2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester
- CAS No.
- 710348-69-9
- Chemical Name:
- 2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester
- Synonyms
- 2-Oxo-2,3-dihydro-1H-benzoiMidazole-5-boronic acid;2-Hydroxybenzimidazole-5-boronic acid, pinacol ester;2-Oxo-2,3-dihydrobenzimidazole-5-boronic Acid Pinacol Ester;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydrob...;2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-benzo[d]imidazol-2-ol;2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester;5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one;5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydrobenzimidazol-2-one;5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2H-benziMidazol-2-one
- CBNumber:
- CB91486464
- Molecular Formula:
- C13H17BN2O3
- Molecular Weight:
- 260.1
- MDL Number:
- MFCD09260491
- MOL File:
- 710348-69-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester Aldrich | BML00181 | 1g | $506 |
| 2,3-Dihydro-2-oxo-1H-benzimidazole-5-boronic acid, pinacol ester 97% | OR3191 | 100mg | $21 |
| 2,3-Dihydro-2-oxo-1H-benzimidazole-5-boronic acid, pinacol ester 97% | OR3191 | 250mg | $33 |
| 2,3-Dihydro-2-oxo-1H-benzimidazole-5-boronic acid, pinacol ester 97% | OR3191 | 1g | $109 |
| 2,3-Dihydro-2-oxo-1H-benzimidazole-5-boronic acid, pinacol ester 97% | OR3191 | 5g | $531 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| form | solid |
| color | grey |
| InChI | 1S/C13H17BN2O3/c1-12(2)13(3,4)19-14(18-12)8-5-6-9-10(7-8)16-11(17)15-9/h5-7H,1-4H3,(H2,15,16,17) |
| InChIKey | LQVSXEXWXILGBH-UHFFFAOYSA-N |
| SMILES | B3(OC(C(O3)(C)C)(C)C)c1cc2[nH][c]([nH]c2cc1)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P271-P280 |
| target organs | Respiratory system |
| WGK Germany | 3 |
| HS Code | 2933998090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BML00181 | 2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester Aldrich | 710348-69-9 | 1g | $506 | 2026-04-30 | Buy |
| Apolloscientific | OR3191 | 2,3-Dihydro-2-oxo-1H-benzimidazole-5-boronic acid, pinacol ester 97% | 710348-69-9 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR3191 | 2,3-Dihydro-2-oxo-1H-benzimidazole-5-boronic acid, pinacol ester 97% | 710348-69-9 | 250mg | $33 | 2026-06-04 | Buy |
| Apolloscientific | OR3191 | 2,3-Dihydro-2-oxo-1H-benzimidazole-5-boronic acid, pinacol ester 97% | 710348-69-9 | 1g | $109 | 2026-06-04 | Buy |
| Apolloscientific | OR3191 | 2,3-Dihydro-2-oxo-1H-benzimidazole-5-boronic acid, pinacol ester 97% | 710348-69-9 | 5g | $531 | 2026-06-04 | Buy |
2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester Chemical Properties,Uses,Production
Synthesis
39513-26-3
73183-34-3
710348-69-9
5-Bromo-1,3-dihydrobenzimidazol-2-one (20.0 g, 93.9 mmol) was dissolved in anhydrous N,N-dimethylformamide (DMF, 150 mL) purged with argon. To this solution was sequentially added bis(pinacolato)diboron (28.6 g, 113 mmol), potassium acetate (KOAc, 27.6 g, 282 mmol), and a 1:1 complex of dichlorobis(triphenylphosphine)palladium(II) (PdCl2(DPPF), 7.67 g, 9.40 mmol) with dichloromethane (CH2Cl2). The reaction mixture was heated to 95 °C and kept overnight under mechanical stirring. After completion of the reaction, it was cooled to room temperature and diluted with brine (500 mL) and ethyl acetate (EtOAc, 750 mL). The mixture was filtered to remove the dark brown solid and the solid portion was washed well with ethyl acetate. The organic layer was separated, washed with water (3 x 500 mL), subsequently dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was washed with dichloromethane/hexane (1:1) to afford the target product 2-oxo-2,3-dihydro-1H-benzimidazole-5-boronic acid pinacol ester (10.9 g, 44% yield). Thin layer chromatography (TLC) Rf = 0.52 (silica gel plate, unfolding reagent: dichloromethane/methanol = 85:15); melting point 313-315 °C (decomposition); 1H NMR (300 MHz, DMSO-d6) δ 1.27 (s, 12H), 6.92 (d, J = 7.7 Hz, 1H), 7.17 (s, 1H), 7.28 (d, J = 7.7 Hz, 1H), 10.62 (s, 1H), 10.74 (s, 1H); APCI MS m/z 261 [C13H17BN2O3 + H]+; HPLC purity 98.3%, retention time (tR) = 18.3 min; Calculated values for elemental analysis (C13H17BN2O3): C, 57.07; H, 6.82; N. Measured values: C, 56.69; H, 6.44; N, 10.21. HPLC conditions: Waters Symmetry C18 column (4.6 mm × 250 mm); mobile phase: water/acetonitrile (95:5 to 0:100 gradient elution); flow rate 1.0 mL/min (25 min); detection wavelength 254 nm.
References
[1] Patent: WO2004/52847, 2004, A2. Location in patent: Page 298
[2] Patent: WO2016/176449, 2016, A1. Location in patent: Page/Page column 94; 95; 97
[3] Patent: WO2007/80382, 2007, A1. Location in patent: Page/Page column 133
2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester Preparation Products And Raw materials
2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Young Lively PharminBlock Co.,Ltd | +undefined18600731423 | jason_gao@yl-pharminblock.com | China | 1944 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 |
View Lastest Price from 2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-03-08 | 2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester
710348-69-9
|
$3.00 | 1KG | 96%-99% | 500kg | Career Henan Chemical Co |
-
- 2-Oxo-2,3-dihydro-1H-benzoimidazole-5-boronic acid, pinacol ester
710348-69-9
- $3.00
- 96%-99%
- Career Henan Chemical Co
