8-bromo-1,2,3,4-tetrahydroisoquinoline
- CAS No.
- 75416-51-2
- Chemical Name:
- 8-bromo-1,2,3,4-tetrahydroisoquinoline
- Synonyms
- 8-BroMo-1,2,3,4-tetrahydroisoquinline;8-bromo-1,2,3,4-tetrahydroisoquinoline;Isoquinoline, 8-broMo-1,2,3,4-tetrahydro-;Isoquinoline, 8-bromo-1,2,3,4-tetrahydro-, hydrochloride (1:1)
- CBNumber:
- CB8547345
- Molecular Formula:
- C9H10BrN
- Molecular Weight:
- 212.09
- MDL Number:
- MFCD10001500
- MOL File:
- 75416-51-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 8-Bromo-1,2,3,4-tetrahydroisoquinoline 97% | AS47189 | 1g | $65 |
| 8-Bromo-1,2,3,4-tetrahydroisoquinoline 97% | AS47189 | 5g | $264 |
| 8-Bromo-1,2,3,4-tetrahydroisoquinoline | 124288 | 1.00g | $1073 |
| 8-Bromo-1,2,3,4-tetrahydroisoquinoline 95+% | B14753 | 1g | $60 |
| 8-Bromo-1,2,3,4-tetrahydroisoquinoline 95+% | B14753 | 5g | $200 |
| More product size | |||
| Boiling point | 294℃ |
|---|---|
| Density | 1.428 |
| Flash point | 132℃ |
| storage temp. | 2-8°C(protect from light) |
| pka | 8.88±0.20(Predicted) |
| Appearance | Off-white to yellow Solid-liquid mixture |
| InChI | InChI=1S/C9H10BrN/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-3,11H,4-6H2 |
| InChIKey | KHWGHUZYXQPIKA-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=CC=C2Br)CCN1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
8-bromo-1,2,3,4-tetrahydroisoquinoline price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS47189 | 8-Bromo-1,2,3,4-tetrahydroisoquinoline 97% | 75416-51-2 | 1g | $65 | 2026-06-04 | Buy |
| Activate Scientific | AS47189 | 8-Bromo-1,2,3,4-tetrahydroisoquinoline 97% | 75416-51-2 | 5g | $264 | 2026-06-04 | Buy |
| Matrix Scientific | 124288 | 8-Bromo-1,2,3,4-tetrahydroisoquinoline | 75416-51-2 | 1.00g | $1073 | 2026-05-18 | Buy |
| Synthonix | B14753 | 8-Bromo-1,2,3,4-tetrahydroisoquinoline 95+% | 75416-51-2 | 1g | $60 | 2026-05-06 | Buy |
| Synthonix | B14753 | 8-Bromo-1,2,3,4-tetrahydroisoquinoline 95+% | 75416-51-2 | 5g | $200 | 2026-05-06 | Buy |
8-bromo-1,2,3,4-tetrahydroisoquinoline Chemical Properties,Uses,Production
Uses
8-Bromo-1,2,3,4-tetrahydroisoquinoline is a useful intermediate for organic synthesis.
Uses
8-Bromo-1,2,3,4-tetrahydroisoquinoline is a useful intermediate for organic synthesis.
Synthesis
252331-63-8
726136-49-8
226942-29-6
75416-51-2
To a solvent mixture of methanol (20 mL) and saturated aqueous sodium carbonate (20 mL) was added 1-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroacetophenone mixed with 1-(8-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethanone (3 g, 9.7 mmol). The reaction mixture was heated to reflux overnight and subsequently concentrated. The residue was extracted with dichloromethane, the organic layers were combined, washed sequentially with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The crude product was purified by silica gel column chromatography (230-400 mesh) with 0-2% methanol/chloroform solution as eluent to give 8-bromo-1,2,3,4-tetrahydroisoquinoline (first fraction, colorless viscous oil, 0.45 g, 22% yield) and 6-bromo-1,2,3,4-tetrahydroisoquinoline (second fraction, white solid, 1.0 g, 48% yield) sequentially. Mass spectrum (MS) m/z: 211.9 [M + H]+.
References
[1] Patent: WO2008/76954, 2008, A2. Location in patent: Page/Page column 50
[2] Patent: US2008/171754, 2008, A1. Location in patent: Page/Page column 101; 102
[3] Patent: WO2009/39134, 2009, A1. Location in patent: Page/Page column 179
[4] Patent: WO2006/65215, 2006, A1. Location in patent: Page/Page column 17; 24
[5] Patent: WO2006/65216, 2006, A1. Location in patent: Page/Page column 16; 24
8-bromo-1,2,3,4-tetrahydroisoquinoline Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29793 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8886 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| CR Corporation Limited | fred.wen@crcorporation.cn | China | 8645 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25356 | 58 |
View Lastest Price from 8-bromo-1,2,3,4-tetrahydroisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-15 | 8-bromo-1,2,3,4-tetrahydroisoquinoline
75416-51-2
|
1g | 98%min | 10g,100g,1kg | Career Henan Chemical Co |
-
- 8-bromo-1,2,3,4-tetrahydroisoquinoline
75416-51-2
- $0.10
- 98%min
- Career Henan Chemical Co
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