Source

Mouse

Reactivity

Human;Mouse;Rat

Background

Glycogen synthase kinase-3 was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.

References

[1] Welsh, G.I. et al. (1996) Trends Cell Biol 6, 274-9.
[2] Srivastava, A.K. and Pandey, S.K. (1998) Mol Cell Biochem 182, 135-41.
[3] Cross, D.A. et al. (1995) Nature 378, 785-9.
[4] Nusse, R. (1997) Cell 89, 321-3.
[5] Diehl, J.A. et al. (1998) Genes Dev 12, 3499-511.

Raw materials

Preparation Products