PF-562771
- CAS No.
- 834894-21-2
- Chemical Name:
- PF-562771
- Synonyms
- CS-882;AP 23848;PF-562771;3-[2-[2-Cyclopentyl-6-[[4-(dipropylphosphinyl)phenyl]amino]-9H-purin-9-yl]ethyl]phenol;Phenol, 3-[2-[2-cyclopentyl-6-[[4-(dipropylphosphinyl)phenyl]amino]-9H-purin-9-yl]ethyl]-;(4-((2-cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide
- CBNumber:
- CB82630771
- Molecular Formula:
- C30H38N5O2P
- Molecular Weight:
- 531.63
- MDL Number:
- MFCD24386808
- MOL File:
- 834894-21-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| AP23848 | JIB89421 | 25mg | $828.25 |
| AP23848 | JIB89421 | 50mg | $1325.5 |
| AP23848 | JIB89421 | 100mg | $1844 |
| AP23848 98+% | BD-A460885 | 100mg | $422 |
| AP23848 | CSN25318 | 10mg | $165 |
| Boiling point | 710.2±70.0 °C(Predicted) |
|---|---|
| Density | 1.28±0.1 g/cm3(Predicted) |
| pka | 9.93±0.10(Predicted) |
| FDA UNII | 8PAK5CI13U |
PF-562771 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | JIB89421 | AP23848 | 834894-21-2 | 25mg | $828.25 | 2026-06-04 | Buy |
| Biosynth | JIB89421 | AP23848 | 834894-21-2 | 50mg | $1325.5 | 2026-06-04 | Buy |
| Biosynth | JIB89421 | AP23848 | 834894-21-2 | 100mg | $1844 | 2026-06-04 | Buy |
| Arctom | BD-A460885 | AP23848 98+% | 834894-21-2 | 100mg | $422 | 2026-05-26 | Buy |
| CSNpharm | CSN25318 | AP23848 | 834894-21-2 | 10mg | $165 | 2021-12-16 | Buy |
PF-562771 Chemical Properties,Uses,Production
Uses
AP23848 is an ATP-dependent kinase inhibitor that effectively and selectively targets the Kit activation loop mutation both in vitro and in vivo, showing anti-tumor activity. AP23848 can inhibit the phosphorylation of the activated Kit mutation and tumor growth in mice, making it suitable for targeting diseases with the D816V mutation, such as systemic mastocytosis (SM) and acute myeloid leukemia (AML) research[1].
References
[1] Amie S Corbin, et al. In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit. Blood. 2005 Jul 1;106(1):227-34. DOI:10.1182/blood-2004-12-4771
PF-562771 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-562771 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9945 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9976 | 60 |
| Nanjing Norris-Pharm Technology Co., Ltd | 18652989687 | sales@norris-pharm.com | China | 8878 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4784 | 55 |
| GIHI CHEMICALS CO.,LTD | 0086-571-86217390 | Sales@gihichem.com | China | 860 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7750 | 56 |
