O-BENZYL-L-SERINE
- CAS No.
- 4726-96-9
- Chemical Name:
- O-BENZYL-L-SERINE
- Synonyms
- H-ser(Obzl)-OH;H-SER(BZL)-OH;BENZYL-L-SERINE;H-L-SER(BZL)-OH;L-Serine, O-(phenylmethyl)-;L-Ser(Bzl)-OH;SERINE(BZL)-OH;L-O-Benzylserine;O-BENZYL-L-SERINE;O-benzyl-L-aerine
- CBNumber:
- CB8439589
- Molecular Formula:
- C10H13NO3
- Molecular Weight:
- 195.22
- MDL Number:
- MFCD00065937
- MOL File:
- 4726-96-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| O-Benzyl-L-serine ≥99.0% (NT) | 13900 | 5G | $103 |
| O-Benzyl-L-serine >99.0%(T) | B0861 | 1g | $18 |
| O-Benzyl-L-serine >99.0%(T) | B0861 | 5g | $49 |
| O-Benzyl-L-serine 99+% (HPLC) ≥99%(HPLC) | 241019 | 1g | $154 |
| O-Benzyl-L-serine 99+% (HPLC) ≥99%(HPLC) | 241019 | 5g | $190 |
| More product size | |||
| Melting point | ~227 °C (dec.) |
|---|---|
| Boiling point | 359℃ |
| Density | 1.217 |
| refractive index | 7.3 ° (C=2, 1mol/L HCl) |
| Flash point | 171℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Powder |
| pka | 2.10±0.10(Predicted) |
| color | White to off-white |
| optical activity | [α]20/D +21±2°, c = 2% in acetic acid: water (4:1) (+ 1 Eq HCl) |
| BRN | 2114846 |
| Major Application | peptide synthesis |
| InChI | 1S/C10H13NO3/c11-9(10(12)13)7-14-6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)/t9-/m0/s1 |
| InChIKey | IDGQXGPQOGUGIX-VIFPVBQESA-N |
| SMILES | N[C@@H](COCc1ccccc1)C(O)=O |
| CAS DataBase Reference | 4726-96-9(CAS DataBase Reference) |
| EPA Substance Registry System | L-Serine, O-(phenylmethyl)- (4726-96-9) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P362+P364 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29225090 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| NFPA 704 |
|
O-BENZYL-L-SERINE price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 13900 | O-Benzyl-L-serine ≥99.0% (NT) | 4726-96-9 | 5G | $103 | 2022-05-15 | Buy |
| TCI Chemical | B0861 | O-Benzyl-L-serine >99.0%(T) | 4726-96-9 | 1g | $18 | 2026-04-30 | Buy |
| TCI Chemical | B0861 | O-Benzyl-L-serine >99.0%(T) | 4726-96-9 | 5g | $49 | 2026-04-30 | Buy |
| Usbiological | 241019 | O-Benzyl-L-serine 99+% (HPLC) ≥99%(HPLC) | 1g | $154 | 2026-06-03 | Buy | |
| Usbiological | 241019 | O-Benzyl-L-serine 99+% (HPLC) ≥99%(HPLC) | 5g | $190 | 2026-06-03 | Buy |
O-BENZYL-L-SERINE Chemical Properties,Uses,Production
Chemical Properties
Crystalline
Uses
O-Benzyl-L-Serine is used in the preparation of serine analogs as specific agonists for NMDA receptor glycine binding sites. It also functions as an eluent for ligand exchange chromatography for the separation of constrained glutamate receptor ligands.
Definition
ChEBI: O-BENZYL-l-SERINE is a L-alpha-amino acid.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
23680-31-1
4726-96-9
The general procedure for the synthesis of (S)-2-amino-3-(benzyloxy)propionic acid from N-BOC-O-benzyl-L-serine was as follows: the compound obtained in the previous step was dissolved in an appropriate amount of dry dichloromethane (DCM), 1.0 mL of trifluoroacetic acid (TFA) and 0.1 mL of triethylsilane were added, and the reaction was stirred for 2 hr at room temperature, and the reaction was monitored by thin-layer chromatography (TLC) The reaction was monitored until complete. Upon completion of the reaction, the pH of the reaction solution was adjusted to 78 with saturated sodium bicarbonate solution and subsequently diluted with the addition of dichloromethane (DCM). The organic phase was washed twice with saturated brine and then concentrated to give a yellow oily liquid. Finally, the product was purified by silica gel column chromatography (eluent ratio of chloroform:methanol=15:1) to give a yellow powdery solid product in 62.3% yield.
References
[1] Patent: CN107082754, 2017, A. Location in patent: Paragraph 0119; 0124
[2] Organic Process Research and Development, 2003, vol. 7, # 4, p. 521 - 532
[3] Tetrahedron Letters, 2014, vol. 55, # 30, p. 4149 - 4151
[4] ACS Chemical Neuroscience, 2017, vol. 8, # 8, p. 1681 - 1687
[5] Patent: WO2017/189866, 2017, A1. Location in patent: Paragraph 0210
O-BENZYL-L-SERINE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3796 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 15301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
View Lastest Price from O-BENZYL-L-SERINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-12 | O-Benzyl-L-serine
4726-96-9
|
$1.00-22.00 | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-08-31 | O-BENZYL-L-SERINE
4726-96-9
|
$100.00 | 1bag | 99 | 5000 | Hebei Fengqiang Trading Co., LTD | |
 |
2019-07-06 | O-BENZYL-L-SERINE
4726-96-9
|
$1.00 | 1kg | 99% | Career Henan Chemical Co |
-
- O-Benzyl-L-serine
4726-96-9
- $1.00-22.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- O-BENZYL-L-SERINE
4726-96-9
- $100.00
- 99
- Hebei Fengqiang Trading Co., LTD
-
- O-BENZYL-L-SERINE
4726-96-9
- $1.00
- 99%
- Career Henan Chemical Co
