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p190-A RhoGAP (C59F7) Rabbit mAb

CAS No.
Chemical Name:
p190-A RhoGAP (C59F7) Rabbit mAb
Synonyms
p190-A RhoGAP (C59F7) Rabbit mAb
CBNumber:
CB86262581
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

p190-A RhoGAP (C59F7) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human;Mouse;Rat;Hamster;Monkey

Background

Rho family GTPases are key regulators of diverse processes such as cytoskeletal organization, cell growth and differentiation, transcriptional regulation, and cell adhesion/motility. The activities of these proteins are controlled primarily through guanine nucleotide exchange factors that facilitate the exchange of GDP for GTP, promoting the active state, and GTPase activating proteins that promote GTP hydrolysis and the inactive state.The p190 RhoGAP proteins are widely expressed Rho family GAPs. p190-A has been characterized as a tumor suppressor, and research studies have shown that loss or rearrangement of the chromosomal region containing the gene for p190-A is linked to tumor development. p190-A binds the mitogen-inducible transcription factor TFII-I, sequestering it in the cytoplasm and inhibiting its activity. Phosphorylation of p190-A at Tyr308 reduces its affinity for TFII-I, relieving the inhibition. p190-A can also inhibit growth factor-induced gliomas in mice and affect cleavage furrow formation and cytokinesis in cultured cells.Mice lacking p190-B RhoGAP show excessive Rho activation and a reduction in activation of the transcription factor CREB. Cells deficient in p190-B display defective adipogenesis. There is increasing evidence that p190 undergoes tyrosine phosphorylation, which activates its GAP domain. Levels of tyrosine phosphorylation are enhanced by Src overexpression. IGF-I treatment downregulates Rho through phosphorylation and activation of p190-B RhoGAP, thereby enhancing IGF signaling implicated in adipogenesis.

References

[1] Peck, J. et al. (2002) FEBS Lett 528, 27-34.
[2] Moon, S.Y. and Zheng, Y. (2003) Trends Cell Biol 13, 13-22.
[3] Wang, Z. et al. (1996) Cell Growth Differ 7, 123-33.
[4] Tikoo, A. et al. (2000) Gene 257, 23-31.
[5] Jiang, W. et al. (2005) Mol Cell 17, 23-35.
[6] Wolf, R.M. et al. (2003) Genes Dev 17, 476-87.
[7] Su, L. et al. (2003) J Cell Biol 163, 571-82.
[8] Sordella, R. et al. (2002) Dev Cell 2, 553-565.
[9] Sordella, R. et al. (2003) Cell 113, 147-158.
[10] Chang, J.H. et al. (1995) J Cell Biol 130, 355-368.

p190-A RhoGAP (C59F7) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

p190-A RhoGAP (C59F7) Rabbit mAb
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