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ChemicalBook >> CAS DataBase List >>NELFINAVIR

NELFINAVIR

CAS No.
159989-64-7
Chemical Name:
NELFINAVIR
Synonyms
AG 1341;nefinavir;NELFINAVIR;NELFINAVIR-12;Nelfinavir D5;8a-beta))-a-bet;NELFINAVIR iMpurity;NELFINAVIR USP/EP/BP;Nelfinavir (AG-1341);Nelfinavir (AG-1343)
CBNumber:
CB8213806
Molecular Formula:
C32H45N3O4S
Molecular Weight:
567.78
MDL Number:
MFCD01938163
MOL File:
159989-64-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:49:32
Product description Number Pack Size Price
Nelfinavir 98.65% CS-0677 1mg $51
Nelfinavir 98.65% CS-0677 5mg $108
Nelfinavir 98.65% CS-0677 10mg $152
Nelfinavir 98.65% CS-0677 25mg $227
Nelfinavir 98.65% CS-0677 50mg $303
More product size

NELFINAVIR Properties

Melting point 185-186 °C
Boiling point 786.8±60.0 °C(Predicted)
alpha D -119.23° (c = 0.26 in methanol)
Density 1.22±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility ≥ 20.45mg/mL in Ethanol
form Powder
pka pKa1 6.0; pKa2 11.06(at 25℃)
color White to off-white
Water Solubility 7g/L(temperature not stated)
FDA UNII HO3OGH5D7I
ATC code J05AE04

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P501-P270-P264-P301+P312+P330
Toxicity rat,LD,oral,> 5gm/kg (5000mg/kg),Toxicologist. Vol. 42, Pg. 55, 1998.

NELFINAVIR price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0677 Nelfinavir 98.65% 159989-64-7 1mg $51 2026-06-04 Buy
ChemScene CS-0677 Nelfinavir 98.65% 159989-64-7 5mg $108 2026-06-04 Buy
ChemScene CS-0677 Nelfinavir 98.65% 159989-64-7 10mg $152 2026-06-04 Buy
ChemScene CS-0677 Nelfinavir 98.65% 159989-64-7 25mg $227 2026-06-04 Buy
ChemScene CS-0677 Nelfinavir 98.65% 159989-64-7 50mg $303 2026-06-04 Buy
Product number Packaging Price Buy
CS-0677 1mg $51 Buy
CS-0677 5mg $108 Buy
CS-0677 10mg $152 Buy
CS-0677 25mg $227 Buy
CS-0677 50mg $303 Buy

NELFINAVIR Chemical Properties,Uses,Production

Uses

Antiviral.

Definition

ChEBI: An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.

Indications

Nelfinavir (Viracept) is probably the most commonly used protease inhibitor because of its low incidence of serious adverse effects. Its most common side effects are diarrhea and flatulence; these may resolve with continued use. In addition to the drugs contraindicated for use with all protease inhibitors, amiodarone, rifampin, and quinidine are contraindicated in patients taking nelfinavir.

brand name

Viracept (Agouron).

Antimicrobial activity

Nelfinavir inhibits HIV-1 and HIV-2 proteases. Bioavailability is affected to only a limited degree by combination with lowdose ritonavir.

Acquired resistance

Resistance is most frequently selected through a D30N mutation in the HIV protease. An L90M mutation also confers resistance.

Pharmaceutical Applications

A synthetic chemical formulated as the mesylate for oral administration.

Pharmacokinetics

Oral absorption: c. 70–80% (with food)
Cmax 750 mg thrice daily: c. 3–4 mg/L
1250 mg twice daily: c. 4 mg/L
Cmin 750 mg thrice daily: c. 1–3 mg/L
1250 mg twice daily: c. 0.7–2.2 mg/L
Plasma half-life: c. 3.5 h
Volume of distribution: c. 2–7 L/kg
Plasma protein binding: >98%
Absorption and distribution
Food improves the bioavailability and the drug should be administered with a light meal. The semen:plasma ratio is 0.07. It is distributed into breast milk.
Metabolism and excretion
One major and several minor oxidative metabolites are found in plasma. Most of an oral dose is recovered in feces as unchanged drug (22%) and metabolites (78%). The remainder is recovered in urine, mainly unchanged.
An increase in the area under the time–concentration curve (AUC) has been observed in patients with hepatic impairment, but specific dose recommendations have not been made.

Clinical Use

Treatment of HIV infection (in combination with other antiretroviral drugs)

Side effects

The most common adverse effect is diarrhea of mild to moderate severity. Other side effects include nausea, fatigue, vomiting and headache. It is associated with less dyslipidemia in comparison with ritonavir-boosted protease inhibitors.

Metabolism

Following oral administration, nelfinavir peak levels in plasma ranged from 0.34 mg/mL (10 mg/kg in the dog) to 1.7 mg/mL (50 mg/kg in the rat). In the dog, nelfinavir was slowly absorbed, and bioavailability was 47%. The drug appeared to be metabolized in the liver, and the major excretory route was in feces.

NELFINAVIR Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 120)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49979 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30225 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 20584 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15073 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58

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View Lastest Price from NELFINAVIR manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NELFINAVIR pictures 2026-06-03 NELFINAVIR
159989-64-7
99% up, High Density 20 tons Sinoway Industrial co., ltd.
Nelfinavir pictures 2026-04-22 Nelfinavir
159989-64-7
$44.00 98.16% 10g TargetMol Chemicals Inc.
NELFINAVIR pictures 2025-12-01 NELFINAVIR
159989-64-7
1KG 98 10000KGS Shaanxi Dideu New Materials Co. Ltd
  • NELFINAVIR pictures
  • NELFINAVIR
    159989-64-7
  • 99% up, High Density
  • Sinoway Industrial co., ltd.
  • Nelfinavir pictures
  • Nelfinavir
    159989-64-7
  • $44.00
  • 98.16%
  • TargetMol Chemicals Inc.
  • NELFINAVIR pictures
  • NELFINAVIR
    159989-64-7
  • 98
  • Shaanxi Dideu New Materials Co. Ltd

NELFINAVIR Spectrum

3-isoquinolinecarboxamide,n-(1,1-dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hy 8a-beta))-a-bet nefinavir NELFINAVIR (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide Nelfinavir & Nelfinavir Mesylate AG 1341 NELFINAVIR-12 Nelfinavir Regeoisomer N-tert-butyl-2-[2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)-oxomethyl]amino]-4-(phenylthio)butyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide AG 1341; AG-1341; AG1341 3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)- NELFINAVIR USP/EP/BP (3S,4aS,8aS)-N-(tert-Butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide Nelfinavir (AG-1341) Nelfinavir D5 NELFINAVIR iMpurity Nelfinavir, 10 mM in DMSO Nelfinavir (AG-1343) 159989-64-7 C32H45N3O4SCH4O3S C32H45N3O4SC32H45N3O4SCH3SO3H peptides
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