ChemicalBook >> CAS DataBase List >>[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo-
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo-
![[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- Structure](CAS/20210305/GIF/2869954-34-5.gif)
- CAS No.
- 2869954-34-5
- Chemical Name:
- [1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo-
- Synonyms
- RHO761;Werner syndrome RecQ helicase-IN-1;Werner syndrome RecQ helicase-IN-1 HRO761;Werner syndrome RecQ helicase-IN-1, 10 mM in DMSO;N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide;[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo-;N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)azine-1-yl)-7-oxy-[1,2,4]triazolebenzo[1,5-a]pyrimidine-4(7H)-yl)acetamide
- CBNumber:
- CB912471477
- Molecular Formula:
- C31H31ClF3N9O5
- Molecular Weight:
- 702.08
- MDL Number:
- MOL File:
- 2869954-34-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-13 13:05:00
| Product description | Number | Pack Size | Price |
| Werner Syndrome RecQ Helicase-IN-1 ≥98% | 41596 | 5mg | $109 |
| Werner Syndrome RecQ Helicase-IN-1 ≥98% | 41596 | 10mg | $174 |
| Werner Syndrome RecQ Helicase-IN-1 ≥98% | 41596 | 25mg | $382 |
| Werner Syndrome RecQ Helicase-IN-1 ≥98% | 41596 | 100mg | $981 |
| HRO761 99.52% | CS-0637948 | 5mg | $206 |
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- Properties
| Density | 1.58±0.1 g/cm3(Predicted) |
|---|---|
| solubility | DMSO: Slightly soluble: 0.1-1 mg/ml |
| pka | 5.87±0.45(Predicted) |
| form | Solid |
| color | White to light yellow |
| InChIKey | XKYVECRUZPCRQR-UHFFFAOYSA-N |
| SMILES | C12=NC(C3=CCOCC3)=NN1C(=O)C(N1CCN(C(C3C(O)=C(C)N=CN=3)=O)CC1)=C(CC)N2CC(NC1=CC=C(C(F)(F)F)C=C1Cl)=O |
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41596 | Werner Syndrome RecQ Helicase-IN-1 ≥98% | 2869954-34-5 | 5mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 41596 | Werner Syndrome RecQ Helicase-IN-1 ≥98% | 2869954-34-5 | 10mg | $174 | 2026-04-30 | Buy |
| Cayman Chemical | 41596 | Werner Syndrome RecQ Helicase-IN-1 ≥98% | 2869954-34-5 | 25mg | $382 | 2026-04-30 | Buy |
| Cayman Chemical | 41596 | Werner Syndrome RecQ Helicase-IN-1 ≥98% | 2869954-34-5 | 100mg | $981 | 2026-04-30 | Buy |
| ChemScene | CS-0637948 | HRO761 99.52% | 2869954-34-5 | 5mg | $206 | 2026-06-04 | Buy |
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- Chemical Properties,Uses,Production
Uses
HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research[1].
References
[1] Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060
[2] STEPHANE FERRETTI. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers[J]. Nature, 2024, 629 8011: 443-449. DOI: 10.1038/s41586-024-07350-y
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- Preparation Products And Raw materials
Raw materials
Preparation Products
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- Suppliers
Global( 52)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Soochow Chirally Material Science and Technology Co.,Ltd | +86-51266834346 +86-17751128648 | sales@krl-tech.com | China | 1050 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10002 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4590 | 58 |
| Changzhou Borl Biotechnology Co.,LTD | 13606124132;13656121842 | luyan0021@163.com | China | 261 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2826 | 55 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9416 | 55 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Lastest Price from [1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- manufacturers
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- Spectrum
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo-
Werner syndrome RecQ helicase-IN-1
N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide
Werner syndrome RecQ helicase-IN-1, 10 mM in DMSO
N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)azine-1-yl)-7-oxy-[1,2,4]triazolebenzo[1,5-a]pyrimidine-4(7H)-yl)acetamide
RHO761
Werner syndrome RecQ helicase-IN-1 HRO761
2869954-34-5
