Methyl-3-bromopropiolate
- CAS No.
- 23680-40-2
- Chemical Name:
- Methyl-3-bromopropiolate
- Synonyms
- 182050;Bexarotene Impurity 21;Methyl 3-bromopropynoate;Methyl-3-bromopropiolate;Methyl 3-bromoprop-2-ynoate;2-Propynoic acid, 3-broMo-, Methyl ester;Methyl-3-bromopropiolate ISO 9001：2015 REACH
- CBNumber:
- CB91075079
- Molecular Formula:
- C4H3BrO2
- Molecular Weight:
- 162.97
- MDL Number:
- MFCD22989330
- MOL File:
- 23680-40-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 3-bromopropiolate | FM160166 | 1000mg | $150 |
| Methyl 3-bromopropiolate | FM160166 | 500mg | $150 |
| Methyl 3-bromopropiolate | FM160166 | 250mg | $150 |
| Methyl 3-bromopropiolate | FM160166 | 2000mg | $220 |
| Methyl 3-bromopropiolate 95+% | M38132 | 100mg | $11 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312-H315-H319-H331-H335 |
| Precautionary statements | P261-P280-P305+P351+P338-P311 |
Methyl-3-bromopropiolate price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM160166 | Methyl 3-bromopropiolate | 23680-40-2 | 1000mg | $150 | 2026-06-04 | Buy |
| Biosynth | FM160166 | Methyl 3-bromopropiolate | 23680-40-2 | 500mg | $150 | 2026-06-04 | Buy |
| Biosynth | FM160166 | Methyl 3-bromopropiolate | 23680-40-2 | 250mg | $150 | 2026-06-04 | Buy |
| Biosynth | FM160166 | Methyl 3-bromopropiolate | 23680-40-2 | 2000mg | $220 | 2026-06-04 | Buy |
| Synthonix | M38132 | Methyl 3-bromopropiolate 95+% | 23680-40-2 | 100mg | $11 | 2026-05-06 | Buy |
Methyl-3-bromopropiolate Chemical Properties,Uses,Production
Application
3-Bromopropynate methyl ester is a pharmaceutical intermediate obtained by brominating methyl propynate with NBS. Literature reports its potential use in preparing a class of compounds for cartilage repair.
Synthesis Reference(s)
Synthetic Communications, 22, p. 567, 1992 DOI: 10.1080/00397919208019255
Synthesis
922-67-8
23680-40-2
The general procedure for the synthesis of methyl 3-bromopropiolate from methyl propiolate: methyl propiolate (60 g, 713.6 mmol) was dissolved in acetone (2 L), followed by the sequential addition of N-bromosuccinimide (147.22 g, 827.13 mmol) and silver nitrate (12.12 g, 71.37 mmol). A slight exothermic phenomenon was observed during the reaction and the reaction temperature was increased from 21°C to 32°C. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the resulting gray suspension was evaporated by vacuum to remove the solvent, pentane (100 mL) was added and filtered through Celite, and the filter cake was washed with additional pentane. The process was repeated twice and all filtrates were combined and vacuum evaporated to give 113 g of methyl 3-bromopropiolate in 98% yield, which contained about 10% unreacted material. The product was characterized by 1H NMR (400 MHz, CDCl3) with a chemical shift δ of 3.78 (s, 3H).
References
[1] Patent: WO2015/166373, 2015, A1. Location in patent: Page/Page column 148
[2] Organic Syntheses, 1997, vol. 74, p. 212 - 212
[3] Synthetic Communications, 1992, vol. 22, # 4, p. 567 - 572
[4] Patent: US2003/236264, 2003, A1. Location in patent: Page 44
[5] Patent: US2003/236270, 2003, A1. Location in patent: Page 33
Methyl-3-bromopropiolate Preparation Products And Raw materials
Methyl-3-bromopropiolate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| Hong Kong Tiansheng New Material Trading Co., Ltd | +8617320695765 | zxx@hktiansheng.com | China | 973 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
View Lastest Price from Methyl-3-bromopropiolate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | Methyl-3-bromopropiolate
23680-40-2
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2022-02-25 | 2-Propynoic acid,3-bromo-, methyl ester
23680-40-2
|
$15.00 | 1Kg/Bag | 99% | 20 | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2020-01-13 | Methyl-3-bromopropiolate
23680-40-2
|
$1.00 | 1g | 98% | 100KG | Career Henan Chemical Co |
-
- Methyl-3-bromopropiolate
23680-40-2
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
-
- 2-Propynoic acid,3-bromo-, methyl ester
23680-40-2
- $15.00
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- Methyl-3-bromopropiolate
23680-40-2
- $1.00
- 98%
- Career Henan Chemical Co
