4-Cyano-2-methylbenzoic acid
- CAS No.
- 1975-53-7
- Chemical Name:
- 4-Cyano-2-methylbenzoic acid
- Synonyms
- 4-Cyano-2-methylbenzoic acid;Benzoic acid, 4-cyano-2-methyl-
- CBNumber:
- CB82738352
- Molecular Formula:
- C9H7NO2
- Molecular Weight:
- 161.16
- MDL Number:
- MFCD14582960
- MOL File:
- 1975-53-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Cyano-2-methylbenzoic acid | BAA97553 | 10g | $375 |
| 4-Cyano-2-methylbenzoic acid | BAA97553 | 100g | $2500 |
| 4-Cyano-2-methylbenzoic acid 98% | OR960287 | 1g | $22 |
| 4-Cyano-2-methylbenzoic acid 98% | OR960287 | 5g | $86 |
| 4-Cyano-2-methylbenzoic acid 98% | OR960287 | 10g | $145 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2926907090 |
4-Cyano-2-methylbenzoic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BAA97553 | 4-Cyano-2-methylbenzoic acid | 1975-53-7 | 10g | $375 | 2026-06-04 | Buy |
| Biosynth | BAA97553 | 4-Cyano-2-methylbenzoic acid | 1975-53-7 | 100g | $2500 | 2026-06-04 | Buy |
| Apolloscientific | OR960287 | 4-Cyano-2-methylbenzoic acid 98% | 1975-53-7 | 1g | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR960287 | 4-Cyano-2-methylbenzoic acid 98% | 1975-53-7 | 5g | $86 | 2026-06-04 | Buy |
| Apolloscientific | OR960287 | 4-Cyano-2-methylbenzoic acid 98% | 1975-53-7 | 10g | $145 | 2026-06-04 | Buy |
4-Cyano-2-methylbenzoic acid Chemical Properties,Uses,Production
Synthesis
103261-67-2
1975-53-7
1. Hydrolysis reaction: Methyl 4-cyano-2-methylbenzoate (38g, 0.217mol) was dissolved in ethanol (450ml), aqueous sodium hydroxide (150ml, 2.9M) was added slowly, and the reaction was stirred for 12 hours at room temperature. After completion of the reaction, most of the ethanol was removed by distillation under reduced pressure. The residue was diluted with distilled water (300 ml) and the aqueous layer was washed with ether (200 ml x 2) to remove organic impurities. Subsequently, the aqueous layer was acidified with hydrochloric acid (450 ml, 1 M) to pH < 6 at 0 °C. The acidified mixture was extracted with ethyl acetate (400 ml × 3), the organic layers were combined, washed with saturated brine, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to give 4-cyano-2-methylbenzoic acid (40 g, 100% yield), the product was a yellow solid. 2. Acetylation reaction: 4-cyano-2-methylbenzoic acid (20g, 0.124mol) was dissolved in toluene (200ml), thionyl chloride (18ml, 0.248mol) and catalytic amount of dimethylformamide (0.5ml) were added. The mixture was stirred at 70°C for 14 hours. At the end of the reaction, the solvent and excess reagents were evaporated under reduced pressure to give 4-cyano-2-methylbenzoyl chloride (24 g, 100% yield), which was used directly in the subsequent reaction without further purification.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 12, p. 3671 - 3675
[2] Patent: WO2010/127926, 2010, A1. Location in patent: Page/Page column 46-47
[3] Patent: WO2009/77197, 2009, A1. Location in patent: Page/Page column 35-36
[4] Patent: WO2010/127928, 2010, A1. Location in patent: Page/Page column 32
[5] Patent: EP2272835, 2011, A1. Location in patent: Page/Page column 14-15
4-Cyano-2-methylbenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9300 | 58 |
