8-BROMO-2,4-DICHLOROQUINAZOLINE
- CAS No.
- 331647-05-3
- Chemical Name:
- 8-BROMO-2,4-DICHLOROQUINAZOLINE
- Synonyms
- 8-BROMO-2,4-DICHLOROQUINAZOLINE;2,4-DICHLORO-8-BROMOQUINAZOLINE;Quinazoline, 8-bromo-2,4-dichloro-;8-BROMO-2,4-DICHLOROQUINAZOLINE ISO 9001：2015 REACH
- CBNumber:
- CB92464540
- Molecular Formula:
- C8H3BrCl2N2
- Molecular Weight:
- 277.93
- MDL Number:
- MFCD09954891
- MOL File:
- 331647-05-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 8-Bromo-2,4-dichloroQuinazoline Asreported | 264360 | 250mg | $641 |
| 8-Bromo-2,4-dichloroQuinazoline Asreported | 264360 | 500mg | $948 |
| 8-Bromo-2,4-dichloroQuinazoline Asreported | 264360 | 1g | $1391 |
| 8-Bromo-2,4-dichloroQuinazoline Asreported | 264360 | 2g | $2063 |
| 8-Bromo-2,4-dichloroQuinazoline Asreported | 264360 | 5g | $3097 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| HazardClass | IRRITANT |
| HS Code | 2933599590 |
8-BROMO-2,4-DICHLOROQUINAZOLINE price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 264360 | 8-Bromo-2,4-dichloroQuinazoline Asreported | 331647-05-3 | 250mg | $641 | 2026-06-03 | Buy |
| Usbiological | 264360 | 8-Bromo-2,4-dichloroQuinazoline Asreported | 331647-05-3 | 500mg | $948 | 2026-06-03 | Buy |
| Usbiological | 264360 | 8-Bromo-2,4-dichloroQuinazoline Asreported | 331647-05-3 | 1g | $1391 | 2026-06-03 | Buy |
| Usbiological | 264360 | 8-Bromo-2,4-dichloroQuinazoline Asreported | 331647-05-3 | 2g | $2063 | 2026-06-03 | Buy |
| Usbiological | 264360 | 8-Bromo-2,4-dichloroQuinazoline Asreported | 331647-05-3 | 5g | $3097 | 2026-06-03 | Buy |
8-BROMO-2,4-DICHLOROQUINAZOLINE Chemical Properties,Uses,Production
Application
8-Bromo-2,4-Dichloroquinazoline is a quinazoline derivative, which is mainly used as an intermediate in pharmaceutical and chemical synthesis.
Synthesis
331646-99-2
331647-05-3
8-Bromoquinazoline-2,4(1H,3H)-dione (12.1 g, 50 mmol, 1 eq.) was used as starting material, which was dissolved in phosphorous trichloride (POCl3, 130 mL), followed by the addition of N,N-dimethylformamide (DMF, 0.5 mL) as catalyst. The reaction mixture was stirred at 130 °C for 12 h. After completion of the reaction, the reaction was cooled to room temperature. The reaction mixture was concentrated by rotary evaporator. The concentrated residue was dissolved in ethyl acetate (EA, 100 mL) and quenched by slowly pouring into ice water under vigorous stirring. The organic phase was separated, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated again. Finally, the target product 8-bromo-2,4-dichloroquinazoline was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 10:1, v/v) as a yellow solid (9.1 g, 60% yield).
References
[1] Organic Letters, 2011, vol. 13, # 4, p. 676 - 679
[2] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 9, p. 941 - 946
[3] Patent: WO2015/27222, 2015, A2. Location in patent: Paragraph 0214
[4] Patent: WO2016/133935, 2016, A1. Location in patent: Paragraph 0287
8-BROMO-2,4-DICHLOROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8886 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
View Lastest Price from 8-BROMO-2,4-DICHLOROQUINAZOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 8-BROMO-2,4-DICHLOROQUINAZOLINE
331647-05-3
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- 8-BROMO-2,4-DICHLOROQUINAZOLINE
331647-05-3
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
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