Esculin
- CAS No.
- 531-75-9
- Chemical Name:
- Esculin
- Synonyms
- Esculine;ESCULIN;Escosyl;BICOLOIN;AESCULIN;POLYDROM;Bicolorin;Crataegin;Polychrom;vitaminc2
- CBNumber:
- CB8245061
- Molecular Formula:
- C15H16O9
- Molecular Weight:
- 340.28
- MDL Number:
- MFCD00006879
- MOL File:
- 531-75-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Esculin hydrate ≥98% | E8250 | 5g | $66.3 |
| Esculin European Pharmacopoeia (EP) Reference Standard | Y0001612 | 2 ea | $167 |
| Esculin hydrate ≥98.0%(HPLC) | 02350 | 10g | $95 |
| Esculin hydrate ≥98.0%(HPLC) | 02350 | 50g | $341 |
| Esculin hydrate analytical standard | 06212 | 100mg | $75.4 |
| More product size | |||
| Melting point | 203 °C |
|---|---|
| alpha | -88 º (c=2,dioxane/water1:1) |
| Boiling point | 396.1°C (rough estimate) |
| Density | 0.791 g/mL at 20 °C |
| vapor pressure | 0Pa at 25℃ |
| refractive index | -79 ° (C=2.4, 50% Dioxane) |
| Flash point | 15 °C |
| storage temp. | 2-8°C |
| solubility | methanol: 50 mg/mL hot, clear to very faintly turbid, yellow-green fluoresc. |
| form | Liquid |
| pka | 7.00±0.20(Predicted) |
| color | Clear |
| optical activity | [α]20/D 41±2°, c = 5% in pyridine |
| Water Solubility | MODERATELY SOLUBLE |
| Merck | 3698 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions |
TONIC LIGHT STABILIZER |
| InChI | 1S/C15H16O9.H2O/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17;/h1-4,10,12-17,19-21H,5H2;1H2/t10-,12-,13+,14-,15-;/m1./s1 |
| InChIKey | YRABYCJKUBFWQY-FHXAZYNBSA-N |
| SMILES | O.OC[C@H]1O[C@@H](Oc2cc3C=CC(=O)Oc3cc2O)[C@H](O)[C@@H](O)[C@@H]1O || O.OC[C@H]1O[C@@H](Oc2cc3C=CC(=O)Oc3cc2O)[C@H](O)[C@@H](O)[C@@H]1O |
| LogP | -1.307 (est) |
| CAS DataBase Reference | 531-75-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1Y1L18LQAF |
| NIST Chemistry Reference | 7-Hydroxy-2-oxo-2h-chromen-6-yl hexopyranoside(531-75-9) |
| EPA Substance Registry System | Esculin (531-75-9) |
| UNSPSC Code | 85151701 |
| NACRES | NA.83 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312+P330-P501 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | F,C,Xi |
| Risk Statements | 11-20/21/22-34-68/20/21/22-36/37/38 |
| Safety Statements | 26-36/37/39-45-24/25-36/37-16 |
| RIDADR | UN 2924 3/PG 2 |
| WGK Germany | 3 |
| RTECS | DJ3085000 |
| F | 3-10-23 |
| TSCA | TSCA listed |
| HS Code | 29389090 |
| Storage Class | 11 - Combustible Solids |
| REACH Registrations | Active |
Esculin price More Price(102)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E8250 | Esculin hydrate ≥98% | 531-75-9 | 5g | $66.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001612 | Esculin European Pharmacopoeia (EP) Reference Standard | 531-75-9 | 2 ea | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | 02350 | Esculin hydrate ≥98.0%(HPLC) | 531-75-9 | 10g | $95 | 2026-04-30 | Buy |
| Sigma-Aldrich | 02350 | Esculin hydrate ≥98.0%(HPLC) | 531-75-9 | 50g | $341 | 2026-04-30 | Buy |
| Sigma-Aldrich | 06212 | Esculin hydrate analytical standard | 531-75-9 | 100mg | $75.4 | 2022-05-15 | Buy |
Esculin Chemical Properties,Uses,Production
Description
Aesculin (also Esculin) is a glucoside compound, which occurs naturally in unprocessed seeds, leaves, bark, and flowers of horse chestnut. Aesculin is used for the identification of bacteria, for the treatment of hemorrhoids and venous peripheral diseases. In cosmetics, aesculin was found to be effective in the treatment of aging skin. Owing to its ultraviolet absorbing activity, aesculin is employed in tanning preparations. Aesculin can be also used as a substrate for the detection of ß-gluocosidase activity in polyacrylamide gels.
References
[1] Anna D. Orla-Jensen, About the application of aesculin for the identification of bacteria, APMIS, 1934, vol. 11, 312-322
[2] S. Srijayanta, A. Raman and B. L. Goodwin, A comparative study of the constituents of Aesculus hippocastanum and Aesculus indica, Journal of Medical Food, 1999, vol. 2, 45-50
[3] Ki-Sun Kwon, Jaehoon Lee, Hyung Gyoo Kang and Yung Chil Hah, Detection of ß-Glucosidase Activity in Polyacrylamide Gels with Esculin as Substrate, Appl. Environ. Microbil., 1994, vol. 80, 4584-4586
[4] Dennis J Mckenna, Kenneth Jones, Kerry Hughes and Virginia M Tyler, Botanical Medicines: The Desk Reference for Major Herbal Supplements, Second Edition, 2011
Chemical Properties
White to nearly white
Uses
Esculin hydrate has been used as a component of sporulation-inducing esculin agar. It has also been used for esculin uptake assay.
Uses
esculoside is utilized in formulations for the treatment of cellulite. es culoside is apparently beneficial for impaired microcirculation.
Uses
esculin is used as a skin protectant in ointments and creams. This is a glucoside compound originally obtained from the leaves and bark of the horse chestnut tree.
Definition
ChEBI: A hydroxycoumarin that is the 6-O-beta-D-glucoside of esculetin.
General Description
Esculin hydrate has vasoprotective and venotonic properties.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Esculin is a coumarin glycoside that demonstrates antioxidant activitites and protection against chemically-induced carcinogenesis. Esculin is utilized in microbiology for the isolation and identification of Enterococcus (group D streptococci).
Esculin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +86-18629295024 | qinhe02@xaltbio.com | China | 997 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 480 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Jinan Ruitong Biotech Co., Ltd. | +86-16615778970 +86-16615778970 | info@ritonbio.com | China | 511 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +86-18080483897 | sales@biopurify.com | China | 4616 | 58 |
View Lastest Price from Esculin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-29 | Aesculin
531-75-9
|
$100.00 | 1kg | 10-98% | 10000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2026-07-29 | Esculin | $10.00 | 1kg | 80% | 10000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2026-07-09 | Esculin
531-75-9
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd |
