3-Bromo-2,4-difluoroaniline
- CAS No.
- 103977-79-3
- Chemical Name:
- 3-Bromo-2,4-difluoroaniline
- Synonyms
- 3-Bromo-2,4-difluoroaniline;3-Bromo-2,4-difluorophenylamine;3-Amino-2,6-difluorobromobenzene;BenzenaMine, 3-broMo-2,4-difluoro-;2-bromo-1,3-difluoro-4-aminobenzene;Hexanoicacid,5-methyl-6-oxo-,ethylester
- CBNumber:
- CB8970154
- Molecular Formula:
- C6H4BrF2N
- Molecular Weight:
- 208
- MDL Number:
- MFCD12407090
- MOL File:
- Mol file
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Bromo-2,4-difluoroaniline | DEA97779 | 50g | $590 |
| 3-Bromo-2,4-difluoroaniline ≥95% | PC49009 | 1g | $21 |
| 3-Bromo-2,4-difluoroaniline ≥95% | PC49009 | 5g | $40 |
| 3-Bromo-2,4-difluoroaniline 98% | AS48186 | 1g | $23 |
| 3-Bromo-2,4-difluoroaniline 98% | AS48186 | 5g | $39 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331 |
| Precautionary statements | P280 |
| HS Code | 2921420090 |
3-Bromo-2,4-difluoroaniline price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DEA97779 | 3-Bromo-2,4-difluoroaniline | 103977-79-3 | 50g | $590 | 2026-06-04 | Buy |
| Apolloscientific | PC49009 | 3-Bromo-2,4-difluoroaniline ≥95% | 103977-79-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC49009 | 3-Bromo-2,4-difluoroaniline ≥95% | 103977-79-3 | 5g | $40 | 2026-06-04 | Buy |
| Activate Scientific | AS48186 | 3-Bromo-2,4-difluoroaniline 98% | 103977-79-3 | 1g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS48186 | 3-Bromo-2,4-difluoroaniline 98% | 103977-79-3 | 5g | $39 | 2026-06-04 | Buy |
3-Bromo-2,4-difluoroaniline Chemical Properties,Uses,Production
Uses
3-Bromo-2,4-difluoroaniline is a fluoroaniline compound that is used in the preparation of pharmaceutical chemicals.
Synthesis
103977-78-2
103977-79-3
General procedure for the synthesis of 2,4-difluoro-3-bromoaniline from 2-bromo-1,3-difluoro-4-nitrobenzene: A mixture of 2-bromo-1,3-difluoro-4-nitrobenzene (30 g, 130 mmol) and tin (II) chloride dihydrate in 36% hydrochloric acid (150 ml) was heated to 40 °C. Ether (20 ml) was added slowly to form a homogeneous solution. The reaction then proceeded rapidly, accompanied by boiling of the ether. After continued heating at 60°C for 1 hour, the reaction mixture was cooled and subsequently poured into ice water (1.5 liters). The pH of the mixture was adjusted to 13 with a 30% aqueous sodium hydroxide solution, while the internal temperature was controlled below 20°C. The resulting gray slurry was vortex-extracted with chloroform (2 x 500 ml), the organic phases were combined, washed with water and subsequently dried over anhydrous magnesium sulfate containing 2 g of decolorized carbon. After filtration, the solvent was removed by evaporation to give the crude product. Grinding of the crude product with isohexane afforded 23 g (83% yield) of 2,4-difluoro-3-bromoaniline as a light yellow solid. The product was characterized by 1H NMR (360 MHz, CDCl3): δ 3.51 (2H, br), 6.65-6.70 (1H, m), 6.75-6.80 (1H, m).
References
[1] Patent: WO2003/93272, 2003, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5927 - 5932
[3] Patent: CN108117553, 2018, A. Location in patent: Paragraph 0105; 0106; 0122-0124
[4] Tetrahedron Letters, 2010, vol. 51, # 4, p. 600 - 601
[5] Patent: WO2015/54572, 2015, A1. Location in patent: Page/Page column 279
3-Bromo-2,4-difluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2971 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Hubei Ipure Biology Co., Ltd | +8618062405514 | ada@ipurechemical.com | China | 10224 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3453 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
View Lastest Price from 3-Bromo-2,4-difluoroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-08 | 3-Bromo-2,4-difluoroaniline
103977-79-3
|
$3.00 | 1KG | 98%min | 200KG | Career Henan Chemical Co |
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- 3-Bromo-2,4-difluoroaniline
103977-79-3
- $3.00
- 98%min
- Career Henan Chemical Co
