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ChemicalBook >> CAS DataBase List >>3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one

3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one

CAS No.
1378390-29-4
Chemical Name:
3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one
Synonyms
Velpatasvir Intermediate 7;3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)...;3-(2-Bromoacetyl)-10,11-dihydro-5h-dibenzo[c,g]chromen-8(9h)-on;3-(2-Bromo-acetyl)-10,11-dihydro-5H,9H-6-oxa-benzo[a]anthracen-8-one;3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one;5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one, 3-(2-bromoacetyl)-10,11-dihydro-;3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one
CBNumber:
CB83044304
Molecular Formula:
C19H15BrO3
Molecular Weight:
371.22
MDL Number:
MFCD30187855
MOL File:
1378390-29-4.mol
MSDS File:
SDS
Last updated:2026-05-28 04:14:03
Product description Number Pack Size Price
3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one DFC39029 5g $900
3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one DFC39029 2g $900
3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one DFC39029 1g $900
3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one DFC39029 0.5g $900
3-(2-Bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one 97% B59368 100mg $42
More product size

3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one Properties

Boiling point 578.6±50.0 °C(Predicted)
Density 1.514±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
Appearance Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310

3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth DFC39029 3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 1378390-29-4 5g $900 2026-06-04 Buy
Biosynth DFC39029 3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 1378390-29-4 2g $900 2026-06-04 Buy
Biosynth DFC39029 3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 1378390-29-4 1g $900 2026-06-04 Buy
Biosynth DFC39029 3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 1378390-29-4 0.5g $900 2026-06-04 Buy
Synthonix B59368 3-(2-Bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one 97% 1378390-29-4 100mg $42 2026-05-06 Buy
Product number Packaging Price Buy
DFC39029 5g $900 Buy
DFC39029 2g $900 Buy
DFC39029 1g $900 Buy
DFC39029 0.5g $900 Buy
B59368 100mg $42 Buy

3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one Chemical Properties,Uses,Production

Uses

3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one is an antiviral agent and Velpatasvir (V116000) intermediate. Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.

Synthesis

3-vinyl-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

1378391-36-6

3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one

1378390-29-4

3-Vinyl-10,11-dihydro-5H-dibenzo[c,g]benzopyran-8(9H)-one (9.98 g, 36.1 mmol) was used as a starting material, which was dissolved in a stirred solvent mixture of THF (70 mL), DMSO (70 mL) and H2O (35 mL). N-bromosuccinimide (NBS, 6.75 g, 37.9 mmol) was added at once and the reaction mixture was stirred at room temperature for 33 min. After completion of the reaction, the reaction solution was diluted with ethyl acetate (EtOAc) and washed sequentially with water twice and brine once. The organic phase was dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude bromohydrin obtained was suspended in dichloromethane (DCM, 200 mL) and activated manganese dioxide (MnO2, 62.7 g, 722 mmol) was added. After stirring for 15 h at room temperature, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed several times with DCM. The combined filtrates (~400 mL) were treated with methanol (MeOH, ~100 mL) and the mixture was gradually concentrated under reduced pressure to allow the solids to precipitate out of solution. When the volume of liquid was reduced to about 200 mL, the solid was collected by filtration and washed with MeOH. The concentration, precipitation, filtration, and rinsing processes were repeated more than twice, resulting in three batches of 3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one in powder form (total 7.49 g, 56% two-step yield).

References

[1] Patent: WO2013/75029, 2013, A1. Location in patent: Page/Page column 140; 141; 142
[2] Patent: US2013/309196, 2013, A1. Location in patent: Paragraph 0366
[3] Patent: US2014/178336, 2014, A1
[4] Patent: US2015/361073, 2015, A1

3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one Preparation Products And Raw materials

Global( 66)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Hangzhou Cyanochem Co., Ltd. 		+86 17788583750 sales@cyanochem.com CHINA 281 58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		21-38751876 +8615000076078 info@rochipharma.com China 505 58
AFINE CHEMICALS LIMITED 		+86-571-85134551 info@afinechem.com China 15083 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9067 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52704 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49962 58

View Lastest Price from 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one pictures 2021-07-13 3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one
1378390-29-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one pictures 2021-07-10 3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one
1378390-29-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one pictures 2019-07-06 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one
1378390-29-4
 $100.00 1KG 98% 100KG Career Henan Chemical Co

3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one Spectrum

3-(2-Bromo-acetyl)-10,11-dihydro-5H,9H-6-oxa-benzo[a]anthracen-8-one 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one 3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 3-(2-Bromoacetyl)-10,11-dihydro-5h-dibenzo[c,g]chromen-8(9h)-on 3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)... 5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one, 3-(2-bromoacetyl)-10,11-dihydro- Velpatasvir Intermediate 7 1378390-29-4
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