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ChemicalBook >> CAS DataBase List >>Adenosine Deaminase

Adenosine Deaminase

CAS No.
9026-93-1
Chemical Name:
Adenosine Deaminase
Synonyms
ADENOSINE DEAMINASE;C:C&B7;EC 3.5.4.4;ADENOSINE DEMINASE;deaminase,adenosine;EC 3.5.4.4 USP/EP/BP;Adenosine Deaminase ADA;Retinol Binding Protcin;Deoxyadenosine deaminase;AdenosinedeaMinaseTypeII
CBNumber:
CB8351045
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD00081287
MOL File:
Mol file
MSDS File:
SDS
Last updated:2026-01-15 09:22:00
Product description Number Pack Size Price
Adenosine Deaminase from bovine spleen Type IX, ammonium sulfate suspension, 150-200?units/mg protein A5168 250units $553
Adenosine Deaminase from bovine spleen Type IX, ammonium sulfate suspension, 150-200?units/mg protein A5168 1000units $1880
Adenosine Deaminase from bovine spleen Type X, buffered aqueous glycerol solution, ≥130?units/mg protein A5043 250units $549
Adenosine Deaminase from bovine spleen Type X, buffered aqueous glycerol solution, ≥130?units/mg protein A5043 1000units $1770
Adenosine Deaminase PurifiedbyProteinGaffinitychromatography. 553929 50ug $509
More product size

Adenosine Deaminase Properties

storage temp. 2-8°C
solubility Buffered aqueous glycerol solution
form solution (clear)
color pale yellow
biological source bovine spleen
Water Solubility water: miscible
Specific Activity 150-200units/mg protein
FDA UNII XPQ5L1L4WO
UNSPSC Code 12352204
NACRES NA.54

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Safety Statements  23-24/25
WGK Germany  3
F  10
HS Code  35079090
Storage Class 10 - Combustible liquids

Adenosine Deaminase price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A5168 Adenosine Deaminase from bovine spleen Type IX, ammonium sulfate suspension, 150-200?units/mg protein 9026-93-1 250units $553 2026-04-30 Buy
Sigma-Aldrich A5168 Adenosine Deaminase from bovine spleen Type IX, ammonium sulfate suspension, 150-200?units/mg protein 9026-93-1 1000units $1880 2026-04-30 Buy
Sigma-Aldrich A5043 Adenosine Deaminase from bovine spleen Type X, buffered aqueous glycerol solution, ≥130?units/mg protein 9026-93-1 250units $549 2026-04-30 Buy
Sigma-Aldrich A5043 Adenosine Deaminase from bovine spleen Type X, buffered aqueous glycerol solution, ≥130?units/mg protein 9026-93-1 1000units $1770 2026-04-30 Buy
Usbiological 553929 Adenosine Deaminase PurifiedbyProteinGaffinitychromatography. 50ug $509 2026-06-03 Buy
Product number Packaging Price Buy
A5168 250units $553 Buy
A5168 1000units $1880 Buy
A5043 250units $549 Buy
A5043 1000units $1770 Buy
553929 50ug $509 Buy

Adenosine Deaminase Chemical Properties,Uses,Production

Description

Adenosine deaminase (ADA) is a purine catabolic enzyme ubiquitous in mammalian tissue which catalyzes deamination of both adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine respectively. ADA is a class of nucleoside catabolic enzymes with significant links to the body's cellular immune system, comprising a group of thiol-containing hydrolases. ADA plays a pivotal role in purine nucleotide catabolism, catalysing the degradation of adenosine nucleosides into inosine nucleosides. These inosine nucleosides are subsequently phosphorylated by nucleoside phosphorylase into inosine, which is ultimately oxidised into the metabolic product uric acid.
Adenosine deaminase
ADA is widely distributed throughout the body, with the highest levels found in the thymus, spleen, and other lymphoid tissues. It is also present in the liver, kidneys, skeletal muscle, and lungs. In peripheral blood, lymphocytes and monocytes show the highest enzymatic activity. The activity in red blood cells and granulocytes is 40–70 times greater than that in serum, with T lymphocytes exhibiting higher activity than B lymphocytes.
Gel electrophoresis can distinguish between the ADA1, ADA2, and ADA2?1 subtypes, whose phenotypes are controlled by the ADA1 and ADA2 alleles on chromosome 20. Typing can generally be performed using three-month-old blood spots. Among the Han Chinese population in China, ADA1 accounts for about 95% of cases, while among ethnic minorities it constitutes approximately 84%. The ability to distinguish individual ADA subtypes remains relatively limited.

Chemical Properties

White amorphous powder

Uses

Adenosine deaminase has been used to pre-treat primary Kupffer cells.

Uses

Adenosine deaminase is useful in various molecular biology assays, such as glycerol release assays . Adenosine deaminase is a potential target for treatments of combined immunodeficiency disease.

Biological Functions

Adenosine deaminase(EC 3.5.4.4), found in a wide variety of microorganisms, plants, invertebrates, and animals, plays a role in purine metabolism.

General Description

Molecular weight: 32.5-33 kDa

pI: 4.85

Biochem/physiol Actions

Adenosine deaminase is a purine catabolic enzyme which catalyzes the deamination of adenosine and 2′-deoxyadenosine with approximately equal specificity. It is ubiquitous in mammalian tissue, and deficiency in adenosine deaminase has been associated with severe combined immunodeficiency disease.

References

[1] KURATA N. [Adenosine deaminase].[J]. Nihon rinsho. Japanese journal of clinical medicine, 1995, 53 5: 1178-1183. 
[2] N. SPENCER   HARRY H  D A HOPKINSON. Adenosine deaminase polymorphism in man[J]. Annals of Human Genetics, 1968, 32 1: 9-14. DOI:10.1111/j.1469-1809.1968.tb00044.x. 
[3] D A CARSON   J E S  J Kaye. Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).[J]. Proceedings of the National Academy of Sciences of the United States of America, 1977, 74 12: 5677-5681. DOI:10.1073/pnas.74.12.5677. 
[4] QIU-LI LIANG. Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: A meta-analysis[J]. Respiratory medicine, 2008, 102 5: Pages 744-754. DOI:10.1016/j.rmed.2007.12.007. 
[5] J. UNGERER. Serum adenosine deaminase: isoenzymes and diagnostic application.[J]. Clinical chemistry, 1992, 99 1: 1322-1326. DOI:10.1093/CLINCHEM/38.7.1322. 
[6] LIQIAO HAN . Optimization of an enzyme-coupling method by spectrophotometer for serum adenosine deaminase: As a candidate reference method[J]. Analytical biochemistry, 2019, 587: Article 113462. DOI:10.1016/j.ab.2019.113462.

Adenosine Deaminase Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 209)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Creative Enzymes 		1-516-855-7709 info@creative-enzymes.com United States 8748 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Hubei Xindesheng Material Technology Co., Ltd. 		+8618971041571 vickyzhao@whdschem.com China 174 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29093 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5995 58

Related Qustion

Ask a question
Q:What is the function and mechanism of Adenosine aminohydrolase(EC 3.5.4.4)?Zora - Dec 11，2025
A:Adenosine aminohydrolase(EC 3.5.4.4) is a purine catabolic enzyme ubiquitous in mammalian tissue which catalyzes deamination of both adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine respectively. The proposed mechanism for adenosine deaminase (ADA)-catalyzed deamination is stereospecific addition-elimination via tetrahedral intermediate. By either mechanism, Zn2+ as a strong electrophile activates a water molecule, which is deprotonated by the basic Asp295 to form the attacking hydroxide. His238 orients the water molecule and stabilizes the charge of the attacking hydroxide. Glu217 is protonated to donate a proton to N1 of the substrate.

View Lastest Price from Adenosine Deaminase manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Adenosine Deaminase pictures 2026-07-27 Adenosine Deaminase
9026-93-1
 1g 98.0% 1kg/month WUHAN FORTUNA CHEMICAL CO., LTD
adenosine deaminase pictures 2023-08-03 adenosine deaminase
9026-93-1
 $62.70-68.50 10KU ≥ 10U/mg 1000ku Hubei Xindesheng Material Technology Co., Ltd.
EC 3.5.4.4 pictures 2019-07-06 EC 3.5.4.4
9026-93-1
 $2.00 1kg 99% 100kg Career Henan Chemical Co
  • adenosine deaminase pictures
  • adenosine deaminase
    9026-93-1
  • $62.70-68.50
  • ≥ 10U/mg
  • Hubei Xindesheng Material Technology Co., Ltd.
  • EC 3.5.4.4 pictures
  • EC 3.5.4.4
    9026-93-1
  • $2.00
  • 99%
  • Career Henan Chemical Co
fromcalfintestinalmucosabiochemika,in50%glycerol,0.01mkh2po4,ph6.0solution(clear),pal Adenosinedeaminasebovinespleen adenosine deaminase from bovine spleen ADENOSINE DEAMINASE, FROM CALF SPLEEN Deoxyadenosine deaminase Adenosine deaminase [>=150 units/mg] AdenosinedeaMinaseTypeII Adenosine deaminase, lyophil. Adenosine deaminase bovine, recombinant Adenosine deaminase human Adenosine deaminase chicken, recombinant Adenosine deaminase Streptococcus thermophilus, recombinant Adenosine Deaminase ADA Adenosine deaMinase froM calf spleen 15U/Mg ADENOSINE DEAMINASE, BOVINE INTESTINE ADENOSINE DEAMINASE TYPE IX ADENOSINE DEAMINASE TYPE V ADENOSINE DEAMINASE TYPE VIII ADENOSINE DEAMINASE TYPE X ADENOSINE AMINOHYDROLASE ADENOSINE AMINOHYDROLASE TYPE IX ADENOSINE AMINOHYDROLASE TYPE V ADENOSINE AMINOHYDROLASE TYPE X ADENOSINE DEAMINASE TYPE X FROM CALFSPLE EN ADENOSINE DEAMINASE TYPE VIIIFROM CALF I NTESTINAL ADENOSINE DEAMINASE TYPE IX FROM CALFSPL EEN ADENOSINE DEAMINASE TYPE V FROM BOVINE S ADENOSINE DEAMINASE F. CALF INTESTINAL M UCOSA, ~160 U/MG ADENOSINE DEAMINASE TYPE VIFROM CALF INT ESTINAL MU ADENOSINE DEAMINASE TYPE II CRUDE POWDER EC 3.5.4.4 HUMAN ADENOSINE DEAMINASE Adenosine deaminase from calf intestinal mucosa Adenosine deaminase from calf intestinal mucosa;ADA deaminase,adenosine EC 3.5.4.4 Adenosine Deaminase, 200U/mg Adenosine deaminase, Recombinant Adenosine deaminase from Human, Recombinant Native Calf Adenosine Deaminase C:C&B7 EC 3.5.4.4 USP/EP/BP ADENOSINE DEAMINASE EC 3.5.4.4 Adenosine Deaminase Retinol Binding Protcin Adenosine aminohydrolase(ADA) ADENOSINE DEMINASE Adenosine Deaminase Screening Kit Adenosine deaminase, type X, buffered aqueous glycerol solution Adenosine deaminase, type X, buffered aqueous glycerol solution, >130units/mg Adenosine Deaminase Activity Microplate Assay Kit Adenosylhomocysteinase Activity Microplate Assay Kit Adenosylhomocysteinase Activity Fluorometric Microplate Assay Kit 9026-93-1 Biochemicals and Reagents BioChemical Metabolomics 3.x.x.x Hydrolases 3.5.x.x Acting on C-N other than peptides
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