Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Protein phosphatase 5 is a member of the serine/threonine phosphatase family that also includes PP1, PP2A and PP2B. PP5 uniquely contains an amino-terminal regulatory domain with three tetratricopeptide repeat motifs and a carboxy-terminal catalytic domain. Through the TPR domain, PP5 interacts with a number of proteins and has been reported to be involved in diverse signal transduction pathways, including glucocorticoid receptor signaling, p53-mediated growth arrest, oxidative stress-mediated apoptosis and the response to ionizing radiation-induced DNA damage.

References

[1] Chen, M.X. and Cohen, P.T. (1997) FEBS Lett. 400, 136-140.
[2] Andreeva, A.V. and Kutuzov, M.A. (1999) Cell. Signal. 11, 555-562.
[3] Chinkers, M. Trends Endocrinol. Metab. 12, 28-32.
[4] Zuo, Z. et al. (1998) J. Biol. Chem. 273, 12250-12258.
[5] Morita, K. et al. (2001) EMBO J. 20, 6028-6036.
[6] Silverstein, A.M. et al. (1997) J. Biol. Chem. 272, 16224-16230.
[7] Ali, A. et al. (2004) Genes Dev. 18, 249-254.
[8] Wechsler, T. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 1247-1252.

Raw materials

Preparation Products