ChemicalBook >> CAS DataBase List >>4-Chloro-3-(trifluoromethyl)phenyl isocyanate
4-Chloro-3-(trifluoromethyl)phenyl isocyanate
- CAS No.
- 327-78-6
- Chemical Name:
- 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
- Synonyms
- 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene;JC0002;Sorafenib INT1;Regorafenib Impurity 61;Sorafenib intermediate 3;Sorafenib related compound 36;2-nitro-4-chlorophenylaceticacid;4-Chloro-3-(trifluoromethyl)benzene;4-chloro-a,a,a-trifluoro-M-tolyl ester;4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate
- CBNumber:
- CB8262374
- Molecular Formula:
- C8H3ClF3NO
- Molecular Weight:
- 221.56
- MDL Number:
- MFCD00013874
- MOL File:
- 327-78-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-20 23:19:27
| Product description | Number | Pack Size | Price |
| 4-Chloro-3-(trifluoromethyl)phenyl isocyanate 98% | 374881 | 5g | $30.9 |
| 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >98.0%(GC) | C2778 | 5g | $56 |
| 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >98.0%(GC) | C2778 | 25g | $178 |
| 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Asreported | 267374 | 5g | $365 |
| 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Asreported | 267374 | 10g | $505 |
| More product size | |||
| Melting point | 40-42 °C(lit.) |
|---|---|
| Boiling point | 86-90 °C14 mm Hg(lit.) |
| Density | 1.4720 (estimate) |
| vapor pressure | 91Pa at 20℃ |
| Flash point | 211 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Chloroform, Methanol |
| form | Low Melting Solid, Powder or Chunks |
| color | White to yellow |
| Sensitive | Moisture Sensitive |
| BRN | 522032 |
| InChI | InChI=1S/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H |
| InChIKey | AHFPRSSHNSGRCU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=CC=C(N=C=O)C=C1C(F)(F)F |
| CAS DataBase Reference | 327-78-6(CAS DataBase Reference) |
| FDA UNII | 6TE36JKP7L |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H315-H317-H318-H334-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37-36/37/38-42-20/22 | |||||||||
| Safety Statements | 7-26-27-37/39-36/37/39-45-23 | |||||||||
| RIDADR | UN 2206 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful/Moisture Sensitive | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29291090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Dam. 1 Resp. Sens. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
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| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4-Chloro-3-(trifluoromethyl)phenyl isocyanate price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 374881 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate 98% | 327-78-6 | 5g | $30.9 | 2026-04-30 | Buy |
| TCI Chemical | C2778 | 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >98.0%(GC) | 327-78-6 | 5g | $56 | 2026-04-30 | Buy |
| TCI Chemical | C2778 | 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >98.0%(GC) | 327-78-6 | 25g | $178 | 2026-04-30 | Buy |
| Usbiological | 267374 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Asreported | 327-78-6 | 5g | $365 | 2026-06-03 | Buy |
| Usbiological | 267374 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Asreported | 327-78-6 | 10g | $505 | 2026-06-03 | Buy |
4-Chloro-3-(trifluoromethyl)phenyl isocyanate Chemical Properties,Uses,Production
Chemical Properties
White solid or melt
Uses
4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of:
- N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea
- [1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea]
- trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea
Uses
4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of: N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea [1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea] trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea
General Description
4-Chloro-3-(trifluoromethyl)phenyl isocyanate participates in an efficient methodology for the synthesis of 5-methyl-3-aryl-2-thiooxazolidin-4-ones.
Flammability and Explosibility
Non flammable
Synthesis of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate from Triphosgene and 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine
4-Chloro-3-(trifluoromethyl)phenyl isocyanate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 496)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 | info@senovatech.com | China | 351 | 58 |
| Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29094 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
View Lastest Price from 4-Chloro-3-(trifluoromethyl)phenyl isocyanate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
|
1kg | 99%min | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-21 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-07-09 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
|
$6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
- $0.00
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
- $6.00
- 99%
- Henan Fengda Chemical Co., Ltd
327-78-6(4-Chloro-3-(trifluoromethyl)phenyl isocyanate)Related Search:
Propyl isocyanate
4-Chlorobenzotrifluoride
4-(Chloromethyl)benzoic acid
3-Fluorobenzotrifluoride
Vinylbenzyl chloride
Phenyl butyrate
Chlorosulfonyl isocyanate
Diphenyl chlorophosphate
Phenyl isothiocyanate
PHENYL ACETATE
1of4
4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE
3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE
4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE 98%
4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate
4-Chloro-3-(trifluoromethyl)phenyl isocyanate,98%
4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 98% 5GR
Benzene, 1-chloro-4-isocyanato-2-(trifluoromethyl)-
4-chloro-a,a,a-trifluoro-M-tolyl ester
4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 97.5%
4-Chloro-3-(trifluoroMethoxy)phenyl Isocyanate
Three fluorine chlorine - 4-3 - Methyl phenyl isocyanate
Sorafenib INT1
Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester
4-CHLORO-3-TRIFLUROMETHYL)PHENYL ISOCYANATE
4-Chloro-3-(trifluoromethyl)phenyl isocyanate(327-78-6)
4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >
4-Chloro-3-(trifluoromethy) phenyl isocyanate
Phenyl 4- chloro -3- trifluoromethyl isocyanate
Sorafenib intermediate 3
2-nitro-4-chlorophenylaceticacid
JC0002
Regorafenib Impurity 61
4-Chloro-3-(trifluoromethyl)benzene
Sorafenib related compound 36
1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene
327-78-6
372-78-6
327-18-6
ClC6H3CF3NCO
ARYL ISOCYANATE
Building Blocks
Organic Building Blocks
Nitrogen Compounds
Isocyanates
Phenyl isocyanate&Phenyl isothiocyanate
Isocyanates
Nitrogen Compounds
Organic Building Blocks
