4-(Chloromethyl)pyridine hydrochloride
- CAS No.
- 1822-51-1
- Chemical Name:
- 4-(Chloromethyl)pyridine hydrochloride
- Synonyms
- 4-PICOLYL CHLORIDE HYDROCHLORIDE;4-Picolyl chloride;TIMTEC-BB SBB003917;4-Picolyl chloride h;4-(Chloromethyl)pyridine HCL;4-Plcolyl Chloride Hydrochloride;4-(Chloromethyl) Pyridine HCL 99%;4-(Chloromethyl)pyridine hydrochl;4-(CHLOROMETHYL)PYRIDINIUM CHLORIDE;4-Picolyl chloride hydrochloride,97%
- CBNumber:
- CB8380214
- Molecular Formula:
- C6H6ClN.ClH
- Molecular Weight:
- 164.03
- MDL Number:
- MFCD00012826
- MOL File:
- 1822-51-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-(Chloromethyl)pyridine hydrochloride 97% | P43807 | 10g | $27.3 |
| 4-(Chloromethyl)pyridine hydrochloride 97% | P43807 | 100g | $175 |
| 4-(Chloromethyl)pyridine Hydrochloride >98.0%(HPLC)(T) | C0805 | 25g | $96 |
| 4-(Chloromethyl)pyridine Hydrochloride >98.0%(HPLC)(T) | C0805 | 250g | $574 |
| 4-Chloromethylpyridine HCl Asreported | 267367 | 50g | $396 |
| More product size | |||
| Melting point | 166-173 °C(lit.) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | soluble in DMSO, Methanol |
| form | Fine Crystalline Powder |
| color | Yellow to orange |
| Water Solubility | 750 g/L (20 ºC) |
| Sensitive | Hygroscopic |
| BRN | 3689154 |
| InChI | InChI=1S/C6H6ClN.ClH/c7-5-6-1-3-8-4-2-6;/h1-4H,5H2;1H |
| InChIKey | ZDHKVKPZQKYREU-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(CCl)=C1.[H]Cl |
| CAS DataBase Reference | 1822-51-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 34-4-22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45-36 | |||||||||
| RIDADR | UN 3261 8/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-(Chloromethyl)pyridine hydrochloride price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P43807 | 4-(Chloromethyl)pyridine hydrochloride 97% | 1822-51-1 | 10g | $27.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | P43807 | 4-(Chloromethyl)pyridine hydrochloride 97% | 1822-51-1 | 100g | $175 | 2026-04-30 | Buy |
| TCI Chemical | C0805 | 4-(Chloromethyl)pyridine Hydrochloride >98.0%(HPLC)(T) | 1822-51-1 | 25g | $96 | 2026-04-30 | Buy |
| TCI Chemical | C0805 | 4-(Chloromethyl)pyridine Hydrochloride >98.0%(HPLC)(T) | 1822-51-1 | 250g | $574 | 2026-04-30 | Buy |
| Usbiological | 267367 | 4-Chloromethylpyridine HCl Asreported | 1822-51-1 | 50g | $396 | 2026-06-03 | Buy |
4-(Chloromethyl)pyridine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
YELLOW TO ORANGE FINE CRYSTALLINE POWDER
Uses
It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.
Application
4-Picolyl Chloride Hydrochloride is used for protection of alcohols, phenols, thiols, and carboxylic acids.
Synthesis
586-95-8
1822-51-1
Synthesis of 4-chloromethylpyridine hydrochloride (21): 4-Pyridine methanol (20) (54.4 g, 0.50 mol) was dissolved in 202 ml of acetonitrile. The solution was slowly added dropwise to a mixed solution containing thionyl chloride (65.3 g, 0.55 mol) and acetonitrile (109 ml) at 50 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 50 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature to give a slurry product (quantitative yield) of 4-chloromethylpyridine hydrochloride (21). The product was characterized by 1H-NMR (DMSO-d6, with TMS as internal standard): δ 5.09 (s, 2H), 8.09 (d, J = 6.6 Hz, 2H), 8.94 (d, J = 6.6 Hz, 2H).
storage
The free base is reported to be unstable, and should be generated shortly before use.
Purification Methods
Purify it by recrystallisation from EtOH or EtOH/dry Et2O. It melts between 171o and 175o, and the clear melt resolidifies on further heating at 190o and turns red to black at 280o but does not melt again. The picrate-hydrochloride (prepared in EtOH) has m 146-147o. The free base is an oil. [Mosher & Tessieri J Am Chem Soc 73 4925 1951, Beilstein 20 III/IV 2752.]
References
[1] Patent: US2003/195363, 2003, A1. Location in patent: Page/Page column 13
[2] Patent: US6057448, 2000, A
[3] ChemMedChem, 2015, vol. 10, # 11, p. 1875 - 1883
4-(Chloromethyl)pyridine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 | mina@chuanghaibio.com | China | 18126 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | lbaochemicals@gmail.com | China | 670 | 58 | |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
View Lastest Price from 4-(Chloromethyl)pyridine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | 4-(Chloromethyl)pyridine hydrochloride
1822-51-1
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2026-05-18 | ALLURA RED AC
1822-51-1
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2025-11-18 | 4-(Chloromethyl)pyridine hydrochloride
1822-51-1
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- 4-(Chloromethyl)pyridine hydrochloride
1822-51-1
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- ALLURA RED AC
1822-51-1
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 4-(Chloromethyl)pyridine hydrochloride
1822-51-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
