2-BROMO-5-METHOXYANILINE
- CAS No.
- 59557-92-5
- Chemical Name:
- 2-BROMO-5-METHOXYANILINE
- Synonyms
- 2-bromo-5-methoxybenzenamine;6-Bromo-m-anisidine;2-BROMO-5-METHOXYANI;4-Bromo-3-amino anisole;2-BROMO-5-METHOXYANILINE;2-Bromo-5-methoxyaniline 97%;2-BroMo-5-Methoxy-phenylaMine;Benzenamine, 2-bromo-5-methoxy-;2-Bromo-5-Methoxyaniline (In HCl salt form);3-Amino-4-bromoanisole, 6-Bromo-m-anisidine
- CBNumber:
- CB8729750
- Molecular Formula:
- C7H8BrNO
- Molecular Weight:
- 202.05
- MDL Number:
- MFCD00070741
- MOL File:
- 59557-92-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Bromo-5-methoxyaniline | CDS020665 | 100 mg | $39.1 |
| 2-BROMO-5-METHOXY-PHENYLAMINE 98% | CX1205 | 5G | $30 |
| 2-BROMO-5-METHOXY-PHENYLAMINE 98% | CX1205 | 25G | $65 |
| 2-BROMO-5-METHOXY-PHENYLAMINE 98% | CX1205 | 100G | $160 |
| 2-Bromo-5-methoxyaniline 98% | AS40186-A | 5g | $20 |
| More product size | |||
| Melting point | 189-190°C |
|---|---|
| Boiling point | 280.1±20.0 °C(Predicted) |
| Density | 1.531±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | solid |
| pka | 2.11±0.10(Predicted) |
| Appearance | Brown to black Solid-liquid mixture |
| InChI | 1S/C7H8BrNO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3 |
| InChIKey | PRQDMSJEMCRFMI-UHFFFAOYSA-N |
| SMILES | NC1=CC(OC)=CC=C1Br |
| CAS DataBase Reference | 59557-92-5(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P280-P271 |
| target organs | Respiratory system |
| Hazard Codes | Xi |
| WGK Germany | WGK 3 |
| HS Code | 29222990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2-BROMO-5-METHOXYANILINE price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS020665 | 2-Bromo-5-methoxyaniline | 100 mg | $39.1 | 2026-04-30 | Buy | |
| AstaTech | CX1205 | 2-BROMO-5-METHOXY-PHENYLAMINE 98% | 59557-92-5 | 5G | $30 | 2026-04-30 | Buy |
| AstaTech | CX1205 | 2-BROMO-5-METHOXY-PHENYLAMINE 98% | 59557-92-5 | 25G | $65 | 2026-04-30 | Buy |
| AstaTech | CX1205 | 2-BROMO-5-METHOXY-PHENYLAMINE 98% | 59557-92-5 | 100G | $160 | 2026-04-30 | Buy |
| Activate Scientific | AS40186-A | 2-Bromo-5-methoxyaniline 98% | 59557-92-5 | 5g | $20 | 2026-06-04 | Buy |
2-BROMO-5-METHOXYANILINE Chemical Properties,Uses,Production
Uses
2-Bromo-5-methoxyaniline is used as a synthetic material intermediate for the preparation of epidermal growth factor receptor inhibitors, urolithin derivatives and melatonergic ligands. It is also an OLED intermediate for organic electroluminescent devices.
Synthesis
5344-78-5
59557-92-5
1. 4-Bromo-3-nitroanisole (1.71 g, 7.2 mmol, 1 eq.) was dissolved in a solvent mixture of ethanol (7 mL) and water (5 mL). 2. To the above solution was added iron powder (2.00 g, 35.7 mmol, 5 eq.) and ammonium chloride (1.53 g, 28.6 mmol, 4 eq.). 3. The reaction mixture was heated to reflux for 2 hours. 4. Upon completion of the reaction, the black organic phase was extracted with ether (4 x 100 mL). 5. The organic phase was separated to give 2-bromo-5-methoxyaniline in 95% yield as a green solid. 6. 2-Bromo-5-methoxyaniline (1.50 g, 7.4 mmol, 1 eq.), the crude product, was dissolved in concentrated hydrochloric acid (7 mL) at 0 °C. 7. To the above solution was added dropwise an aqueous solution of sodium nitrite (0.5 g, 7.2 mmol, 1 eq.) (5 mL) at 0 °C. 8. Continue stirring for 5 hours at 0 °C to form the diazonium salt. 9. In another flask, treat water (8 mL) with thionyl chloride (2.2 mL, 30.3 mmol, 4 eq.) at 0 °C. 10. Stirring was continued for 1 hour at 0 °C. 11. Wash the aqueous phase with ethyl acetate (6 x 50 mL). 12. Combine the organic phases and dry with magnesium sulfate. 13. The solvent was removed under pressure and the product was purified by column chromatography (n-hexane-ethyl acetate, 5:1) to afford the target product S5 (1.50 g, 46%) as a yellow oil. 14. The Rf value of the product was 0.3 (n-hexane-ethyl acetate, 5:1), which was in agreement with the data reported in the literature.
References
[1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 6, p. 950 - 957
[3] Organic Letters, 2015, vol. 17, # 4, p. 802 - 805
[4] Tetrahedron Letters, 2017, vol. 58, # 48, p. 4559 - 4562
[5] Journal of the American Chemical Society, 1994, vol. 116, # 26, p. 11797 - 11810
2-BROMO-5-METHOXYANILINE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3861 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 2-BROMO-5-METHOXYANILINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-12 | 2-BROMO-5-METHOXYANILINE
59557-92-5
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
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- 2-BROMO-5-METHOXYANILINE
59557-92-5
- $1.00
- 99%
- Career Henan Chemical Co
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