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JNK3 (55A8) Rabbit mAb

CAS No.
Chemical Name:
JNK3 (55A8) Rabbit mAb
Synonyms
JNK3 (55A8) Rabbit mAb
CBNumber:
CB85738786
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

JNK3 (55A8) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, growth factors and GPCR agonists. As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases, which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase. Stress signals are delivered to this cascade by small GTPases of the Rho family. Both Rac1 and cdc42 mediate the stimulation of MEKKs and MLKs. Alternatively, MKK4/7 can be activated in a GTPase-independent mechanism via stimulation of a germinal center kinase family member. There are three SAPK/JNK genes each of which undergoes alternative splicing, resulting in numerous isoforms. SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors.

References

[1] Davis, R.J. (1999) Biochem Soc Symp 64, 1-12.
[2] Ichijo, H. (1999) Oncogene 18, 6087-3.
[3] Kyriakis, J.M. and Avruch, J. (2001) Physiol Rev 81, 807-69.
[4] Kyriakis, J.M. (1999) J Biol Chem 274, 5259-62.
[5] Lepp?, S. and Bohmann, D. (1999) Oncogene 18, 6158-62.
[6] Whitmarsh, A.J. and Davis, R.J. (1998) Trends Biochem Sci 23, 481-5.

JNK3 (55A8) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

JNK3 (55A8) Rabbit mAb Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Guangzhou Keda Heng New Technology Co., Ltd. 17328662120 CHINA 6139 58
Hangzhou Novas Biotechnology Co., Ltd. 15264006066 CHINA 1844 58
JNK3 (55A8) Rabbit mAb
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