ChemicalBook >> CAS DataBase List >>trans-4-Dimethylaminocrotonic acid hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride
- CAS No.
- 848133-35-7
- Chemical Name:
- trans-4-Dimethylaminocrotonic acid hydrochloride
- Synonyms
- (E)-4-(dimethylamino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;THRX-196194;Afatinib intermediate E;trans-4-Dimethylaminocrotonic;(E)-4-(Dimethylamino)-2-buteno;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL;(2E)-4-(Dimethylamino)but-2-enoic acid HCl
- CBNumber:
- CB8854829
- Molecular Formula:
- C6H12ClNO2
- Molecular Weight:
- 165.62
- MDL Number:
- MFCD03695466
- MOL File:
- 848133-35-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 03:33:46
| Product description | Number | Pack Size | Price |
| (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride | D5625 | 1G | $31 |
| (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride | D5625 | 5G | $114 |
| trans 4-Dimethylaminocrotonic Acid Hydrochloride | TRC-D446630-1G | 1g | $142 |
| trans 4-Dimethylaminocrotonic Acid Hydrochloride | 009646 | 250mg | $418 |
| trans 4-Dimethylaminocrotonic acid HCl | FD22343 | 100g | $389 |
| More product size | |||
| Melting point | 162 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+; |
| InChIKey | UUHNQHFOIVLAQX-BJILWQEISA-N |
| SMILES | C(/CN(C)C)=C\C(=O)O.Cl |
| CAS DataBase Reference | 848133-35-7(CAS DataBase Reference) |
| FDA UNII | ZRA8B68TND |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| HS Code | 2922498590 | |||||||||
| NFPA 704 |
|
trans-4-Dimethylaminocrotonic acid hydrochloride price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D5625 | (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride | 848133-35-7 | 1G | $31 | 2026-04-30 | Buy |
| TCI Chemical | D5625 | (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride | 848133-35-7 | 5G | $114 | 2026-04-30 | Buy |
| TRC | TRC-D446630-1G | trans 4-Dimethylaminocrotonic Acid Hydrochloride | 848133-35-7 | 1g | $142 | 2026-06-03 | Buy |
| Usbiological | 009646 | trans 4-Dimethylaminocrotonic Acid Hydrochloride | 848133-35-7 | 250mg | $418 | 2026-06-03 | Buy |
| Biosynth | FD22343 | trans 4-Dimethylaminocrotonic acid HCl | 848133-35-7 | 100g | $389 | 2026-06-04 | Buy |
trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties,Uses,Production
Description
trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.
Chemical Properties
White Solid
Uses
trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.
Synthesis
trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.
trans-4-Dimethylaminocrotonic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 389)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 | info@senovatech.com | China | 351 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
View Lastest Price from trans-4-Dimethylaminocrotonic acid hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
|
1g | 99% | 100mt/year | Jinan Finer Chemical Co., Ltd | ||
 |
2026-07-09 | trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
|
$5.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-11-18 | trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited |
-
- trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
- $5.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
848133-35-7(trans-4-Dimethylaminocrotonic acid hydrochloride)Related Search:
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trans-4-Dimethylaminocrotonic acid hydrochloride
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Afatinib intermediate E
(2E)-4-(diMethylaMino)but-2-enoic acid hydrochloride
trans-4-(DiMethylaMino)-2-butenoic Acid Hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride (E)-4-(Dimethylamino)-2-butenoic acid hydrochloride
2-Butenoic acid,4-(dimethylamino)-, hydrochloride (1:1), (2E)-
trans-4-Dimethylaminocrotonic acid hydrochloride(848133-35-7)
(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL
(2E)-4-(dimethylamino)but-2-enoic acid hydrochloride, trans
2-Butenoic acid, 4-(dimethylamino)-, hydrochloride (1:1)
(2E)-4-(Dimethylamino)but-2-enoic acid?hydrochloride (1:1)
(E)-4-Dimethylaminocrotonic Acid Hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride ISO 9001：2015 REACH
(e)-4-(dimethylamino)-2-butenoic acid hydrochloride
THRX-196194
(E)-4-(Dimethylamino)-2-buteno
(2E)-4-(dimethylamino)-2-Butenoic acid hydrochloride (1:1)
(2E)-4-(Dimethylamino)but-2-enoic acid HCl
trans-4-Dimethylaminocrotonic acid hydrochloride，(E)-4-(Dimethylamino)But-2-Enoic Acid Hydrochloride
848133-35-7Trans-4-dimethylaminocrotonicacidhydrochloride
trans-4-Dimethylaminocrotonic acid HCl 98%
trans-4-Dimethylaminocrotonic acid hydrochloride
Afatinib Int
(E)-4-(dimethylamino)but-2-enoic acid hydrochloride
848133-35-7
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848133-35-7
