Source

Rabbit

Reactivity

Human

Background

Notch proteins are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer composed of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit. Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes.Notch2 is a member of Notch family and mutation in Notch2 is associated with Alagille syndrome.

References

[1] Artavanis-Tsakonas, S. et al. (1999) Science 284, 770-6.
[2] Chan, Y.M. and Jan, Y.N. (1998) Cell 94, 423-6.
[3] Schroeter, E.H. et al. (1998) Nature 393, 382-6.
[4] Rand, M.D. et al. (2000) Mol Cell Biol 20, 1825-35.
[5] McDaniell, R. et al. (2006) Am J Hum Genet 79, 169-73.

Raw materials

Preparation Products