Source

Rat

Reactivity

Human;Mouse;Rat;Hamster;Monkey;Bovine

Background

Pirin is a highly conserved nuclear protein and a member of the cupin superfamily of proteins, all of which contain two conserved β-barrel fold domains. Pirin functions as a co-factor for NFI/CTF1 and Bcl-3, implicating it in DNA replication, transcriptional activation and apoptosis. Both human and bacterial pirins catalyze the di-oxygenation of quercetin, one of a class of widespread naturally occurring flavenoid compounds that have anti-inflammatory and anti-cancer activities. Flavenoids exert these beneficial activities by functioning as antioxidants that stabilize cellular free radical molecules and by directly modulating cell signaling pathways involving PI 3-kinase, Akt/PKB, PKC and MAP kinases. Quercetin has also been directly implicated in the regulation of NF-κB activity; thus, Pirin may exert its apoptotic functions both by directly regulating Bcl-3/NF-κB activity and by modulating quercetin levels in the cell.

References

[1] Dunwell, J.M. et al. (2001) Trends Biochem. Sci. 26, 740-746.
[2] Wendler, W.M. et al. (1997) J. Biol. Chem. 272, 8482-8489.
[3] Dechend, R. et al. (1999) Oncogene 18, 3316-3323.
[4] Adams, M. and Jia, Z. (2005) J. Biol. Chem. 280, 28675-28682.
[5] Williams, R.J. et al. (2004) Free Radic. Biol .Med. 36, 838-849.
[6] Chen, C.C. et al. (2004) Mol. Pharmacol. 66, 683-693.

Raw materials

Preparation Products