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AKAP5 (D28G3) Rabbit mAb

CAS No.
Chemical Name:
AKAP5 (D28G3) Rabbit mAb
Synonyms
AKAP5 (D28G3) Rabbit mAb
CBNumber:
CB85710436
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

AKAP5 (D28G3) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human

Background

AKAPs, as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A thus localizing PKA activity to distinct regions of the cell. Beyond a common amphipathic alpha helix that is responsible for recruiting the PKA regulatory subunit, individual AKAPs contain additional domains responsible for the recruitment of additional signaling proteins or restricting AKAP to a specific subcellular location. AKAP5 is predominantly expressed in neuronal tissues and cells where it serves to localize type II PKA to post-synaptic densities. AKAP5 specifically binds to the regulatory subunit of PKAIIβ, anchoring the enzyme to the plasma membrane and sites of cytoskeletal/membrane junctions. The other binding domains of AKAP5 have been shown to interact with calmodulin, PP2B, and calcineurin suggesting that AKAP5 may act to coordinate the cAMP- and Ca2+-sensing pathways in various cell types.

References

[1] Schwartz, J.H. (2001) Proc Natl Acad Sci U S A 98, 13482-4.
[2] Bregman, D.B. et al. (1991) J Biol Chem 266, 7207-13.
[3] Hirsch, A.H. et al. (1992) J Biol Chem 267, 2131-4.
[4] Carr, D.W. et al. (1992) J Biol Chem 267, 16816-23.
[5] Glantz, S.B. et al. (1993) J Biol Chem 268, 12796-804.
[6] Klauck, T.M. et al. (1996) Science 271, 1589-92.
[7] Sarkar, D. et al. (1984) J Biol Chem 259, 9840-6.
[8] Coghlan, V.M. et al. (1995) Science 267, 108-11.

AKAP5 (D28G3) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

AKAP5 (D28G3) Rabbit mAb Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Supplier Advantage
Cell Signaling Technology Inc 58
AKAP5 (D28G3) Rabbit mAb
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