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Na Channel β2 Subunit (D1S8E) Rabbit mAb

CAS No.
Chemical Name:
Na Channel β2 Subunit (D1S8E) Rabbit mAb
Synonyms
Na Channel β2 Subunit (D1S8E) Rabbit mAb
CBNumber:
CB85744736
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Na Channel β2 Subunit (D1S8E) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Mammalian voltage-gated sodium channels are composed of a pore-forming α subunit and one or more regulatory β subunits. Four separate genes encode the five mammalian β subunits β1, β1B, β2, β3, and β4. In general, β subunit proteins are type I transmembrane proteins, with the exception of secreted β1B protein. β subunits regulate α subunit gating and kinetics, which controls cell excitability. Sodium channel β subunits also function as Ig superfamily cell adhesion molecules that regulate cell adhesion and migration. Additional research reveals sequential processing of β subunit proteins by β-secretase and γ secretase, resulting in ectodomain shedding of β subunit and generation of an intracellular carboxy-terminal fragment. Generation of the CTF is thought to play a role in cell adhesion and migration. Multiple studies demonstrate a link between β subunit gene mutations and a number of disorders, including epilepsy, cardiac arrhythmia, multiple sclerosis, neuropsychiatric disorders, neuropathy, inflammatory pain, and cancer.The sodium channel β2 subunit plays a role in the assembly and functioning of cell surface sodium channels. Mutations in the corresponding SCN2B gene may be associated with a form of atrial fibrillation and at least one identified case of Brugada syndrome. Research using a rat model of spared nerve injury suggests that the β2 subunit may be involved in the generation of neuropathic pain.

References

[1] Catterall, W.A. (1992) Physiol Rev 72, S15-48.
[2] Catterall, W.A. (2012) J Physiol 590, 2577-89.
[3] Isom, L.L. et al. (1992) Science 256, 839-42.
[4] Brackenbury, W.J. and Isom, L.L. (2011) Front Pharmacol 2, 53.
[5] Isom, L.L. et al. (1995) Cell 83, 433-42.
[6] Malhotra, J.D. et al. (2000) J Biol Chem 275, 11383-8.
[7] Wong, H.K. et al. (2005) J Biol Chem 280, 23009-17.
[8] Kim, D.Y. et al. (2005) J Biol Chem 280, 23251-61.
[9] Wallace, R.H. et al. (1998) Nat Genet 19, 366-70.
[10] Lopez-Santiago, L.F. et al. (2007) J Mol Cell Cardiol 43, 636-47.

Na Channel β2 Subunit (D1S8E) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

Na Channel β2 Subunit (D1S8E) Rabbit mAb Suppliers

Na Channel β2 Subunit (D1S8E) Rabbit mAb
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