Camostat mesilate
- CAS No.
- 59721-29-8
- Chemical Name:
- Camostat mesilate
- Synonyms
- CAMOSTAT MESYLATE;Foipan;CS-129;FOY-S 980;Foipan mesylate;Camostat (FOY305;CAMOSTAT MESILATE;Camostatemesylate;Camostate mesilate;Camosetam mesylate
- CBNumber:
- CB8299877
- Molecular Formula:
- C21H26N4O8S
- Molecular Weight:
- 494.52
- MDL Number:
- MFCD00941410
- MOL File:
- 59721-29-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Camostat mesylate ≥98% (HPLC) | SML0057 | 10mg | $75.2 |
| Camostat mesylate ≥98% (HPLC) | SML0057 | 50mg | $286 |
| Camostat Mesylate >98.0%(HPLC) | C2977 | 25mg | $75 |
| Camostat Mesylate >98.0%(HPLC) | C2977 | 100mg | $223 |
| Camostat (mesylate) ≥98% | 16018 | 5mg | $36 |
| More product size | |||
| Melting point | 150-1550C |
|---|---|
| RTECS | CY1571620 |
| storage temp. | 2-8°C |
| solubility | H2O: ≥24mg/mL |
| form | powder |
| color | white to tan |
| Water Solubility | Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml). |
| Merck | 14,1728 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| InChIKey | FSEKIHNIDBATFG-UHFFFAOYSA-N |
| SMILES | CS(O)(=O)=O.CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(N)=N)cc2)cc1 |
| CAS DataBase Reference | 59721-29-8(CAS DataBase Reference) |
| FDA UNII | 451M50A1EQ |
| UNSPSC Code | 12352203 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H400 | |||||||||
| Precautionary statements | P273-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-50 | |||||||||
| Safety Statements | 26-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 9 | |||||||||
| HS Code | 2934999090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Acute 1 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Camostat mesilate price More Price(100)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0057 | Camostat mesylate ≥98% (HPLC) | 59721-29-8 | 10mg | $75.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0057 | Camostat mesylate ≥98% (HPLC) | 59721-29-8 | 50mg | $286 | 2026-04-30 | Buy |
| TCI Chemical | C2977 | Camostat Mesylate >98.0%(HPLC) | 59721-29-8 | 25mg | $75 | 2026-04-30 | Buy |
| TCI Chemical | C2977 | Camostat Mesylate >98.0%(HPLC) | 59721-29-8 | 100mg | $223 | 2026-04-30 | Buy |
| Cayman Chemical | 16018 | Camostat (mesylate) ≥98% | 59721-29-8 | 5mg | $36 | 2026-04-30 | Buy |
Camostat mesilate Chemical Properties,Uses,Production
Description
Camostat mesylate is a broad spectrum protease inhibitor useful in the treatment of chronic pancreatitis.
Chemical Properties
Crystalline Solid
Originator
Ono (Japan)
Uses
Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor
Uses
It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.
Definition
ChEBI: Camostat mesylate is a methanesulfonate (mesylate) salt prepared from equimolar amounts of camostat and methanesulfonic acid. It is a serine protease inhibitor approved and marketed in Japan in 1985 for the alleviation of acute symptoms associated with chronic pancreatitis. In 1994, it was approved for the treatment of postoperative reflux esophagitis. It has a role as an anticoronaviral agent, an anti-inflammatory agent, an antifibrinolytic drug, an antihypertensive agent, an antineoplastic agent, an antiviral agent and a serine protease inhibitor. It contains a camostat(1+).
brand name
FOIPAN
Biological Activity
Orally active protease inhibitor. Known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration.
storage
Desiccate at RT
Background
Camostat Mesylate, also known as Foipan or FOY 305, is a synthetic serine protease inhibitor that is often used to treat pancreatitis pain. Camostat Mesylate attenuates airway epithelial sodium channel function by inhibiting channel-activating proteases with an IC50 of 50 nM. Camostat Mesylate inhibition of trypsin decreased food intake, body weight, blood glucose, liver weight, and lipidosis and increased FGF21 expression in obese mice.Camostat Mesylate is an effective inhibitor of TMPRSS2, a serine protease used by SARS-CoV-2/COVID-19 for viral S-protein priming and cell entry. Pre-treatment of human lung cancer cells with 100 μM Camostat Mesylate significantly reduced COVID-19 viral entry.
References
[1] JUNYA GIBO. Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity[J]. Laboratory Investigation, 2004, 85 1: 75-89. DOI:10.1038/labinvest.3700203
[2] KAMAL ALBARAZANJI. Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2019, 316 5: G653-G667. DOI:10.1152/ajpgi.00404.2018
[3] MIKI UEDA. The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.[J]. Nephron, 2015, 129 3: 223-232. DOI:10.1159/000375308
[4] MUTSUO YAMAYA . The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells[J]. Pulmonary pharmacology & therapeutics, 2015, 33: Pages 66-74. DOI:10.1016/j.pupt.2015.07.001
[5] MARKUS HOFFMANN. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.[J]. Cell, 2020: 271-280.e8. DOI:10.1016/j.cell.2020.02.052
Camostat mesilate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5983 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 | yklbiotech@163.com | CHINA | 296 | 58 |
View Lastest Price from Camostat mesilate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | Camostat mesilate
59721-29-8
|
1g | 99.5% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-03-20 | Camostat mesilate
59721-29-8
|
$10.00 | 1kg | 99% | 100ton | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-25 | Camostat mesilate
59721-29-8
|
$1.00-8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- Camostat mesilate
59721-29-8
- 99.5%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Camostat mesilate
59721-29-8
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Camostat mesilate
59721-29-8
- $1.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
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