3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-
- CAS No.
- 942437-37-8
- Chemical Name:
- 3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-
- Synonyms
- AZD-7325;AZD-7325 ，S0164;AZD-7325 (AZD7325);AZD7325, 10 mM in DMSO;3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl-;modulator,effect,inhibit,Cytochrome P450,Dravet,syndrome,Inhibitor,γ-Aminobutyric acid Receptor,CYPs,sedative,AZD7325,PAM,CYP1A2,Gamma-aminobutyric acid Receptor,anxiety,AZD 7325,GABA Receptor
- CBNumber:
- CB92563380
- Molecular Formula:
- C19H19FN4O2
- Molecular Weight:
- 354.38
- MDL Number:
- MFCD21337369
- MOL File:
- 942437-37-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| AZD 7325 ≥98% | 36449 | 1mg | $32 |
| AZD 7325 ≥98% | 36449 | 5mg | $148 |
| AZD 7325 ≥98% | 36449 | 10mg | $234 |
| AZD7325 99.95% | CS-0034076 | 5mg | $87 |
| AZD7325 99.95% | CS-0034076 | 10mg | $130 |
| More product size | |||
| solubility | DMSO: soluble |
|---|---|
| form | A solid |
| color | White to off-white |
| FDA UNII | KNM216XOUH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 36449 | AZD 7325 ≥98% | 942437-37-8 | 1mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 36449 | AZD 7325 ≥98% | 942437-37-8 | 5mg | $148 | 2026-04-30 | Buy |
| Cayman Chemical | 36449 | AZD 7325 ≥98% | 942437-37-8 | 10mg | $234 | 2026-04-30 | Buy |
| ChemScene | CS-0034076 | AZD7325 99.95% | 942437-37-8 | 5mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-0034076 | AZD7325 99.95% | 942437-37-8 | 10mg | $130 | 2026-06-04 | Buy |
3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl- Chemical Properties,Uses,Production
Uses
AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (Ki=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1and Aα5receptor subtypes[1][4]. AZD7325 is a moderateCYP1A2and a potentCYP3A4inducer in vitro[2]. AZD7325 has the potential for the investigation of anxiety and dravet syndrome[3]. PAM: positive allosteric modulator.
in vivo
AZD7325 (oral administration; 10, 17.8 or 31.6 mg/kg; 30 minutes before the induction of hyperthermia) attenuates hyperthermia-induced seizures, shows median thresholds in the treatment groups of 42.8°C for 10 mg/kg, 43.3°C for 17.8 mg/kg, and 43.4°C for 31.6 mg/kg compares to 42.2°C in vehicle group[3].
| Animal Model: | Male and female P18 - P20 F1.Scn1a+/- mice[3] |
| Dosage: | 10, 17.8 or 31.6 mg/kg |
| Administration: | Oral administration; 30 minutes before the induction of hyperthermia |
| Result: | Attenuated hyperthermia-induced seizures in F1.Scn1a+/- mice with no sedative effect. |
IC 50
CYP1A2; CYP3A4
References
[1] Chen X, et al. The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males.Br J Clin Pharmacol. 2014 Dec;78(6):1298-314. DOI:10.1111/bcp.12413
[2] Zhou D, et al. A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison.Br J Clin Pharmacol.2012Jul;74(1):98-108. DOI:10.1111/j.1365-2125.2011.04155.x
[3] Nomura T, et al. Potentiating α2subunit containing perisomatic GABAAreceptors protects against seizures in a mouse model of Dravet syndrome.J Physiol.2019 Aug;597(16):4293-4307. DOI:10.1113/JP277651
[4] AZD7325,Mechanism of action: Gamma-aminobutyric acid receptor A alpha 2 & 3 (GABAAα2,3) positive modulator
3-CinnolinecarboxaMide, 4-aMino-8-(2-fluoro-6-Methoxyphenyl)-N-propyl- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9945 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 410 | 57 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4848 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
