DI-TERTBUTYLNITROPHENOL
- CAS No.
- 728-40-5
- Chemical Name:
- DI-TERTBUTYLNITROPHENOL
- Synonyms
- B-28589;BAY-28589;NSC 81682;ENT-25569;Bayer-28589;DI-TERTBUTYLNITROPHENOL;3,4-Di-tert-butyl-2-nitrophenol;4-Nitro-2,6-di-tert-butylphenol;2,6-Bis(1,1-dimethylethyl)-4-nitrophenol;4-Nitro-2,6-bis-(1,1-dimethylethyl)phenol
- CBNumber:
- CB91442055
- Molecular Formula:
- C14H21NO3
- Molecular Weight:
- 251.32
- MDL Number:
- MOL File:
- 728-40-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2,6-di(tert-butyl)-4-Nitrobenzenol AldrichCPR | CDS012535 | 50 mg | $197 |
| 2,6-Di-tert-butyl-4-nitrophenol | TRC-D493720-5G | 5g | $749 |
| 2,6-Di-tert-butyl-4-nitrophenol | TRC-D493720-500MG | 500mg | $192 |
| 2,6-Di-tert-butyl-4-nitrophenol | TRC-D493720-1G | 1g | $263 |
| 2,6-di(tert-butyl)-4-Nitrobenzenol | AAA72840 | 10g | $375 |
| More product size | |||
| Melting point | 154-156℃ |
|---|---|
| Boiling point | 307℃ |
| Density | 1.078 |
| refractive index | 1.5774 (estimate) |
| Flash point | 118℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.17±0.40(Predicted) |
| color | Light Yellow to Yellow |
| InChI | InChI=1S/C14H21NO3/c1-13(2,3)10-7-9(15(17)18)8-11(12(10)16)14(4,5)6/h7-8,16H,1-6H3 |
| InChIKey | FCGKUUOTWLWJHE-UHFFFAOYSA-N |
| SMILES | C1(O)=C(C(C)(C)C)C=C([N+]([O-])=O)C=C1C(C)(C)C |
| FDA UNII | R4V8VYQ7XL |
| EPA Substance Registry System | Phenol, 2,6-bis(1,1-dimethylethyl)-4-nitro- (728-40-5) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H319 |
| Precautionary statements | P264-P280-P301+P310-P305+P351+P338-P337+P313-P405 |
| RIDADR | 2811 |
| WGK Germany | WGK 3 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 |
DI-TERTBUTYLNITROPHENOL price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS012535 | 2,6-di(tert-butyl)-4-Nitrobenzenol AldrichCPR | 728-40-5 | 50 mg | $197 | 2026-04-30 | Buy |
| TRC | TRC-D493720-5G | 2,6-Di-tert-butyl-4-nitrophenol | 728-40-5 | 5g | $749 | 2026-06-03 | Buy |
| TRC | TRC-D493720-500MG | 2,6-Di-tert-butyl-4-nitrophenol | 728-40-5 | 500mg | $192 | 2026-06-03 | Buy |
| TRC | TRC-D493720-1G | 2,6-Di-tert-butyl-4-nitrophenol | 728-40-5 | 1g | $263 | 2026-06-03 | Buy |
| Biosynth | AAA72840 | 2,6-di(tert-butyl)-4-Nitrobenzenol | 728-40-5 | 10g | $375 | 2026-06-04 | Buy |
DI-TERTBUTYLNITROPHENOL Chemical Properties,Uses,Production
Uses
2,6-Di-tert-butyl-4-nitrophenol is a potentially powerful uncoupler of ATP-generating oxidative phosphorylation that has been reported to be a contaminant in submarines and indoor spaces, causing a number of objects to turn yellow (even human skin).
Synthesis
128-39-2
728-40-5
General procedure for the synthesis of 2,6-di-tert-butyl-4-nitrophenol from 2,6-di-tert-butylphenol: 2,6-di-tert-butylphenol (8 g, 39 mmol) was dissolved in 25 ml of cyclohexane at 10 °C. A mixed acid (5 ml) consisting of nitric acid and acetic acid mixed 1:1 by volume was slowly added dropwise to the reaction system while maintaining the reaction temperature at 10 °C. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 15 minutes. Upon completion of the reaction, the precipitate formed was collected by filtration and washed sequentially with water and pentane. The resulting crude product of 2,6-di-tert-butyl-4-nitrophenol (6.34 g, 65% yield) was dried in an oven and used in subsequent steps without further purification. The product was a light yellow powder with a melting point of 167-168 °C. 1H NMR (CDCl3, 100 MHz, δ): 1.48 (s, 18H, 2×t-Bu), 5.93 (s, 1H, OH), 8.13 (s, 2H, Ar-H).
References
[1] Journal of Chemical Research, 2011, vol. 35, # 2, p. 101 - 103
[2] Organic Letters, 2009, vol. 11, # 18, p. 4172 - 4175
[3] Patent: US6335445, 2002, B1. Location in patent: Page column 91
[4] Patent: US6727239, 2004, B1. Location in patent: Page column 19
[5] Journal of the Chemical Society. Perkin Transactions 2, 2002, # 6, p. 1112 - 1117
DI-TERTBUTYLNITROPHENOL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| Changzhou Helios Biomedical Science and Technology Co.,LTD. | +8618961213068 | gaoxue@czhelios.com | China | 512 | 58 |
| Suzhou Laing Biotechnology Co.,Ltd | +86-13004516015 +86-18149392822 | christina@laingbiotec.com | China | 777 | 58 |
View Lastest Price from DI-TERTBUTYLNITROPHENOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | DI-TERTBUTYLNITROPHENOL
728-40-5
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
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- DI-TERTBUTYLNITROPHENOL
728-40-5
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
