ANTI-PAR-4 (PROSTATE APOPTOSIS RESPONSE-4) RABBIT
- CAS No.
- Chemical Name:
- ANTI-PAR-4 (PROSTATE APOPTOSIS RESPONSE-4) RABBIT
- Synonyms
- ANTI-PAR-4 (PROSTATE APOPTOSIS RESPONSE-4) RABBIT;Anti-Par-4 (Prostate Apoptosis Response-4) antibody produced in rabbit
- CBNumber:
- CB8274593
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03791926
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| Anti-Par-4 (Prostate Apoptosis Response-4) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | P5367 | 200μL | $599 |
ANTI-PAR-4 (PROSTATE APOPTOSIS RESPONSE-4) RABBIT price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P5367 | Anti-Par-4 (Prostate Apoptosis Response-4) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 200μL | $599 | 2026-04-30 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| P5367 | 200μL | $599 | Buy |
ANTI-PAR-4 (PROSTATE APOPTOSIS RESPONSE-4) RABBIT Chemical Properties,Uses,Production
Uses
Anti-Par-4 (Prostate Apoptosis Response-4) antibody produced in rabbit may be used in immunoblotting.
General Description
PRKC apoptosis WT1 regulator protein (PAWR) is also known as prostate apoptosis response 4 protein (Par-4). The PAWR gene is mapped to human chromosome 12q21.2. It is a 40 kDa protein expressed ubiquitously in mammals. It was first identified in prostate tumors.It has a leucine zipper domain and nuclear localization sequences. A core domain comprising of region 137-195 amino acids is critical for the apoptotic function of PAR-4. It interacts and modulates the activity of protein kinase C.
Biochem/physiol Actions
Par-4 protein interacts with Wilm′s tumor suppressor WT1 and modulates its transcription and growth suppression function. The gene for Par-4 is down-regulated by oncogenic Ras via the Raf-1- mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK-ERK) pathway in immortalized fibroblasts. Overexpression of the PAR4 gene causes down-regulation of B-cell lymphoma-2 (Bcl-2) in fibroblasts and prostate cancer cells. Par-4 protein plays an important role in neuronal apoptosis. This gene is upregulated in neuronal degeneration and is observed in Alzheimer′s disease.
ANTI-PAR-4 (PROSTATE APOPTOSIS RESPONSE-4) RABBIT Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-PAR-4 (PROSTATE APOPTOSIS RESPONSE-4) RABBIT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6394 | 58 |
| Supplier | Advantage |
|---|---|
| Merck KGaA | 58 |
