4-dimethoxyphenyl)methyl]amino]-, ethyl ester](/CAS/20210111/GIF/1588423-42-0.gif)
1588423-42-0
380626-81-3
Ethyl 6-chloro-4-((2,4-dimethoxybenzyl)amino)nicotinate (15 g, 42.8 mmol) was used as a raw material, which was mixed with trifluoroacetic acid (TFA, 80 mL), heated to 50 °C and the reaction was maintained for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently removed under reduced pressure. The pH of the residue was adjusted to 8 with aqueous sodium bicarbonate (NaHCO3) and then extracted with ethyl acetate (EtOAc). The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Finally, the residue was purified by silica gel column chromatography (petroleum ether:ethyl acetate=4:1) to afford the target product ethyl 4-amino-6-chloronicotinate (5.1 g, 61% yield) as a white solid.
References
[1] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 218
[2] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 180-181
ethyl 4-amino-6-chloronicotinate Preparation Products And Raw materials
ethyl 4-amino-6-chloronicotinate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39021 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16512 | 58 |
View Lastest Price from ethyl 4-amino-6-chloronicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | ethyl 4-amino-6-chloronicotinate
380626-81-3
|
$1.00 | 1KG | 95%-99% | 1ton | Career Henan Chemical Co | |
 |
2020-01-09 | ethyl 4-amino-6-chloronicotinate
380626-81-3
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co |
-
- ethyl 4-amino-6-chloronicotinate
380626-81-3
- $1.00
- 95%-99%
- Career Henan Chemical Co
-
- ethyl 4-amino-6-chloronicotinate
380626-81-3
- $1.00
- 99%
- Career Henan Chemical Co
380626-81-3(ethyl 4-amino-6-chloronicotinate)Related Search:
1of3
