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ChemicalBook >> CAS DataBase List >>Melanotan II

Melanotan II

CAS No.
121062-08-6
Chemical Name:
Melanotan II
Synonyms
Melanotan 2;Melanotan Il;MTII;MT-Ⅱ;MelanotanII Acetate(MT-2);MTIl;MT-Ⅱ;Melanotan ll;MT-II (Melanotan II);AC-NLE-CYCLO[(BETA-D)-HFRW-(EPSILON-K)]-NH2
CBNumber:
CB9213757
Molecular Formula:
C50H69N15O9
Molecular Weight:
1024.18
MDL Number:
MFCD01318793
MOL File:
121062-08-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
Melanotan II acetate salt ≥95% (HPLC) M8693 1mg $248
Anti-MTNR1B (AB2) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution SAB2900213 50μG $603
Ac-Nle-Cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 PMC-3683-PI 1mg $150
Ac-Nle-Cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 PMC-3683-PI 5mg $482.15
Melanotan II FA109114 10mg $454.3
More product size

Melanotan II Properties

Density 1.43
RTECS OL4225000
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility H2O: 5 mg/mL, soluble
form solid
pka 13.00±0.70(Predicted)
color white
Water Solubility Soluble to 0.70 mg/ml in water
Sequence Ac-{Nle}-Asp-His-{d-Phe}-Arg-Trp-Lys-NH2, (2→7)-lactam
InChIKey JDKLPDJLXHXHNV-MFVUMRCOSA-N
CAS DataBase Reference 121062-08-6(CAS DataBase Reference)
FDA UNII UPF5CJ93X7
UNSPSC Code 51111800
NACRES NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P302+P352-P362+P364
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
HS Code  3504009000
Storage Class 11 - Combustible Solids

Melanotan II price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M8693 Melanotan II acetate salt ≥95% (HPLC) 121062-08-6 1mg $248 2026-04-30 Buy
Sigma-Aldrich SAB2900213 Anti-MTNR1B (AB2) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 121062-08-6 50μG $603 2022-05-15 Buy
Biosynth PMC-3683-PI Ac-Nle-Cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 121062-08-6 1mg $150 2026-06-04 Buy
Biosynth PMC-3683-PI Ac-Nle-Cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 121062-08-6 5mg $482.15 2026-06-04 Buy
Biosynth FA109114 Melanotan II 121062-08-6 10mg $454.3 2026-06-04 Buy
Product number Packaging Price Buy
M8693 1mg $248 Buy
SAB2900213 50μG $603 Buy
PMC-3683-PI 1mg $150 Buy
PMC-3683-PI 5mg $482.15 Buy
FA109114 10mg $454.3 Buy

Melanotan II Chemical Properties,Uses,Production

Description

Melanotan II is a synthetic analogue of the melanocortin peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that occurs naturally. In usage, Melanotan II has been revealed to have aphrodisiac and melanogenesis (tanning) effects that have been subjected to clinical trials and preliminary studies. The compound is a cyclic lactam analogue of α-MSH that has an amino sequence named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2). Notably, no government drug regulatory agency across the world had approved for the use of any compound incorporating the Melanotan II peptide by 2010

Historical Development

Melanotan II was first developed at the University of Arizona. Various studies conducted at the institution confirmed that the best defence against skin cancer was melanin activated in the skin, a tan. The researchers assumed that an effective procedure to reduce the rates of skin cancer in individuals would be by inducing the body’s natural pigmentary system to produce a tan that would be protective before exposure to UV. Melanogenesis is a process by which the skin’s pigment cells (melanocytes) produce the hormone α-MSH naturally causes the skin's pigment (melanin).
After numerous clinical trials by administration of the endogenous hormone to the body, the scientists found that though it appeared to work, α-MSH had a very short half-life in the body to be practical as a therapeutic drug. Therefore, they opted to look for a more stable and potent alternative that would be more practical. Subsequently, after numerous trials, they developed Melanotan I and after that Melanotan II.

Uses

Malanotan II is used for tanning of the skin and producing of erections in men with erectile dysfunction when administered as a shot under the skin. Malanotan II is safe when used under strict medical supervision for treating erectile dysfunction. However, it may cause stomach cramps, tiredness, nausea, spontaneous erections of the penis, and darkened skin.

BENEFITS OF A MELANOTAN II

Darker tan with less exposure to UV radiation
Tanning without sunburn, even for fair-skinned individuals
Possible reduction in the risk of Melanoma (skin cancer)
Possible reduction in the incidence of sun-damaged skin
Possible reduction in body fat
No sunburn, n tan lines
No sunless tanning streaks or fake tan removal
Possible increase libido
During clinical trials for its use as a tanning agent, melanotan II was found to be a potent stimulator of male erections. It has also been shown to increase female sexual desire in patients with sexual arousal disorder).

SIDE EFFECTS

Short term side effects after administration include:
Facial flushing
Reduced appetite, nausea and vomiting
In males, spontaneous erections 1-5 hours after administration (priapism), associated with yawning and stretching complex
Long term, there is concern that melanotan II may increase the risk of:
Melanoma – a potentially serious form of skin cancer
Deepening of the color of moles, new moles and atypical melanocytic naevi
Melanonychia – brown to black discoloration of one or more nails
Suggested usage: daily for 1 - 2 weeks then one to two times weekly for maintenance.

Controversy

Melanotan II is widely sold online and in beauty salons as well as gyms as melanotan in their marketing. These products purport to contain the same chemical composition as afamelanotide. These products have been declared illegal and do not have the same chemical components as Melanotan II. As such, countries issues warnings against their use.

Dosage

Melanotan 2 has a half life of ~33 hours, this allows you to be very flexible with dosing. Recommended dosages start at 250mcg every day to help your body acclimatize to the peptide and minimize the side effects. You can continue with this dose indefinitely if you are intending to do a low dosage regimen.
If you want to dose higher, after 2-4 days, whenever you feel comfortable, up the dose to 500mcg. 500mcg is the most common dosage amount administed by users. You can increase the dose as far as about 1mg but any higher is generally not advised and the users dosing 1mg/dose normally weigh around the 100kg mark.

Uses

Melanotan II acetate salt has been used to study its inhibitory effects on feeding and energy expenditure in rats. It is a lab-made chemical that is similar to a hormone found in people. Melanotan II has been shown to have melanogenesis (tanning) and aphrodisiac effects on humans.

Biochem/physiol Actions

Melanotan II is a MC3-R/MC4-R melanocortin agonist. It is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.

Clinical Use

Melanotan II has been a new treatment for rosacea discussed in the various rosacea support groups on the internet.
Melanotan I and Melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (a-MSH) that tend to induce skin tanning. Melanotan II has the additional effect of increasing libido.
Melanotan II is an α-MSH analog which underwent clinical trials for the treatment of erectile dysfunction. Preliminary double-blind, placebo-controlled studies demonstrated the efficacy of melanotan in inducing penile erection in men with erectile dysfunction, although in a very restricted population.Unfortunately, there are no experimental data on the mode of action of melanotan II, as melanotan II is the first α-MSH agonist inducing penile erection when injected peripherally.
Illustration of the proerectile effect of melanotan II (MT-II) in humans. Placebo (A) or MT-II (B, 25 ug/kg and C, 133 ug/kg) was injected subcutaneously in patients and RigiScan recording was performed from 6 h. Apparent erections developed in 8 of 10 men treated with MT-II. (Reproduced with permission from Wessells H et al. Effect of an alphamelanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 2000; 56:641–646.)

Side effects

When given as a shot: Melanotan is POSSIBLY UNSAFE when given as a shot. It can causes nausea, stomachcramps, decreased appetite, flushing, tiredness, yawning, darkened skin, spontaneous erections of the penis, and other side effects. In some people, especially those with light skin, a change in the shape of moles, new moles, and skin cancer, have all occurred in people using melanotan.

storage

Store at -20°C

Background

Melanotan and Melanotan-II are both analogs of the peptide hormone alpha melanocyte stimulating hormone (a-MSH) that tend to induce skin tanning. Unlike Melanotan, Melanotan-II has the additional effect of increasing libido. Melanotan II has aphrodisiac properties.

References

[1] SOPHIA HATZIIEREMIA. A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice[J]. Rapid Communications in Mass Spectrometry, 2007. DOI:10.1002/rcm.3106.
[2] WEKWEJTPATRYK   KirykAnna  WojdaUrszula. Melanotan-II reverses memory impairment induced by a short-term HF diet.[J]. Biomedicine & Pharmacotherapy, 2023. DOI:10.1016/j.biopha.2023.115129.
[3] HJULER K F, LORENTZEN H F. Melanoma Associated with the Use of Melanotan-II[J]. Dermatology, 2013, 228: 34-36. DOI:10.1159/000356389.
[4] DORR R T, LINES R, LEVINE N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.[J]. Life sciences, 1996, 58 20: 1777-1784. DOI:10.1016/0024-3205(96)00160-9.

117499-53-3
121062-08-6
Synthesis of Melanotan II from L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-

Melanotan II Preparation Products And Raw materials

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Related Qustion

Ask a question
Q:How does Melanotan II work?Walter - Mar 31，2026
A:α-Melanocyte-stimulating-hormone (α-MSH) is produced in the pituitary gland of the brain and is naturally present in our bodies. It acts on specialised skin cells responsible for producing pigment. Melanotan II is a synthetic version of α-MSH, it hacks the body's regulation of pigment cells, tricking the body into tanning itself.

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Melanotan II pictures 2026-07-29 Melanotan II
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Melanotan II pictures 2026-07-29 Melanotan II
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Melanotan II pictures 2026-07-29 Melanotan II
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 $9.00 10VIAL 99.9% 10000 Guangzhou XinPeptide International Co.,Ltd
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Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) aMide Melanotan II, MTII, BreMelanotide aMide AC-NLE-CYCLO(-BETA-ASP-HIS-D-PHE-ARG-TRP-EPSILON-LYS-NH2) AC-NLE-CYCLO(-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2) ACETATE SALT AC-NLE4-C[ASP5, D-PHE7, LYS10]ALPHA-MSH (4-10)-NH2 AC-[NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10)-NH2 (AC-NLE4, ASP5, DPHE7, LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2 (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-10-(benzyl)-7-(3-guanidinopropyl)-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaketo-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-7-[3-(diaminomethylideneamino)propyl]-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-10-(phenylmethyl)-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-7-[3-[bis(azanyl)methylideneamino]propyl]-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-10-(phenylmethyl)-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 (AMide bond Asp5-Lys10) Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-a-MSH (4-10) aMide Melanotan II, MTII, BreMelanotide aMide Melanotan ② Malanotan II Acetate Melanotan II SynonyMs Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 melanotan,Melanotan II Anti-MTNR1B (C-terminal) antibody produced in goat melatonin receptor 1B melatonin receptor MEL1B Anti-MTNR1B (AB2) antibody produced in rabbit Anti-MTNR1B (AB1) antibody produced in rabbit mt2 melatonin receptor mt2 receptor Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) amide, Melanotan II [N-ACETYL-NLE4,ASP5,D-PHE7,LYS10]-ALPHA-MSH (4-10) AMIDE ASP5-LYS10, CYCLIC LACTAM Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2 Melanotan Ц MalanotanIi Mt-Ii(Melanotan) MelanotanAcetate Melanotan-II(MT-II) Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2 N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide (2->7)-lactam Melanotan Ⅱ Actate MelanotanⅡAcetate (Ac-Nle4,Asp5,D-Phe7,Lys10)-cyclo-a-MSH (4-10) amide Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2 Melanotan II acetate salt Muscarinic Toxin-2 from Dendroaspis angusticeps venom Ac-Nle4, Asp5, DPhe7, Lys10-Cyclo-a-MSH: 4-10 amide, MTII Melanotan-II Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys-NH2) AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM AC-NLE-C[+ASP-HIS-DPHE-ARG-TRP-LYS]-NH2 [ACETYL-NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MELANOCYTE STIMULATING HORMONE (4-10) AMIDE [ACETYL-NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10) AMIDE (ACETYL-NLE4,ASP5,D-PHE7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE ACETATE SALT MELANOTAN II M.W. 1024.19 C50H69N15O9 Melanotan II Acetate(MT-II) MT2/Melanotan-II Melanotan II acetate salt, ≥95% (HPLC) EGF Serum Epidermal Growth Factor AFGF Powder warehouse MT2 Melanotan II (MT-II) Acetate L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam Melanotan-II/MT2 MelanotanIIacetatesal
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