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ChemicalBook >> CAS DataBase List >>4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride

4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride

CAS No.
55084-66-7
Chemical Name:
4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride
Synonyms
RSYY(Apremilast)-37;9H-FLUORENE-2,9-DICARBOXYLICACID;4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride;4-chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride;5-Pyrimidinecarbonyl chloride, 4-chloro-2-(methylthio)-;4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 95%;4-chloro-2-methylsulfanylpyrimidine-5-carboxylicacid,chloride;4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride
CBNumber:
CB83092835
Molecular Formula:
C6H4Cl2N2OS
Molecular Weight:
223.08
MDL Number:
MFCD12545984
MOL File:
55084-66-7.mol
MSDS File:
SDS
Last updated:2026-05-28 04:52:56
Product description Number Pack Size Price
4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% OR55187 250mg $24
4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% OR55187 1g $45
4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% OR55187 5g $154
4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% OR55187 10g $268
4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% OR55187 25g $515

4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride Properties

Boiling point 326.3±22.0 °C(Predicted)
Density 1.56±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
pka -2.80±0.29(Predicted)
InChI InChI=1S/C6H4Cl2N2OS/c1-12-6-9-2-3(5(8)11)4(7)10-6/h2H,1H3
InChIKey NMFCRGDGVPCDHH-UHFFFAOYSA-N
SMILES C(Cl)(C1=CN=C(SC)N=C1Cl)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P305+P351+P338-P310
HS Code  2933599590

4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR55187 4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% 55084-66-7 250mg $24 2026-06-04 Buy
Apolloscientific OR55187 4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% 55084-66-7 1g $45 2026-06-04 Buy
Apolloscientific OR55187 4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% 55084-66-7 5g $154 2026-06-04 Buy
Apolloscientific OR55187 4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% 55084-66-7 10g $268 2026-06-04 Buy
Apolloscientific OR55187 4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 98% 55084-66-7 25g $515 2026-06-04 Buy
Product number Packaging Price Buy
OR55187 250mg $24 Buy
OR55187 1g $45 Buy
OR55187 5g $154 Buy
OR55187 10g $268 Buy
OR55187 25g $515 Buy

4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride Chemical Properties,Uses,Production

Synthesis

4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid

397308-78-0

4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride

55084-66-7

General procedure for the synthesis of 4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride from 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid: first, a suspension of potassium trimethylmethylsilanesulfonate (90% industrial, 40 g, 0.31 mol) in 1,2-dimethoxyethane (300 mL) was slowly added over a 20-minute period to a 4-chloro-2-(methylthio)-5- pyrimidine carboxylic acid ethyl ester (Aldrich, 15 g, 64 mmol) in a solution of 1,2-dimethoxyethane (100 mL). A mild exotherm was observed during the addition and an ice bath was used to maintain the reaction system at ambient temperature. After the addition was completed, the resulting suspension was stirred at ambient temperature for 1 hour, followed by heating and refluxing for 36 hours, after which it was cooled to ambient temperature. The reaction mixture was quenched with 1 M aqueous hydrochloric acid and then extracted with ethyl acetate and the organic phase was dried over sodium sulfate to give the crude product (11 g). The crude product was recrystallized in ethyl acetate to give 4-hydroxy-2-methylthiopyrimidine-5-carboxylic acid as a white solid (8.8 g, 47 mmol, 73% yield). Mass spectrum (-ESI) m/z 185 (M-, 100). A portion of the product (3.00 g, 16.1 mmol) was mixed with thionyl chloride (90 mL), catalyzed by the addition of DMF (0.20 mL), and the mixture was heated to reflux. After refluxing for 1 hour, it was cooled to ambient temperature and concentrated in vacuum to give a beige solid. The solid was successively ground with hot toluene and hot hexane (the soluble portion was the target product), and vacuum concentration gave 4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride as a white solid (3.90 g, 15.6 mmol, 97% yield).1H NMR (300 MHz, CDCl3) δ 9.15 (s, 1H), 2.63 (s, 3H).

References

[1] Patent: US7176310, 2007, B1. Location in patent: Page/Page column 48
[2] Patent: US2014/275023, 2014, A1. Location in patent: Paragraph 0290; 0291
[3] Patent: WO2015/61247, 2015, A2. Location in patent: Paragraph 00618

4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride Preparation Products And Raw materials

4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride Suppliers

Global( 51)Suppliers
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Fuxin Pharmaceutical
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SHANGHAI T&W PHARMACEUTICAL CO., LTD.
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CR Corporation Limited
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HANGZHOU LEAP CHEM CO., LTD.
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TAIZHOU DKD CHEMICAL CO., LTD.
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Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
+8613601750004 lizhi@pharoschem.com China 439 58
Aceschem Inc.
+1-817863-6948 +1-(817)863-6948 sales@aceschem.com United States 19632 58
Changzhou AniKare Pharmatech Co., Ltd.
+86-0519-8359-8696 +8618018249389 sales@anikare.com China 9969 58

View Lastest Price from 4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
	4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride pictures 2023-12-04 4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride
55084-66-7
98% 100kg Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride pictures 2022-11-17 4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride
55084-66-7
25kg 99% 20 tons TAIZHOU DKD CHEMICAL CO., LTD.
4-Chloro-2-methylmercaptopyrimidine-5-carboxylic acid chloride 4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride 5-Pyrimidinecarbonyl chloride, 4-chloro-2-(methylthio)- 4-chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride 95% 4-chloro-2-methylsulfanylpyrimidine-5-carboxylicacid,chloride 9H-FLUORENE-2,9-DICARBOXYLICACID RSYY(Apremilast)-37 55084-66-7
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