5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
- CAS No.
- 882500-21-2
- Chemical Name:
- 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
- Synonyms
- 101906;5-Bromo-6-(trifluoromethyl)pyridine;5-bromo-6-(trifluoromethyl)pyridin-2-amine;2-Pyridinamine,5-bromo-6-(trifluoromethyl)-;2-Amino-5-bromo-6-(trifluoromethyl)pyridine;6-Amino-3-bromo-2-(trifluoromethyl)pyridine;5-Bromo-6-trifluoromethyl-pyridin-2-ylamine;5-Bromo-6-trifluoromethyl-pyridin-2-ylamine ISO 9001：2015 REACH
- CBNumber:
- CB91559940
- Molecular Formula:
- C6H4BrF3N2
- Molecular Weight:
- 241.01
- MDL Number:
- MFCD11848010
- MOL File:
- 882500-21-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | PC201346 | 250mg | $21 |
| 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | PC201346 | 1g | $24 |
| 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | PC201346 | 5g | $56 |
| 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | PC201346 | 25g | $190 |
| 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | PC201346 | 100g | $611 |
| More product size | |||
| Boiling point | 218℃ |
|---|---|
| Density | 1.790 |
| Flash point | 86℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 1.04±0.10(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | InChI=1S/C6H4BrF3N2/c7-3-1-2-4(11)12-5(3)6(8,9)10/h1-2H,(H2,11,12) |
| InChIKey | DNDAEASRGBLZCN-UHFFFAOYSA-N |
| SMILES | C1(N)=NC(C(F)(F)F)=C(Br)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
5-Bromo-6-trifluoromethyl-pyridin-2-ylamine price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC201346 | 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | 882500-21-2 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC201346 | 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | 882500-21-2 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC201346 | 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | 882500-21-2 | 5g | $56 | 2026-06-04 | Buy |
| Apolloscientific | PC201346 | 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | 882500-21-2 | 25g | $190 | 2026-06-04 | Buy |
| Apolloscientific | PC201346 | 5-Bromo-6-trifluoromethylpyridin-2-ylamine 99% | 882500-21-2 | 100g | $611 | 2026-06-04 | Buy |
5-Bromo-6-trifluoromethyl-pyridin-2-ylamine Chemical Properties,Uses,Production
Uses
5-Bromo-6-trifluoromethyl-2-aminopyridine is a pyridine derivative that can be used as a pharmaceutical intermediate.
Synthesis
34486-24-3
882500-21-2
The general procedure for the synthesis of 5-bromo-6-(trifluoromethyl)-2-aminopyridine from 2-amino-6-(trifluoromethyl)pyridine was as follows: to a solution of 6-(trifluoromethyl)pyridin-2-amine (600 mg, 3.7 mmol) in methanol (10 mL) was added N-bromosuccinimide (NBS, 659 mg, 3.7 mmol) in batches at 0 °C. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 4:1) to afford 5-bromo-6-trifluoromethyl-2-aminopyridine (650 mg, 73.1% yield) as a white solid.The LC-MS analysis showed a retention time of 1.33 min and a molecular ion peak (MH+) of 241.
References
[1] Patent: WO2016/44792, 2016, A1. Location in patent: Page/Page column 173
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 527 - 531
[3] Patent: WO2017/1926, 2017, A2. Location in patent: Paragraph 00139
[4] Patent: CN105541792, 2016, A. Location in patent: Paragraph 0242; 0243; 0244
5-Bromo-6-trifluoromethyl-pyridin-2-ylamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23541 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9996 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9047 | 58 |
View Lastest Price from 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-06-25 | 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
882500-21-2
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-07-13 | 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
882500-21-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
882500-21-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
882500-21-2
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
882500-21-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
882500-21-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
