Meptazinol
- CAS No.
- 54340-58-8
- Chemical Name:
- Meptazinol
- Synonyms
- Meptalol;MeptaMizol;MEPTAZINOL;Meptazinol A;Meptazinol-13C-d3;Meptazinol USP/EP/BP;MEPTAZINOL 54340-58-8;3-(3-ethyl-1-Methylazepan-3-yl)phenol;3-(1-Methyl-3-ethylhexahydro-1H-azepine-3-yl)phenol;3-(3-ethylhexahydro-1-methyl-1h-azepin-3-yl)-phenol
- CBNumber:
- CB8841562
- Molecular Formula:
- C15H23NO
- Molecular Weight:
- 233.35
- MDL Number:
- MFCD00864339
- MOL File:
- 54340-58-8.mol
| Product description | Number | Pack Size | Price |
| MEPTAZINOL 95.00% | API0008709 | 1MG | $460 |
| MEPTAZINOL 95.00% | API0008709 | 5MG | $518 |
| MEPTAZINOL 95.00% | API0008709 | 10MG | $574 |
| 3-(3-ethyl-1-methylazepan-3-yl)phenol 97% | CM200523 | 5g | $505 |
| More product size | |||
| Melting point | 127-133°C |
|---|---|
| Boiling point | 354.8±35.0 °C(Predicted) |
| Density | 0.997 |
| pka | 9.95±0.10(Predicted) |
| FDA UNII | 18Y7S5JKZD |
| ATC code | N02AX05 |
Meptazinol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0008709 | MEPTAZINOL 95.00% | 54340-58-8 | 1MG | $460 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008709 | MEPTAZINOL 95.00% | 54340-58-8 | 5MG | $518 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008709 | MEPTAZINOL 95.00% | 54340-58-8 | 10MG | $574 | 2021-12-16 | Buy |
| Chemenu | CM200523 | 3-(3-ethyl-1-methylazepan-3-yl)phenol 97% | 54340-58-8 | 5g | $505 | 2021-12-16 | Buy |
Meptazinol Chemical Properties,Uses,Production
Originator
Meptid,Wyeth,UK,1983
Uses
Analgesic.
Definition
ChEBI: 3-(3-ethyl-1-methyl-3-azepanyl)phenol is a member of azepanes.
Manufacturing Process
2-(m-Methoxyphenyl)butyronitrile in dry ether was added to a stirred suspension of sodium amide in liquid ammonia. The mixture was stirred for 30 minutes then ethyl-4-iodobutyrate (99.25 g, 0.4 mol) in dry ether (200 ml) was added dropwise. The mixture was stirred at the temperature of refluxing liquid ammonia for 5 hours. Ammonium chloride (10 g) was added and the mixture allowed to warm to room temperature. Water (300 ml) was added, the organic layer separated, washed with water, 2 N sulfuric acid and water. After drying over magnesium sulfate and removing the ether, the product was distilled yielding ethyl 5-cyano-5-(mmethoxyphenyl)heptanoate.
That material was hydrogenated in cyclohexane using a Raney nickel catalyst. The product after distillation was recrystallized from ethyl acetate affording 10.0 g of 6-ethyl-(m-methoxyphenyl)hexahydro-2H-azepin-2one, MP 87°C to 88°C.
The azepinone (9.1 g) in dry tetrahydrofuran (50 ml) and ether (50 ml) was added dropwise to a stirred suspension of aluminum lithium hydride (7.5 g) in dry ether (50 ml). After heating under reflux for 3 hours the reaction mixture was worked up and distilled yielding 7.66 g of a compound which was a colorless oil, BP 108°C to 110°C/0.01 mm.
That product was then heated under reflux with 50% hydrobromic acid for 1.5
hours. The reaction mixture was evaporated to dryness and reevaporated with
three portions of propan-2-ol. The oil obtained was dissolved in propan-2-ol
and diluted with ether. 3-Ethyl-3-(m-hydroxyphenyl)hexahydro-1H-azepine
was obtained. That material in turn was reductively methylated by
hydrogenation in the presence of formaldehyde in absolute ethanol solution to
give 3-ethyl-3-(m-methoxyphenyl)-1-methylhexahydro-1H-azepine.
The methoxy group was converted to a hydroxy group by refluxing with 80%
HBr giving meptazinol hydrobromide.
Therapeutic Function
Analgesic
Clinical Use
Opioid analgesic used for moderate to severe pain
Drug interactions
Potentially hazardous interactions with other drugs
Antidepressants: possible CNS excitation or
depression with MAOIs - avoid; possible CNS
excitation or depression with moclobemide; possibly
increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with
sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative
effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate
- avoid
Metabolism
Meptazinol is extensively metabolised in the liver and is excreted mainly in the urine as the glucuronide conjugate. Less than 10% of a dose has been recovered from the faeces.
Meptazinol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Moxin Chemicals | +86-17320513646 +86-17320513646 | anna@molcoo.com | China | 10000 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15079 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10457 | 58 |
| LUYUNJIA CHEMISTRY XIAMEN LIMITED | +86-592-5360779 +86-13055435203 | China | 5988 | 58 | |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
View Lastest Price from Meptazinol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-25 | Meptazinol
54340-58-8
|
1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited | ||
 |
2025-12-16 | Meptazinol Impurity
54340-58-8
|
10mg | 95%+ | 10000000 | Moxin Chemicals | ||
 |
2025-11-18 | Meptazinol USP/EP/BP
54340-58-8
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Meptazinol
54340-58-8
- $0.00
- 99%
- Zhejiang J&C Biological Technology Co.,Limited
-
- Meptazinol Impurity
54340-58-8
- 95%+
- Moxin Chemicals
-
- Meptazinol USP/EP/BP
54340-58-8
- $1.10
- 99.9%
- Dideu Industries Group Limited
