[CAS NO. 475-38-7]??Naphthazarin
PRODUCTS SPECIFICATIONS [475-38-7]
DESCRIPTION [475-38-7]
Overview
| MDL | MFCD00001685 |
|---|---|
| Molecular Weight | 190.15 |
| Molecular Formula | C10H6O4 |
| SMILES | O=C1C=CC(C2=C1C(O)=CC=C2O)=O |
1 Publications Citing Use of MCE
Summary
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects [1] [2] .
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 7.14 mg/mL ( 37.55 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.2590 mL | 26.2950 mL | 52.5901 mL |
| 5 mM | 1.0518 mL | 5.2590 mL | 10.5180 mL |
| 10 mM | 0.5259 mL | 2.6295 mL | 5.2590 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 0.71 mg/mL (3.73 mM); Suspended solution; Need ultrasonic
References
- [1] Seon Young Choi, et al. Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. J Neurosci Res. 2012 Sep;90(9):1842-9.
- [2] Omar Aljanadi, et al. Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):369-74.
Synonyms